scholarly journals Early Computer Music Experiments in Australia and England

2017 ◽  
Vol 22 (2) ◽  
pp. 297-307 ◽  
Author(s):  
Paul Doornbusch
Keyword(s):  
Real Time ◽  
Computer Music ◽  
Industrial Research ◽  
History Of Computing ◽  
Automatic Computer ◽  
Early Computer ◽  
The Usa ◽  
History Of ◽  
Computing Machines

This article documents the early experiments in both Australia and England to make a computer play music. The experiments in England with the Ferranti Mark 1 and the Pilot ACE (practically undocumented at the writing of this article) and those in Australia with CSIRAC (Council for Scientific and Industrial Research Automatic Computer) are the oldest known examples of using a computer to play music. Significantly, they occurred some six years before the experiments at Bell Labs in the USA. Furthermore, the computers played music in real time. These developments were important, and despite not directly leading to later highly significant developments such as those at Bell Labs under the direction of Max Mathews, these forward-thinking developments in England and Australia show a history of computing machines being used musically since the earliest development of those machines.1

The ubiquitous Mr Babbage

1995 ◽  
Vol 49 (2) ◽  
pp. 341-342 ◽  
Keyword(s):  
19Th Century ◽  
Karl Marx ◽  
Critical Survey ◽  
History Of Computing ◽  
History Of Economics ◽  
History Of ◽  
Secure Place ◽  
The 19Th Century ◽  
Computing Machines

Charles Babbage, Passages from the Life of a Philosopher (ed. M. CampbellKelly). London. Pickering and Chatto, 1994. Pp. 392, £12.95. ISBN 185196 040 6 The text for this new edition of Passages from the Life of a Philospher was first prepared by Dr Campbell- Kelly for the monumental edition of the complete works of Charles Babbage which he edited and which appeared in 1988 under the imprint of Pickering Masters. Its publication as a separate volume is said to be much welcomed as making the work readily available to the growing circle of those interested in the history of computing and in science in the 19th century. Campbell-Kelly has written, specially for this edition, an excellent introduction running to some 12,000 words and containing a critical survey of Babbage’s career and achievements. He points out that Babbage would not be today celebrated as the ‘Pioneer of the Computer’ were it not for the enormous importance that computers have assumed in the second half of this century. However, he goes on to say that Babbage, even by the standards of his day, was a considerable polymath, and that there is much of interest in his life apart from computing machines. During the last decade or two, Babbage scholarship has begun to illuminate his full intellectual range. His most positive achievement was to put together a book entitled On the Economy of Machinery and Manufactures . This was quoted by various writers, including Karl Marx and J.S. Mill, and gives him a modest but secure place in the history of economics.

Socio-Technological Aspects of Automation in Public Works Activities

1987 ◽  
Vol 19 (3-4) ◽  
pp. 633-643
Author(s):  
William F. Garber
Keyword(s):  
Industrial Revolution ◽  
Work Force ◽  
Public Works ◽  
Human Society ◽  
Training Problem ◽  
Total Employment ◽  
The Usa ◽  
History Of ◽  
Complete Automation ◽  
The Impact

The history of human society is replete with examples of advances in technology overrunning the ability of societal organizations to efficiently handle the resulting massive societal dislocations. The social impacts of the “Industrial Revolution of the 18th and 19th Centuries” illustrate how profound such effects can be. The automation-computer-robotics revolution now underway also has the potential for serious societal changes. In this regard public works activities are subject to increasing amounts of automation with impacts upon current and net total employment and training needs. To evaluate the present status of automation in the USA, questionnaires were sent to public works authorities in 110 cities or agencies. The current degree of automation, the impact upon employment and the skills now needed by public works employers were queried. It was found that in most cases automation was just starting; but that as complete automation as was possible was inevitable given the increasing complexity of the tasks, the demands of the public and the long term prospects for public works funding. In many cases the candidates now in the work force were not properly trained for automation needs. Retraining and changes in the educational system appeared necessary if the employees now needed were to be continuously available. Public works management as well as several labor organizations appeared to be aware of this need and were organizing to handle the training problem and the changes in employment qualifications now necessary. It appeared to be a consensus that the larger societal effects of automation should be handled by society as a whole.

