scholarly journals Active immunization against GnRH in pre-pubertal domestic mammals: testicular morphometry, histopathology and endocrine responses in rabbits, guinea pigs and ram lambs

animal ◽  
2018 ◽  
Vol 12 (4) ◽  
pp. 784-793 ◽  
Author(s):  
P.M. Aponte ◽  
M.A. Gutierrez-Reinoso ◽  
E.G. Sanchez-Cepeda ◽  
M. Garcia-Herreros
Keyword(s):  
Guinea Pigs ◽  
Active Immunization ◽  
Ram Lambs

Responses of ram lambs to active immunization against testosterone and luteinizing hormone-releasing hormone

1982 ◽  
Vol 242 (3) ◽  
pp. E201-E205 ◽  
Author(s):  
B. D. Schanbacher
Keyword(s):  
Luteinizing Hormone ◽  
Live Weight ◽  
Active Immunization ◽  
High Serum ◽  
Testicular Development ◽  
Serum Concentrations ◽  
Luteinizing Hormone Releasing Hormone ◽  
Releasing Hormone ◽  
Antibody Titers ◽  
Ram Lambs

Active immunization of young ram lambs against testosterone and luteinizing hormone-releasing hormone (LHRH) was shown to block the growth attributes characteristic of intact ram lambs. Testosterone and LHRH-immunized lambs grew at a slower rate and converted feed to live weight gain less efficiently than albumin-immunized controls. Lambs immunized against testosterone and LHRH had high antibody titers for their respective antigens. Moreover, testosterone-immunized lambs had high serum concentrations of luteinizing hormone (LH) and testosterone, whereas LHRH-immunized lambs had low to nondetectable serum concentrations of these hormones. Release of LH and testosterone following the intravenous administration of LHRH (250 ng) was absent in LHRH-immunized lambs, but quantitatively similar for intact and albumin-immunized control lambs. Testosterone-immunized lambs responded as did conventional castrates with a large LH release, but testosterone concentrations were unchanged. These findings are discussed relative to the integrity of the hypothalamic-pituitary-testicular endocrine axis and the importance of gonadotropin support for normal testicular development. These data show that LHRH immunoneutralization effectively retards testicular development and produces a castration effect in young ram lambs.

scholarly journals STUDIES ON TYPHUS FEVER

1931 ◽  
Vol 53 (4) ◽  
pp. 493-497 ◽  
Author(s):  
Hans Zinsser ◽  
M. Ruiz Castaneda
Keyword(s):  
Guinea Pigs ◽  
Spotted Fever ◽  
Rocky Mountain ◽  
Active Immunization ◽  
Rocky Mountain Spotted Fever ◽  
Typhus Fever

Guinea pigs can be immunized against Mexican typhus virus by peritoneal injections of formalinized Rickettsia material, provided sufficient amounts of the organisms are used. Our results in this respect are analogous to those of Spencer and Parker with carbolized virus of Rocky Mountain spotted fever. The Rickettsia suspensions appear to possess considerable toxicity. We do not wish to be misunderstood as implying that the results in guinea pigs offer anything more than a demonstration of the principle of active immunization with killed Rickettsiae. Application to man will have to be worked out, and preliminary to this, we are now attempting to apply the methods to a limited number of monkeys.

scholarly journals The Active Immunization of Guinea-Pigs Passively Immunized with Homologous Antitoxic Serum

1955 ◽  
Vol 53 (2) ◽  
pp. 172-179 ◽  
Author(s):  
J. H. Mason ◽  
Mary Robinson ◽  
P. Agerholm Christensen
Keyword(s):  
Guinea Pigs ◽  
Diphtheria Toxin ◽  
Active Immunization ◽  
The Other ◽  
Control Groups ◽  
Large Measure ◽  
Primary Stimulus ◽  
Serum Titre ◽  
Secondary Stimulus

