A chip based mass spectrometer technology promises to offer smart-device autonomous microsystem chemical analysis capability for sample determination and process monitoring for multiple applications in a small low power instrument package. This project focuses on the development of cylindrical ion trap mass analyzer chips fabricated using 3D Additive Manufacturing and planar Low Temperature Co-Fired Ceramic thick film processes toward the realization of a chip based mass spectrometer microsystem. The cylindrical ion trap (CIT) is a mass analyzer comprised of planar electrodes and operates by trapping and ejecting sample ions based on their mass in an RF field. Because of its simplicity CITs may be easily miniaturized and connected in tandem to achieve multiplexing. Additive manufacturing materials and methods enable enhanced trap miniaturization through micro machining and electrode patterning methods, fast and cost effective prototyping, batch fabrication, and material formulation flexibility. The current design incorporates three parallel ceramic plate metalized electrodes making up a singular trap geometry in a 10mm2 ceramic chip, forming a mass analyzer of reduced size, mass, and power, with enhanced material robustness for extended range use and in harsh environments. Unique processes have been developed to produce these devices which include conformal metallization layers, adhesion layers, ceramic paste formulations, sacrificial supporting materials, and co-firing methods. Additionally, 3D printing brings a unique design and fabrication capability enabling novel structures, material blending and heterogeneous integration. With true digital control, the designs are easily scalable and shape agnostic.
High-Throughput LC/MS/MS Analysis of Ruscogenin and Neoruscogenin in Ruscus aculeatus L.