The design of a history of computing course with a unique perspective

2006 ◽  
Vol 38 (1) ◽  
pp. 67-71 ◽  
Author(s):  
Thomas J. Cortina ◽  
Richard McKenna
Keyword(s):  
History Of Computing ◽  
History Of

scholarly journals A “Smart” Biosensor-Enabled Intravascular Catheter and Platform for Dynamic Delivery of Propofol to “Close the Loop” for Total Intravenous Anesthesia

2021 ◽  
Vol 186 (Supplement_1) ◽  
pp. 370-377
Author(s):  
Edward Chaum ◽  
Ernő Lindner
Keyword(s):  
Real Time ◽  
Drug Distribution ◽  
Population Based ◽  
Pharmacokinetic Data ◽  
Drug Infusion ◽  
Blood Concentrations ◽  
The Usa ◽  
The Difference ◽  
Automated Delivery

ABSTRACT Background Target-controlled infusion anesthesia is used worldwide to provide user-defined, stable, blood concentrations of propofol for sedation and anesthesia. The drug infusion is controlled by a microprocessor that uses population-based pharmacokinetic data and patient biometrics to estimate the required infusion rate to replace losses from the blood compartment due to drug distribution and metabolism. The objective of the research was to develop and validate a method to detect and quantify propofol levels in the blood, to improve the safety of propofol use, and to demonstrate a pathway for regulatory approval for its use in the USA. Methods We conceptualized and prototyped a novel “smart” biosensor-enabled intravenous catheter capable of quantifying propofol at physiologic levels in the blood, in real time. The clinical embodiment of the platform is comprised of a “smart” biosensor-enabled catheter prototype, a signal generation/detection readout display, and a driving electronics software. The biosensor was validated in vitro using a variety of electrochemical methods in both static and flow systems with biofluids, including blood. Results We present data demonstrating the experimental detection and quantification of propofol at sub-micromolar concentrations using this biosensor and method. Detection of the drug is rapid and stable with negligible biofouling due to the sensor coating. It shows a linear correlation with mass spectroscopy methods. An intuitive graphical user interface was developed to: (1) detect and quantify the propofol sensor signal, (2) determine the difference between targeted and actual propofol concentration, (3) communicate the variance in real time, and (4) use the output of the controller to drive drug delivery from an in-line syringe pump. The automated delivery and maintenance of propofol levels was demonstrated in a modeled benchtop “patient” applying the known pharmacokinetics of the drug using published algorithms. Conclusions We present a proof-of-concept and in vitro validation of accurate electrochemical quantification of propofol directly from the blood and the design and prototyping of a “smart,” indwelling, biosensor-enabled catheter and demonstrate feedback hardware and software architecture permitting accurate measurement of propofol in blood in real time. The controller platform is shown to permit autonomous, “closed-loop” delivery of the drug and maintenance of user-defined propofol levels in a dynamic flow model.

Economics of respiratory disease in dairy replacement heifers

2020 ◽  
Vol 21 (2) ◽  
pp. 143-148
Author(s):  
Michael W. Overton
Keyword(s):  
Respiratory Disease ◽  
Milk Production ◽  
Incident Case ◽  
Data Set ◽  
Dairy Heifers ◽  
The Usa ◽  
History Of ◽  
On Farm ◽  
The Impact ◽  
Selective Culling

AbstractBovine respiratory disease (BRD) is a frequent disease concern in dairy cattle and is most commonly diagnosed in young dairy heifers. The impact of BRD is highly variable, depending on the accuracy and completeness of detection, effectiveness of treatment, and on-farm culling practices. Consequences include decreased rate of weight gain, a higher culling risk either as heifers or as cows, delayed age at first service, delayed age at first calving, and in some cases, lower future milk production. In this data set of 104,100 dairy replacement heifers from across the USA, 36.6% had one or more cases diagnosed within the first 120 days of age with the highest risk of new cases occurring prior to weaning. Comparison of the raising cost for heifers with BRD and those without a recorded history of BRD resulted in an estimated cost per incident case occurring in the first 120 days of age of $252 or $282, depending upon whether anticipated future milk production differences were considered or not. Current market conditions contributed to a cost estimate that is significantly higher than previously published estimates, driven in part by the losses associated with selective culling of a subset of heifers that experienced BRD.

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