Neuropsychological asymmetry in Alzheimer's disease: Verbal versus visuoconstructional deficits across stages of dementia

1997 ◽  
Vol 3 (5) ◽  
pp. 420-427 ◽  
Author(s):  
DANIEL STRITE ◽  
PAUL J. MASSMAN ◽  
NORMA COOKE ◽  
RACHELLE S. DOODY
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Factor Analysis ◽  
Principal Component ◽  
Neuropsychological Deficits ◽  
Principal Component Factor Analysis ◽  
Factor Scores ◽  
Lateral Asymmetry ◽  
Mild Dementia ◽  
Component Factor

The incidence of clinically apparent asymmetric profiles of neuropsychological deficits in Alzheimer's disease (AD) patients similar to those reported in the PET literature is currently unclear. This study investigated lateral neuropsychological asymmetry using principal component factor analysis in a sample of 153 patients diagnosed with probable AD. Using factor scores, patients were classified into groups exhibiting asymmetric or symmetric profiles of neuropsychological deficits. In the analysis of lateral asymmetry, 27.5% of patients were classified as asymmetric (10% verbally and 17% visuospatially). Consistent with reports of continued asymmetry beyond the mild dementia stage, asymmetry was exhibited in the mild, moderate, and severely demented groups. These findings of neuropsychological asymmetry across stages of dementia are consistent with the picture of significant neuropsychological heterogeneity in AD that has been emerging in the decade. (JINS, 1997, 3, 420–427.)

scholarly journals RELIABILITY AND VALIDITY OF THE QUALITY OF LIFE-ALZHEIMER’S DISEASE QUESTIONNAIRE IN MALAY LANGUAGE FOR MALAYSIAN OLDER ADULT WITH DEMENTIA

2019 ◽  
Vol 19 (1) ◽  
pp. 56-63
Author(s):  
Kwai Ching Kan ◽  
Ponnusamy Subramaniam ◽  
Rosdinom Razali ◽  
Shazli Ezzat Ghazali
Keyword(s):  
Quality Of Life ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Factor Analysis ◽  
Reliability And Validity ◽  
Principal Component ◽  
Principal Component Factor Analysis ◽  
Component Factor ◽  
Moderate Dementia

The Quality of Life-Alzheimer’s Disease (QOL-AD) questionnaire is a reliable, valid and popular outcome measure in dementia related studies. However, to date there is no published report on adopted version of QOL-AD in Malay language. Thus this preliminary study aimed to evaluate the reliability and validity of the QOL-AD in Malay language for patients with dementia and to examine the level of agreement between patient-caregiver as a proxy reports on patient’s quality of life. A total of 65 patients with mild to moderate dementia and their caregivers were recruited from the psycho-geriatric clinic, Universiti Kebangsaan Malaysia Medical Centre using a cross sectional study design. The QOL-AD was translated into Malay language using the standard guidelines for cross-cultural adaptation of measure. The patient-caregiver dyads completed the QOL-AD in Malay language separately. Test-retest and internal consistency was evaluated for reliability and construct validity was tested with principal component factor analysis. The reliability of QOL-AD in Malay language was good with Cronbach alpha coefficients of 0.82 and 0.79 and intraclass correlation coefficients of 0.77 and 0.89 for patients and caregivers report respectively. Meanwhile a positive moderate agreement was achieved between patient and caregiver rating (r=0.60, p<0.01). The principal component factor analysis extracted 4 factors for both patient and caregiver reports which explained 66.02% (patients’ report) and 64.24% (caregivers’ report) of the total variance of the scale. As a conclusion, the QOL-AD in Malay language is a reliable and valid tool to measure the quality of life of people with mild to moderate dementia.

Ecological Orientation of Tourists: An Empirical Investigation

2007 ◽  
Vol 7 (3-4) ◽  
pp. 161-175 ◽  
Author(s):  
Natan Uriely ◽  
Arie Reichel ◽  
Amir Shani
Keyword(s):  
Factor Analysis ◽  
Empirical Investigation ◽  
Principal Component ◽  
Successful Implementation ◽  
Principal Component Factor Analysis ◽  
Ecological Requirements ◽  
Ecological Features ◽  
Component Factor ◽  
Ecological Values ◽  
Strong Orientation

This study presents a tourist ecological orientation (TEO) construct based on the responses of participants who were asked to state the importance of various ecological features of planned tourist sites. The higher the TEO score, the more sensitive the person's attitudes toward the ecological requirements and responsibilities of tourist sites. A principal component factor analysis reveals two alternative dimensions of the TEO concept: ‘destination oriented’ and ‘visitor oriented’. The higher score that was given to the latter dimension supports the argument that successful implementation of ecological values at tourist sites requires a strong orientation towards consumer needs in addition to an ideological commitment to the environment. In addition, differences in ecological orientation patterns and structure were analysed along age and nationality.

