Molecular Mechanism of Light-Induced Conformational Switching of the LOV Domain in Aureochrome-1

Biochemistry ◽  
2020 ◽  
Vol 59 (28) ◽  
pp. 2592-2601 ◽  
Author(s):  
Itsuki Kobayashi ◽  
Hiroto Nakajima ◽  
Osamu Hisatomi
Keyword(s):  
Molecular Mechanism ◽  
Lov Domain ◽  
Conformational Switching

scholarly journals Targeted dynein inhibition generates flagellar beating

2017 ◽  
Author(s):  
Jianfeng Lin ◽  
Daniela Nicastro
Keyword(s):  
Molecular Mechanism ◽  
Structural Changes ◽  
Direct Evidence ◽  
Electron Tomography ◽  
Asymmetric Distribution ◽  
Conformational Switching ◽  
Cryo Electron Tomography ◽  
Cilia And Flagella ◽  
Biochemical Analyses ◽  
Sea Urchin Sperm

Motile cilia and flagella are highly conserved organelles that are essential for the normal development and health of many eukaryotes including humans. To reveal the molecular mechanism of motility, we used cryo-electron tomography of active sea urchin sperm flagella to directly visualize the macromolecular complexes and their structural changes during flagellar beating. We resolved distinct conformations of dynein motors and regulators, and showed that many of them are distributed in bend-direction-dependent fashion in active flagella. Our results provide direct evidence for the conformational switching predicted by the ‘switch-point-hypothesis’. However, they also reveal a fundamentally different mechanism of generating motility by inhibiting dyneins, rather than activating them, causing an asymmetric distribution of force and thus bending. Our high-resolution structural and biochemical analyses provide a new understanding of the distinct roles played by various dyneins and regulators in ciliary motility and suggest a molecular mechanism for robust beating in an all-or-none manner.

scholarly journals Molecular Mechanism of Conformational Switching that Regulates Helicase Function

2020 ◽  
Vol 118 (3) ◽  
pp. 71a-72a
Author(s):  
Wen Ma ◽  
Sean Carney ◽  
Yann R. Chemla ◽  
Zaida Luthey-Schulten ◽  
J. Andrew McCammon
Keyword(s):  
Molecular Mechanism ◽  
Conformational Switching

Additional evidence for AQP1 vesicle trafficking as a molecular mechanism for ductal bile secretion

2001 ◽  
Vol 120 (5) ◽  
pp. A91-A91
Author(s):  
P TIETZ ◽  
P SPLINTER ◽  
M MCNIVEN ◽  
R HUEBERT ◽  
N LARUSSO
Keyword(s):  
Molecular Mechanism ◽  
Vesicle Trafficking ◽  
Bile Secretion

Hypoxia/Reoxygenation on human myometrial and decidual cells: A molecular mechanism involved in preterra labor

1998 ◽  
Vol 5 (1) ◽  
pp. 187A-187A
Author(s):  
J CARVAJAL ◽  
S KATO ◽  
J SAEZ ◽  
F LEIGHTON ◽  
G VALENZUELA ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Decidual Cells ◽  
Hypoxia Reoxygenation

Molecular Mechanism of Apoptosis Induction by Resveratrol, a Natural Cancer Chemopreventive Agent

2008 ◽  
Vol 78 (1) ◽  
pp. 3-8 ◽  
Author(s):  
Fan ◽  
Jiang ◽  
Zhang ◽  
Bai
Keyword(s):  
Cancer Treatment ◽  
Molecular Mechanism ◽  
Apoptosis Induction ◽  
Protective Agents ◽  
Chemopreventive Agent ◽  
Naturally Occurring ◽  
Apoptosis Pathways ◽  
Present Understanding

In efforts to identify naturally occurring compounds that act as protective agents, resveratrol, a phytoalexin existing in wine, has attracted much interest because of its diverse pharmacological characteristics. Considering that apoptosis induction is the most potent defense approach for cancer treatment, we have tried to summarize our present understanding of apoptosis induction by resveratrol based on the two major apoptosis pathways.

Molecular mechanism of hippocampal injury: Roles of glucocorticoids and cytokines

2000 ◽  
Vol 38 ◽  
pp. S17
Author(s):  
I Hideki
Keyword(s):  
Molecular Mechanism

The molecular mechanism of Silexan: Neurotrophic effects via CREB activation might explain preclinical antidepressant properties

2013 ◽  
Vol 46 (06) ◽  
Author(s):  
G Sillani ◽  
C Schiller ◽  
K Leuner ◽  
WE Müller
Keyword(s):  
Molecular Mechanism ◽  
Creb Activation

The molecular mechanism of n-butanol extracts of Panax notoginseng on RANKL-induced osteoclastogenesis in RAW264.7 cells

2014 ◽  
Author(s):  
Hyo-In Hwang ◽  
Young-Joo Jang ◽  
Seon-Yle Ko
Keyword(s):  
Molecular Mechanism ◽  
Panax Notoginseng ◽  
Raw264.7 Cells
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