A glass appliqué in the shape a lion's head mask is an example of applied decoration found on late Roman glasses, which may have actually seen extended use as a keepsake or amulet, long after the vessel itself, presumably a globular or conical handled jug or bulbous flagon, had been broken. The medallion in high relief was found during Polish excavations on Kom el-Dikka in 2007, in a cut from the early Islamic period containing fill of mixed date, from late Roman to early Islamic. The paper considers parallels for the piece, both published and unpublished, from excavations in Egypt as well as museum collections worldwide. All are considered to be made in Egyptian workshops and representing traditional “Egyptian” themes, although the idea of decorating glass vessels with applied medallions was hardly a novel idea in the late Roman period and was a continuation of a tradition from Imperial times, but with a different range of motifs. Glass masks of this kind appeared also on other vessels, like glass cinerary urns, for example, and continued to be applied as decoration on late Sassanian and early Islamic products.