scholarly journals Invasive pneumococcal and meningococcal disease: association with influenza virus and respiratory syncytial virus activity?

2008 ◽  
Vol 136 (11) ◽  
pp. 1448-1454 ◽  
Author(s):  
A. G. S. C. JANSEN ◽  
E. A. M. SANDERS ◽  
A. VAN DER ENDE ◽  
A. M. VAN LOON ◽  
A. W. HOES ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Respiratory Syncytial Virus ◽  
Meningococcal Disease ◽  
Invasive Disease ◽  
Population Based ◽  
Older Children ◽  
Virus Activity ◽  
Syncytial Virus ◽  
Pneumococcal Bacteraemia ◽  
Rate Ratios

SUMMARYFew studies have examined the relationship between viral activity and bacterial invasive disease, considering both influenza virus and respiratory syncytial virus (RSV). This study aimed to assess the potential relationship between invasive pneumococcal disease (IPD), meningococcal disease (MD), and influenza virus and RSV activity in The Netherlands. Correlations were determined between population-based data on IPD and MD during 1997–2003 and influenza virus and RSV surveillance data. Incidence rate ratios of disease during periods of high influenza virus and RSV activity over the peri-seasonal and summer baseline periods were calculated. The analyses comprised 7266 and 3072 cases of IPD and MD. When data from all seasons were included, the occurrence of pneumococcal bacteraemia and MD correlated significantly with influenza virus and RSV activity both in children and adults. Periods of increased influenza virus and RSV activity showed higher rates of pneumococcal bacteraemia in older children and adults than the peri-season period. Rates of MD in children were also higher during periods of increased influenza virus activity; the same appeared true for MD in older children during periods of increased RSV activity. Although no causal relationship may be inferred from these data, they support a role for influenza virus and RSV in the pathogenesis of IPD and MD.

scholarly journals Association of Age at First Severe Respiratory Syncytial Virus Disease With Subsequent Risk of Severe Asthma: A Population-Based Cohort Study

2018 ◽  
Vol 220 (4) ◽  
pp. 550-556 ◽  
Author(s):  
Nusrat Homaira ◽  
Nancy Briggs ◽  
Ju-Lee Oei ◽  
Lisa Hilder ◽  
Barbara Bajuk ◽  
...  
Keyword(s):  
Cohort Study ◽  
Respiratory Syncytial Virus ◽  
Virus Disease ◽  
Population Based ◽  
Incidence Rates ◽  
Severe Respiratory Syncytial Virus ◽  
Respiratory Syncytial Virus Disease ◽  
Syncytial Virus ◽  
Rate Ratios ◽  
Subsequent Risk

Abstract Objective In a population-based cohort study, we determined the association between the age at first severe respiratory syncytial virus (RSV) disease and subsequent asthma. Methods Incidence rates and rate ratios of the first asthma-associated hospitalization after 2 years of age in children hospitalized for RSV disease at <3 months, 3 to <6 months, 6 to <12 months, and 12–24 months of age were calculated. Results The incidence of asthma-associated hospitalization per 1000 child-years among children hospitalized for RSV disease at <3 months of age was 0.5 (95% confidence interval [CI], .2–.7); at 3 to <6 months of age, 0.9 (95% CI,.5–1.3); at 6 to <12 months of age, 2.0 (95% CI, 1.4–2.7); and at 12–24 months of age, 1.7 (95% CI, 1.0–2.5). The rate ratio of hospitalization for asthma was 2–7-fold greater among children hospitalized for RSV disease at ages ≥6 months than that among those hospitalized for RSV disease at ages 0 to <6 months. Conclusions Although the burden of RSV disease is highest in children aged <6 months, the burden of subsequent asthma is higher in children who develop RSV disease at ages ≥6 months.

scholarly journals Characterizing the risk of respiratory syncytial virus in infants with older siblings: a population-based birth cohort study

