Identifying Vulnerability Markers in Prodromal Patients: A Step in the Right Direction for Schizophrenia Prevention

CNS Spectrums ◽  
2004 ◽  
Vol 9 (8) ◽  
pp. 595-602 ◽  
Author(s):  
Lucy Knowles ◽  
Tonmoy Sharma

ABSTRACTResearch has shown that many of the long-term deficits that are observable in schizophrenia populations are present prior to the emergence of psychotic symptoms. Recent research suggests schizophrenia has a “prodromal” period, whereby significant changes from premorbid functioning can be observed. Accurate classification of this period could have far-reaching implications for schizophrenia prevention. This article aims to provide an indepth evaluation of the perceived benefits of vulnerability marker research in this unique phase. It is hoped that identification of such markers may improve the predictive potency of prodromal criteria, and perhaps pave the way for future screening and primary prevention strategies.

Author(s):  
Mats Alvesson

‘Be something great’ and ‘fast track to top jobs’ were two headlines in advertisements for education that caught my eye some time ago. The specific message was that a specific school was offering a route to success and a brilliant career. In other words, education paves the way for success in life. With the passing of time, this has become a well-established truth. There are no other options—unless you have exceptional talents in the arts, sports, or the entertainment context. Fantasies and hopes for an outstanding career are encouraged on a broad front. The higher education sector has developed rapidly, even exploded, in recent decades and so have promises of a fantastic career resulting from a degree of the right kind and at the right place. In one UK university, the business school building is plastered with large posters claiming that ‘We create world-class minds’. And a Swedish university, located in a remote part of the country and with difficulties in recruiting faculty members and students, advertises heavily, claiming ‘research and education in world class’. If an institution is not ‘world class’ it is often described in terms of ‘excellence’. At my own university a few years ago, I saw a poster headed ‘Do you want to be President or Group CEO?’ for a course in commercial law specially designed for people who expect to reach the top in the near future. Since the target group consists of students, and most of them will probably have to bide their time for a decade or two before they can put ‘President’ or ‘Group CEO’ on their business cards, we may conclude that the department in question has realized the value of a long-term approach, and is assuming that many students have a high estimation of their potential. Perhaps education institutions support such more or less realistic self-images and career aspirations. If the department in question succeeds in recruiting a large number of students, it is perhaps primarily the less realistic self-images that will be reinforced. At a more collective level, education is now also considered to pave the way for national greatness.


1995 ◽  
Vol 113 (4) ◽  
pp. 935-940 ◽  
Author(s):  
Edward Esteves ◽  
Jaques Pinus ◽  
Renato Frota de Albuquerque Maranhão ◽  
Simone de Campos Vieira Abib ◽  
José Pinus

Crossed testicular ectopia (CTE) is a rare anomaly, characterized by migration of one testis towards the opposite inguinal canal. Presented here is a case of crossed ectopia of the right testis, treated by extraperitoneal transposition of the gonad and right orchiopexy. Embriology and surgical findings suggest that CTE is a common consequence of many unclear ethiologic factors, specially mechanical ones, and can be associated with Muller duct persistence. Review of literature suggests a classification of CTE into 3 types: I - associated with inguinal hernia alone; II - associated with persistent mullerian remnants; III - associated with other anomalies without mullerian remnants. Treatment includes transeptal orchiopexy or extraperitoneal transposition of the testis, research for mullerian remnants and other anomalies, and long term postoperative follow-up, due to the risk of becoming malignant.


2008 ◽  
Author(s):  
Martin Fenner

Results of clinical trials can sometimes not only change our understanding of the condition studied, but may also affect the way we practice medicine. The Justification for the Use of Statins in Primary Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) ...


2017 ◽  
Vol 22 (1) ◽  
pp. 85-106 ◽  
Author(s):  
Feng (Kevin) Jiang

Abstract Stance and voice are two crucial elements of social interactions in academic writing. However, their conceptual constructs are elusive and their linguistic realisation is not fully explored. A relatively overlooked feature is the “noun + that” structure, where a stance head noun takes a nominal complement clause (as advantage that in Flow cytometry offers the advantage that long term is available). This construction allows a writer to express authorial stance towards complement content and attribute a voice to that stance through pre-modification. This paper examines this construction in a corpus of 60 journal articles across six disciplines extracted from the BNC corpus. Developing an expressive classification of stance nouns and the possible voice categorisation, this study shows that the structure is not only widely used to project stance and voice, but that it displays considerable variation in the way that it is used to build knowledge across different disciplines.


