scholarly journals Pair of Stereodynamic Chiral Benzylicaldehyde Probes for Determination of Absolute Configuration of Amino Acid Residues in Peptides by Mass Spectrometry

2017 ◽  
Vol 89 (22) ◽  
pp. 11902-11907 ◽  
Author(s):  
Lin Wang ◽  
Zhe Jin ◽  
Xiayan Wang ◽  
Su Zeng ◽  
Cuirong Sun ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Absolute Configuration ◽  
Amino Acid Residues ◽  
Determination Of Absolute Configuration

Determination of the Complete Absolute Configuration of Petriellin A

2006 ◽  
Vol 59 (6) ◽  
pp. 407 ◽  
Author(s):  
Luigi Aurelio ◽  
Robert T. C. Brownlee ◽  
Jason Dang ◽  
Andrew B. Hughes ◽  
Gideon M. Polya
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Natural Product ◽  
Absolute Configuration ◽  
Structural Determination ◽  
Amino Acid Residues ◽  
The Common ◽  
The Absolute ◽  
Derivatives Of

We report the full structural determination of the depsipeptide petriellin A. The absolute configuration of the amino acid residues, N-methyl isoleucine and N-methyl threonine, have been determined by a combination of HPLC and TLC comparison of synthetic Marfey’s derivatives and Marfey’s derivatives of the natural product hydrolysate. The configuration of the chiral centres in these two N-methylated residues was found to be the same as those of the common unmethylated l-amino acids.

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