Patterns of neuropsychiatric sub-syndromes in Brazilian and Norwegian patients with dementia

2012 ◽  
Vol 25 (2) ◽  
pp. 228-235 ◽  
Author(s):  
Annibal Truzzi ◽  
Ingun Ulstein ◽  
Letice Valente ◽  
Eliasz Engelhardt ◽  
Evandro Silva Freire Coutinho ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Factor Analysis ◽  
Motor Behavior ◽  
Neuropsychiatric Symptoms ◽  
Principal Component ◽  
Mixed Dementia ◽  
Cross Sectional ◽  
Brazilian Sample ◽  
Two Samples

ABSTRACTBackground: Neuropsychiatric symptoms (NPS) affect the majority of patients who have dementia. Neuropsychiatric sub-syndromes with symptoms that occur together and have common neurobiological correlates have been identified. There are scarce data regarding the comparison of the pattern of the neuropsychiatric sub-syndromes in distinct ethnical and cultural populations. We aim at comparing the pattern of the NPS, and the factor analysis of the Neuropsychiatric Inventory (NPI-10) in two samples of outpatients with dementia living in Brazil and Norway.Methods: This is a cross-sectional study. The sample consists of 168 Brazilian and 155 Norwegian demented patients from psychogeriatric facilities and community-based educational programs. Brazilian patients were diagnosed with Alzheimer's disease (63.7%), vascular dementia (15.5%), or mixed dementia (20.8%), whereas the diagnoses of Norwegian patients were Alzheimer's disease (97.4%) and mixed dementia (2.6%). Principal component analysis with the Varimax rotation was used for factor analysis of the NPI-10.Results: Apathy (80.4 %), agitation/aggression (45.8%), and aberrant motor behavior (45.8%) were the most common symptoms in the Brazilian sample. Apathy (72.3%), dysphoria (61.9%), and anxiety (52.3%) were the most frequent symptoms in the Norwegian sample. Factor analysis of the NPI-10 revealed three syndromes for the Brazilian (Psychosis, Mood, Psychomotor) and Norwegian (Psychosis, Mood, Frontal) groups.Conclusions: The frequency of individual NPS may differ among distinct populations. However, Psychosis and Depression are common sub-syndromes in diverse ethnical and cultural patients with dementia. Our findings support the syndromic approach for the clinical assessment of the patients with dementia.

Functional substituents α to 13C: topological correlation by perturbation of a focus and principal component factor analysis

1982 ◽  
Vol 23 (41) ◽  
pp. 4241-4244 ◽  
Author(s):  
Jean-Pierre Doucet ◽  
Shen Gang Yuan ◽  
Patrick Billon ◽  
Jacques-Emile Dubois
Keyword(s):  
Factor Analysis ◽  
Principal Component ◽  
Principal Component Factor Analysis ◽  
Component Factor

The Mini-Mental State Examination in Alzheimer's Disease and Multi-Infarct Dementia

1996 ◽  
Vol 8 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Eugenio Magni ◽  
Giuliano Binetti ◽  
Alessandro Padovani ◽  
Stefano F. Cappa ◽  
Angelo Bianchetti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Principal Component ◽  
Principal Component Factor Analysis ◽  
Attentional Deficits ◽  
Main Components ◽  
External Stimuli ◽  
State Examination

The aim of this study was to compare the performances on each item of the Mini-Mental State Examination (MMSE) of patients with Alzheimer's disease (AD) and multi-infarct dementia (MID). In order to identify the items that could better distinguish the two groups of patients, 70 AD and 31 MID patients matched for disease severity, age, and education were evaluated. The scores of the 101 patients on each of the MMSE items were entered into a principal component factor analysis using varimax rotation, and two main components were derived. Component 1 was probably representative of recently acquired information, whereas component 2 represented educational level. A score summing the items that loaded on component 1 and the recall item was calculated to generate a measure of episodic memory. Performing analysis of variance and covarying for age and education revealed that this score was statistically different in the two groups, with AD patients having lower values. The data suggest that the MMSE may demonstrate a pattern of impairment of memory that differs between AD and MID. Possible explanations of this finding should take into account the different neuroanatomical impairments and the different degrees of motivation, due to depression or attentional deficits, toward external stimuli.

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