Rapid Assessment of the Physical Stability of Amorphous Solid Dispersions

Prediction of the physical stability of amorphous solid dispersions: relationship of aging and phase separation with the thermodynamic and kinetic models along with characterization techniques

Expert Opinion on Drug Delivery ◽

10.1080/17425247.2021.1844181 ◽

2020 ◽

pp. 1-16

Author(s):

Zhaoyang Zhang ◽

Luning Dong ◽

Jueshuo Guo ◽

Li Li ◽

Bin Tian ◽

...

Keyword(s):

Phase Separation ◽

Kinetic Models ◽

Solid Dispersions ◽

Physical Stability ◽

Amorphous Solid ◽

Characterization Techniques ◽

Relationship Of

A Practical Method to Predict Physical Stability of Amorphous Solid Dispersions

Pharmaceutical Research ◽

10.1007/s11095-012-0717-5 ◽

2012 ◽

Vol 29 (10) ◽

pp. 2792-2805 ◽

Cited By ~ 36

Author(s):

Stéphanie Greco ◽

Jean-René Authelin ◽

Caroline Leveder ◽

Audrey Segalini

Keyword(s):

Solid Dispersions ◽

Physical Stability ◽

Amorphous Solid ◽

Practical Method ◽

Investigating the Correlation between Miscibility and Physical Stability of Amorphous Solid Dispersions Using Fluorescence-Based Techniques

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.6b00803 ◽

2016 ◽

Vol 13 (11) ◽

pp. 3988-4000 ◽

Cited By ~ 32

Author(s):

Bin Tian ◽

Xing Tang ◽

Lynne S. Taylor

Keyword(s):

Solid Dispersions ◽

Physical Stability ◽

Amorphous Solid ◽

Use of a Plasticizer for Physical Stability Prediction of Amorphous Solid Dispersions

Crystal Growth & Design ◽

10.1021/acs.cgd.7b00625 ◽

2017 ◽

Vol 17 (8) ◽

pp. 4315-4325 ◽

Cited By ~ 16

Author(s):

Michelle H. Fung ◽

Raj Suryanarayanan

Keyword(s):

Solid Dispersions ◽

Physical Stability ◽

Amorphous Solid ◽

Stability Prediction ◽

Physical stability of API/polymer-blend amorphous solid dispersions

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2017.12.002 ◽

2018 ◽

Vol 124 ◽

pp. 147-157 ◽

Cited By ~ 26

Author(s):

Kristin Lehmkemper ◽

Samuel O. Kyeremateng ◽

Mareike Bartels ◽

Matthias Degenhardt ◽

Gabriele Sadowski

Keyword(s):

Polymer Blend ◽

Solid Dispersions ◽

Physical Stability ◽

Amorphous Solid ◽

Impact of Polymer Type and Relative Humidity on the Long-Term Physical Stability of Amorphous Solid Dispersions

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.7b00492 ◽

2017 ◽

Vol 14 (12) ◽

pp. 4374-4386 ◽

Cited By ~ 36

Author(s):

Kristin Lehmkemper ◽

Samuel O. Kyeremateng ◽

Oliver Heinzerling ◽

Matthias Degenhardt ◽

Gabriele Sadowski

Keyword(s):

Relative Humidity ◽

Solid Dispersions ◽

Physical Stability ◽

Amorphous Solid ◽

Polymer Type

Physical stability of l -ascorbic acid amorphous solid dispersions in different polymers: A study of polymer crystallization inhibitor properties

Food Research International ◽

10.1016/j.foodres.2015.08.009 ◽

2015 ◽

Vol 76 ◽

pp. 867-877 ◽

Cited By ~ 15

Author(s):

Belinda Christina ◽

Lynne S. Taylor ◽

Lisa J. Mauer

Keyword(s):

Ascorbic Acid ◽

Solid Dispersions ◽

Physical Stability ◽

Amorphous Solid ◽

Polymer Crystallization ◽

Crystallization Inhibitor

Influence of mechanical and thermal energy on nifedipine amorphous solid dispersions prepared by hot melt extrusion: Preparation and physical stability

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2019.03.014 ◽

2019 ◽

Vol 561 ◽

pp. 324-334 ◽

Cited By ~ 15

Author(s):

Xiangyu Ma ◽

Siyuan Huang ◽

Michael B. Lowinger ◽

Xu Liu ◽

Xingyu Lu ◽

...

Keyword(s):

Thermal Energy ◽

Solid Dispersions ◽

Physical Stability ◽

Amorphous Solid ◽

Hot Melt Extrusion ◽

Melt Extrusion ◽

Hot Melt

Physical stability of hydroxypropyl methylcellulose-based amorphous solid dispersions: Experimental and computational study

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2020.119845 ◽

2020 ◽

Vol 589 ◽

pp. 119845 ◽

Cited By ~ 2

Author(s):

Anton Iemtsev ◽

Fatima Hassouna ◽

Alex Mathers ◽

Martin Klajmon ◽

Marcela Dendisová ◽

...

Keyword(s):

Computational Study ◽

Solid Dispersions ◽

Hydroxypropyl Methylcellulose ◽

Physical Stability ◽

Amorphous Solid ◽

Effects of Dendrimer-Like Biopolymers on Physical Stability of Amorphous Solid Dispersions and Drug Permeability Across Caco-2 Cell Monolayers

AAPS PharmSciTech ◽

10.1208/s12249-018-1080-6 ◽

2018 ◽

Vol 19 (6) ◽

pp. 2459-2471 ◽

Cited By ~ 4

Author(s):

Monika Lavan ◽

Gregory Knipp

Keyword(s):

Solid Dispersions ◽

Physical Stability ◽

Amorphous Solid ◽

Drug Permeability ◽

Cell Monolayers