Exploring Solid Form Landscape of Anticancer Drug Dimethylaminomicheliolide Fumarate: Crystal Structures Analysis, Phase Transformation Behavior, and Physicochemical Properties Characterization

2021 ◽  
Author(s):  
Zhonghua Li ◽  
Lingyu Wang ◽  
Ying Wang ◽  
Songgu Wu ◽  
Junbo Gong
Keyword(s):  
Phase Transformation ◽  
Physicochemical Properties ◽  
Crystal Structures ◽  
Anticancer Drug ◽  
Transformation Behavior ◽  
Phase Transformation Behavior ◽  
Analysis Phase ◽  
Solid Form ◽  
Properties Characterization

Exploring the solid form landscape of antifungal drug Isavuconazole: crystal structure analysis, phase transformation behavior and dissolution performance

CrystEngComm ◽  
2021 ◽  
Author(s):  
Alexander P. Voronin ◽  
Nikita Vasilev ◽  
Artem Olegovich Surov ◽  
Churakov Andrei ◽  
German L. Perlovich
Keyword(s):  
Crystal Structure ◽  
Phase Transformation ◽  
Invasive Aspergillosis ◽  
Structure Analysis ◽  
Antifungal Agent ◽  
Dosage Forms ◽  
Crystal Structure Analysis ◽  
Transformation Behavior ◽  
Analysis Phase ◽  
Solid Form

Isavuconazole (ISV) is a systemic antifungal agent which is used to treat invasive aspergillosis, mucormicosis and candidiasis. Although both oral and intravenous dosage forms of this drug exist on the...

Dimorphism and inclusion compounds of N,N′-di(benzenesulfonyl)-p-phenylenediamine

2000 ◽  
Vol 56 (2) ◽  
pp. 234-244 ◽  
Author(s):  
Norbert Nagel ◽  
Hans Bock ◽  
Peter Eller
Keyword(s):  
Differential Scanning Calorimetry ◽  
Phase Transformation ◽  
Crystal Structures ◽  
Inclusion Compounds ◽  
Transformation Behavior ◽  
Scanning Calorimetry ◽  
Phase Transformation Behavior ◽  
Crystallization Conditions

Crystal structures of a new polymorph of N,N′-(p-phenylene)bis(benzenesulfonamide) (C18H16N2O4S2) and of two inclusion compounds with acetone [(CH3)2CO] and dimethylsulfoxide [2(CH3)2SO], respectively, have been determined at 150 K. For a more reliable comparison, the structure of the already known polymorph of N,N′-di(benzenesulfonyl)-p-phenylenediamine has been redetermined under identical conditions. In addition, the phase transformation behavior has been examined by differential scanning calorimetry and the crystallization conditions of both polymorphs including their formation by weathering of the inclusion compounds were investigated.

Evolution of Phase Transformation Behavior in Li(Mn1.5Ni0.5)O4 Cathodes Studied By In Situ XRD

2011 ◽  
Vol 158 (8) ◽  
pp. A890 ◽  
Author(s):  
Kevin Rhodes ◽  
Roberta Meisner ◽  
Yoongu Kim ◽  
Nancy Dudney ◽  
Claus Daniel
Keyword(s):  
Phase Transformation ◽  
Transformation Behavior ◽  
Phase Transformation Behavior ◽  
In Situ Xrd

Cracking and Phase Transformation in Silicon During Nanoindentation

2003 ◽  
Vol 795 ◽  
Author(s):  
Jae-il Jang ◽  
Songqing Wen ◽  
M. J. Lance ◽  
I. M. Anderson ◽  
G. M. Pharr
Keyword(s):  
Raman Spectroscopy ◽  
Phase Transformation ◽  
Single Crystals ◽  
Transformation Behavior ◽  
Amorphous Phases ◽  
Phase Transformation Behavior ◽  
Wide Range ◽  
Load Displacement ◽  
Indenter Geometry

ABSTRACTNanoindentation experiments were performed on single crystals of (100) Si using a series of triangular pyramidal indenters with centerline-to-face angles in the range 35.3° to 85.0°. The influences of the indenter geometry on cracking and phase transformation during indentation were systematically studied. Although reducing the indenter angle reduces the threshold load for cracking and increases the crack lengths, c, at a given indention load, P, the frequently observed relation between P and c3/2 is maintained for all of the indenters over a wide range of load. Features in the nanoindentation load-displacement curves in conjunction with Raman spectroscopy of the crystalline and amorphous phases in and around the contact impression show that the indenter geometry also plays a role in the phase transformation behavior. Results are discussed in relation to prevailing ideas about indentation cracking and phase transformation in silicon.

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