Light and electron microscopical observations of the effects of high-density lipoprotein on growth of Plasmodium falciparum in vitro
Keyword(s):
Human serum high-density lipoprotein (HDL) is necessary and sufficient for the short-term maintenance of Plasmodium falciparum in in vitro culture. However, at high concentrations it is toxic to the parasite. A heat-labile component is apparently responsible for the stage-specific toxicity to parasites within infected erythrocytes 12–42 h after invasion, i.e. during trophozoite maturation. The effects of HDL on parasite metabolism (as determined by nucleic acid synthesis) are evident at about 30 h after invasion. Parasites treated with HDL show gross abnormalities by light and electron microscopy.
2004 ◽
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1978 ◽
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pp. 8034-8041
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1994 ◽
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pp. 11572-11577
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2016 ◽
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pp. 525-531
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pp. 2405-2417
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1980 ◽
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pp. 352-355
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