2005 ◽  
Vol 30 (4) ◽  
pp. 1-10 ◽  
Author(s):  
J J Irani ◽  
Subir Raha ◽  
Suresh Prabhu

The fundamental concern of corporate governance is to ensure that the firm's directors and managers act ethically in the interests of the firm and its shareholders and that the managers are held accountable to capital providers for the use of assets. Corporate governance issues are in general receiving greater attention as a result of the increasing recognition that a firm's corporate governance affects both its economic performance and its ability to access long-term, low investment capital. However, business schools are sometimes blamed for having neglected corporate governance. We present here a conceptualization of governance from three different perspectives. J J Irani strongly feels that values are coming back into demand once again. Responding to the apprehensions of critics about playing the game of business according to rules, he comments that being ethical does not mean losing on profits. According to him, it is, in fact, most important to make profits and to generate wealth because only then can one have the resources to do good for the community. What is important is to note that ethics cannot be imposed by law. It has to come through a change of mindset. In Subir Raha's opinion, while business has always been conducted for profit, the perception about profit has changed. It is now interpreted as creating value, creating wealth. Managers are required to create wealth ethically with concern not only for the company but also for the community. Corporate social responsibility is the way corporates interact, the way they get involved with people outside. The crucial issue in management is confronting the decisions — good or bad. Corporate governance is about making the right judgment in a given situation even if it involves risks. Suresh Prabhu attributes all the problems in the country to the deteriorating standards of governance. Governance, in fact, is what we have created — the new functionaries with different responsibilities. If they deliver, governance would be of high order. Unfortunately, however, they do not deliver as the responsibilities and functions have not been codified. Reforming governance would mean overhauling the entire system. And, once public governance gets reformed, corporate governance would automatically improve. Following are the highlights emerging from the discussion: We need a change in our mindset which will allow us to use the superiority of our intellect to the advantage of corporate India. Training could help in mindset change. When confronted with the options of doing right or doing wrong, the managers need to test their judgment on their learning or value system in terms of corporate governance by doing the right thing that their training, knowledge, skill, judgment, and conscience tell them to do. The issue is the ability to make a judgment in a given situation and a given time and to confront the question: “Am I doing the right thing for my stakeholders?” If governance has to ultimately be reformed, the whole country has to change. We must go to the basics of the issue and start solving the problems.


2001 ◽  
Vol 12 (1) ◽  
pp. 23-39 ◽  
Author(s):  
MS Robson

Caesarean section rates in the United Kingdom continue to be a topic of importance in both the medical and lay press. In previous years most of the discussion has been about what the correct caesarean section rate should be. More recently the debate has focused on whether a woman has the right to choose to have her baby delivered by caesarean section in the absence of a medical indication. This has medical implications, in terms of short and long term complications for the woman, but also carries a financial burden that the National Health Service can ill afford.


2000 ◽  
Vol 5 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Ronny Swain

The paper describes the development of the 1998 revision of the Psychological Society of Ireland's Code of Professional Ethics. The Code incorporates the European Meta-Code of Ethics and an ethical decision-making procedure borrowed from the Canadian Psychological Association. An example using the procedure is presented. To aid decision making, a classification of different kinds of stakeholder (i.e., interested party) affected by ethical decisions is offered. The author contends (1) that psychologists should assert the right, which is an important aspect of professional autonomy, to make discretionary judgments, (2) that to be justified in doing so they need to educate themselves in sound and deliberative judgment, and (3) that the process is facilitated by a code such as the Irish one, which emphasizes ethical awareness and decision making. The need for awareness and judgment is underlined by the variability in the ethical codes of different organizations and different European states: in such a context, codes should be used as broad yardsticks, rather than precise templates.


Author(s):  
Linda MEIJER-WASSENAAR ◽  
Diny VAN EST

How can a supreme audit institution (SAI) use design thinking in auditing? SAIs audit the way taxpayers’ money is collected and spent. Adding design thinking to their activities is not to be taken lightly. SAIs independently check whether public organizations have done the right things in the right way, but the organizations might not be willing to act upon a SAI’s recommendations. Can you imagine the role of design in audits? In this paper we share our experiences of some design approaches in the work of one SAI: the Netherlands Court of Audit (NCA). Design thinking needs to be adapted (Dorst, 2015a) before it can be used by SAIs such as the NCA in order to reflect their independent, autonomous status. To dive deeper into design thinking, Buchanan’s design framework (2015) and different ways of reasoning (Dorst, 2015b) are used to explore how design thinking can be adapted for audits.


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