XVI.—On the Alkaloids contained in the Wood of the Bebeeru or Greenheart Tree (Nectandra Rodiœi, Schomb.)

In a paper read before the Royal Society of Edinburgh in April 1843, Dr Maclagan described the general properties of the alkaloid, whose presence had been indicated in the bark of the bebeeru or greenheart tree, by Dr Rodie of Demerara, and described the mode of preparation of its sulphate for medicinal use. The fact that bebeerine appeared to possess marked antiperiodic properties, rendered its careful chemical study desirable, and accordingly the alkaloid, purified as far as possible, was subjected to analysis by Drs Maclagan and Tilley. It resulted from this research that bebeerine is an uncrystallisable base, very soluble in alcohol, less so in ether, and very sparingly so in water. It forms with acids salts which are all uncrystallisable. With perchloride of gold, mercury, copper, and platinum, it gives precipitates which are soluble to a certain extent in water and alcohol, but which are deposited in a non-crystalline form when the solution cools. To this base the author assigned the formula C35H20N2O6(C = 6). Von Planta subsequently attempts to purify further the alkaloid, and assigned to it the formula C36H21O6N(C = 6) or C18H21O3N(C = 12.)

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II. On the frequent occurrence of phosphate of lime, in the crystalline form, in human urine, and on its pathological importance

Proceedings of the Royal Society of London ◽

10.1098/rspl.1859.0055 ◽

1860 ◽

Vol 10 ◽

pp. 281-288 ◽

Cited By ~ 4

Keyword(s):

Human Urine ◽

Royal Society ◽

Crystalline State ◽

Crystalline Form ◽

Frequent Occurrence ◽

The Other ◽

Triple Phosphate ◽

Frequent Presence ◽

At Home

In 1854 I submitted to the Royal Society a paper “On the frequent occurrence of Indigo in Human Urine.” This communication, which was published in the ‘Philosophical Transactions,’ attracted considerable attention both at home and abroad. The singular fact of the frequent presence of indigo in the urine, first announced by me, has since been amply confirmed by a variety of observers. I have now to place before the Society some investigations in relation to the not uncommon occurrence in human urine of phosphate of lime , as a deposit , in a well-marked crystalline form. When the earthy phosphates are treated of by writers, in connexion with the urine, they are usually described collectively, and it is seldom that each kind of phosphate is particularized, and yet there are several which may occur either separately or together. The phosphate of ammonia and magnesia, or triple phosphate, is indeed often specified, but rarely is phosphate of lime separately mentioned, and phosphate of magnesia scarcely ever; and yet phosphate of lime is very frequently present as a deposit in urine, much more so, indeed, according to my experience, than the triple phosphate, excluding those cases of the occurrence of that ammoniacal phosphate, arising from the decomposition of the urea of the urine subsequent to its escape from the kidneys. Even in those few cases in which phosphate of lime is specially mentioned, it is described usually as mixed up with the other phosphates, and always as occurring in the amorphous or granular , and never in the crystalline state; further, no peculiar importance is attached to it, as contrasted with the magnesian phosphate.

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XXV. An account of experiments on the influence of colloids upon crystalline form, and on movements observed in mixtures of colloids with crystalloids

Proceedings of the Royal Society of London ◽

10.1098/rspl.1879.0045 ◽

1879 ◽

Vol 29 (196-199) ◽

pp. 238-246 ◽

Cited By ~ 1

Keyword(s):

Royal Society ◽

Crystalline Form ◽

Alcoholic Extract ◽

Microscope Slide ◽

Thin Glass

In the “Proceedings of the Royal Society” for 1866, Dr. Montgomery has recorded some very remarkable observations made by him on the behaviour of “myelin” when brought into contact with water. “Myelin” being a term of various applications, it is necessary to state that the substance indicated in Dr. Montgomery’s statement is an alcoholic extract of yolk of egg. A small quantity being placed on a microscope-slide, and covered with thin glass, is brought under observation by a tolerably high object-glass.

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THE OCCURRENCE IN THE RABBIT OF AN ACUTE PHASE PROTEIN ANALOGOUS TO HUMAN C-REACTIVE PROTEIN

Journal of Experimental Medicine ◽

10.1084/jem.93.1.25 ◽

1951 ◽

Vol 93 (1) ◽

pp. 25-36 ◽

Cited By ~ 66

Author(s):

H. C. Anderson ◽

Maclyn McCarty

Keyword(s):

Acute Phase ◽

Special Form ◽

Acute Phase Protein ◽

Crystalline Form ◽

Rabbit Serum ◽

Normal Rabbit Serum ◽

C Reactive Protein ◽

Reactive Protein ◽

General Properties ◽

Phase Protein

The occurrence in the rabbit of an acute phase protein analogous to human C-reactive protein has been confirmed. The acute phase protein of the rabbit reacts with a special form of the pneumococcal somatic polysaccharide, designated Cx polysaccharide, in the same manner that the human C-reactive protein reacts with the classical C polysaccharide. The method of preparation and some of the properties of the Cx polysaccharide are described. The rabbit Cx-reactive protein has been shown to be remarkably similar to human C-reactive protein in its general properties and in the conditions which govern its appearance in the blood. It has been obtained in crystalline form, and appears to be antigenically distinct from the proteins of normal rabbit serum.

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