SummaryGroups of guinea-pigs were passively immunized against diphtheria toxin with homologous antitoxic serum so that their sera contained, at the start of the experiment, 1·0, 0·1, 0·01 or 0·001 unit/ml, respectively. They were then actively immunized with one, or two spaced, injections of 0·1 Lf of A.D.F. Two control groups were included, one passively immunized only and the other actively immunized only.Passively produced serum titres of 0·01 and 0·001 unit/ml. did not interfere with active immunization in any demonstrable way.A titre of 0·1 unit/ml. did interfere with active immunization, markedly 4 weeks after the primary, slightly 2 weeks after the secondary, and markedly 14 weeks after the secondary, stimulus.A titre of 1·0 unit/ml. interfered with active immunization, markedly 4 weeks after the primary, and 2 and 14 weeks after the secondary, stimulus. This titre, however, did not completely annul the effect of the primary stimulus. The highest observed serum titre was obtained at the 32nd, instead of at the 4th week, as in the guinea-pigs actively immunized only.In large measure the results confirm those of Barr and her colleagues who found that, in human babies, an initial ‘passive’ titre of 0·04 unit/ml. serum did not interfere with active immunization, whereas a titre of 0·1 unit/ml, led to unsatisfactory immunization.

Sexual development and the effects of active immunization against GnRH in Chinese Tanyang ram lambs

2003 ◽  
Vol 77 (3-4) ◽  
pp. 129-139 ◽  
Author(s):  
S. Cui ◽  
Y.F. Chen ◽  
H.N. Yue ◽  
Y.Q. He ◽  
A.S. McNeilly
Keyword(s):  
Sexual Development ◽  
Active Immunization ◽  
Ram Lambs

Follicle selection in cyclic guinea pigs with active immunization against inhibin α-subunit

Life Sciences ◽  
2000 ◽  
Vol 66 (25) ◽  
pp. 2489-2497 ◽  
Author(s):  
FangXiong Shi ◽  
Keiji Mochida ◽  
Atsuo Ogura ◽  
Junichiro Matsuda ◽  
Osamu Suzuki ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Active Immunization ◽  
Α Subunit ◽  
Follicle Selection

scholarly journals ACTIVE IMMUNIZATION OF GUINEA PIGS WITH THE VIRUS OF EQUINE ENCEPHALOMYELITIS

1936 ◽  
Vol 63 (5) ◽  
pp. 745-765 ◽  
Author(s):  
Herald R. Cox ◽  
Peter K. Olitsky
Keyword(s):  
Induced Resistance ◽  
Guinea Pigs ◽  
Quantitative Methods ◽  
Active Immunization ◽  
Active Virus ◽  
High Degree

From a study by quantitative methods, the conclusion is reached that a resistance of high degree may be induced in guinea pigs and mice against experimental equine encephalomyelitis by means of formolized vaccines in which no active virus can be demonstrated. The induced resistance is not due to residual traces of active virus which might possibly have escaped detection in the formolized tissue preparations.

scholarly journals STUDIES ON TYPHUS FEVER

1931 ◽  
Vol 53 (3) ◽  
pp. 333-338 ◽  
Author(s):  
Hans Zinsser ◽  
M. Ruiz Castaneda ◽  
C. V. Seastone
Keyword(s):  
Tissue Culture ◽  
Guinea Pigs ◽  
Preceding Paper ◽  
Severe Infection ◽  
Active Immunization ◽  
Point Of View ◽  
Deficiency Symptoms ◽  
Clinical Pictures ◽  
Typhus Fever

The above experiments demonstrate that guinea pigs and rats subjected to vitamin-deficient diets to a point at which deficiency symptoms appear, and then inoculated with typhus virus, exhibit clinical pictures which indicate a far more severe infection than that observed in normal animals after inoculation. There is also a wider distribution of Rickettsiae and a concentration of organisms which, in pleural and peritoneal exudates, amounts to almost cultural proportions. Important from our point of view is the fact that these experiments furnished a step toward the accomplishment of our purpose, which was to obtain amounts and concentrations of Rickettsiae suitable for immunological studies until such a time when tissue culture may have developed to a practically useful stage. The experiments are of immediate importance in that they furnish us a method for improving our technique of active immunization reported upon in the preceding paper, No. V (8). From the epidemiological point of view these experiments at least suggest an explanation of one of the important factors which enter into the historical association of high typhus mortality with war and famine.

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