2016 ◽  
Vol 145 (2) ◽  
pp. 266-271 ◽  
Author(s):  
P. JACOBY ◽  
K. GLASS ◽  
H. C. MOORE
Keyword(s):  
Respiratory Syncytial Virus ◽  
Birth Cohort ◽  
Vaccination Strategy ◽  
Population Based ◽  
Birth Cohort Study ◽  
Older Children ◽  
Rsv Infection ◽  
Maximum Protection ◽  
Syncytial Virus ◽  
Older Siblings

SUMMARYFrom a population-based birth cohort of 245 249 children born in Western Australia during 1996–2005, we used linkage of laboratory and birth record datasets to obtain data including all respiratory syncytial virus (RSV) detections during infancy from a subcohort of 87 981 singleton children born in the Perth metropolitan area from 2000 to 2004. Using log binomial regression, we found that the risk of infant RSV detection increases with the number of older siblings, with those having ⩾3 older siblings experiencing almost three times the risk (relative risk 2·83, 95% confidence interval 2·46–3·26) of firstborn children. We estimate that 45% of the RSV detections in our subcohort were attributable to infection from an older sibling. The sibling effect was significantly higher for those infants who were younger during the season of peak risk (winter) than those who were older. Although older siblings were present in our cohort, they had very few RSV detections which could be temporally linked to an infant's infection. We conclude that RSV infection in older children leads to less severe symptoms but is nevertheless an important source of infant infection. Our results lend support to a vaccination strategy which includes family members in order to provide maximum protection for newborn babies.

Compounds with anti-respiratory syncytial virus activity from endophytic fungus Pestalotiopsis thea

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
PF Uzor ◽  
DC Odimegwu ◽  
W Ebrahim ◽  
PO Osadebe ◽  
NJ Nwodo ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Endophytic Fungus ◽  
Virus Activity ◽  
Syncytial Virus

scholarly journals Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 234
Author(s):  
Sarah Al-Beltagi ◽  
Cristian Alexandru Preda ◽  
Leah V. Goulding ◽  
Joe James ◽  
Juan Pu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Respiratory Syncytial Virus ◽  
Influenza A Virus ◽  
Broad Spectrum ◽  
Influenza A ◽  
Respiratory Viruses ◽  
Influenza Viruses ◽  
Virus Challenge ◽  
2009 H1n1 ◽  
Syncytial Virus

The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to include antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass vaccination, the modest number of antivirals in use or development for any disease bears testament to the challenges of antiviral development. We recently showed that non-cytotoxic levels of thapsigargin (TG), an inhibitor of the sarcoplasmic/endoplasmic reticulum (ER) Ca2+ ATPase pump, induces a potent host innate immune antiviral response that blocks influenza A virus replication. Here we show that TG is also highly effective in blocking the replication of respiratory syncytial virus (RSV), common cold coronavirus OC43, SARS-CoV-2 and influenza A virus in immortalized or primary human cells. TG’s antiviral performance was significantly better than remdesivir and ribavirin in their respective inhibition of OC43 and RSV. Notably, TG was just as inhibitory to coronaviruses (OC43 and SARS-CoV-2) and influenza viruses (USSR H1N1 and pdm 2009 H1N1) in separate infections as in co-infections. Post-infection oral gavage of acid-stable TG protected mice against a lethal influenza virus challenge. Together with its ability to inhibit the different viruses before or during active infection, and with an antiviral duration of at least 48 h post-TG exposure, we propose that TG (or its derivatives) is a promising broad-spectrum inhibitor against SARS-CoV-2, OC43, RSV and influenza virus.

scholarly journals Reduced activation and proliferation of human lymphocytes exposed to respiratory syncytial virus compared to cells exposed to influenza virus

2017 ◽  
Vol 90 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Elisa H. Fleming ◽  
Eliana E. Ochoa ◽  
Joan E. Nichols ◽  
M. Kerry O'Banion ◽  
Alan R. Salkind ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Respiratory Syncytial Virus ◽  
Human Lymphocytes ◽  
Syncytial Virus
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