Fine Particulate Matter Constituents, Nitric Oxide Synthase DNA Methylation and Exhaled Nitric Oxide

2015 ◽  
Vol 49 (19) ◽  
pp. 11859-11865 ◽  
Author(s):  
Renjie Chen ◽  
Liping Qiao ◽  
Huichu Li ◽  
Yan Zhao ◽  
Yunhui Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Methylation ◽  
Particulate Matter ◽  
Nitric Oxide Synthase ◽  
Fine Particulate Matter ◽  
Exhaled Nitric Oxide ◽  
Fine Particulate ◽  
Oxide Synthase

scholarly journals Exposure to Household Air Pollution from Biomass Cookstoves and Levels of Fractional Exhaled Nitric Oxide (FeNO) among Honduran Women

2018 ◽  
Vol 15 (11) ◽  
pp. 2544 ◽  
Author(s):  
Megan Benka-Coker ◽  
Maggie Clark ◽  
Sarah Rajkumar ◽  
Bonnie Young ◽  
Annette Bachand ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Air Pollution ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Exhaled Nitric Oxide ◽  
Household Air Pollution ◽  
Fractional Exhaled Nitric Oxide ◽  
Cross Sectional ◽  
Premature Deaths ◽  
Fine Particulate

Household air pollution is estimated to be responsible for nearly three million premature deaths annually. Measuring fractional exhaled nitric oxide (FeNO) may improve the limited understanding of the association of household air pollution and airway inflammation. We evaluated the cross-sectional association of FeNO with exposure to household air pollution (24-h average kitchen and personal fine particulate matter and black carbon; stove type) among 139 women in rural Honduras using traditional stoves or cleaner-burning Justa stoves. We additionally evaluated interaction by age. Results were generally consistent with a null association; we did not observe a consistent pattern for interaction by age. Evidence from ambient and household air pollution regarding FeNO is inconsistent, and may be attributable to differing study populations, exposures, and FeNO measurement procedures (e.g., the flow rate used to measure FeNO).

scholarly journals Particulate Matter, DNA Methylation in Nitric Oxide Synthase, and Childhood Respiratory Disease

2012 ◽  
Vol 120 (9) ◽  
pp. 1320-1326 ◽  
Author(s):  
Carrie V. Breton ◽  
Muhammad T. Salam ◽  
Xinhui Wang ◽  
Hyang-Min Byun ◽  
Kimberly D. Siegmund ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Methylation ◽  
Particulate Matter ◽  
Nitric Oxide Synthase ◽  
Respiratory Disease ◽  
Oxide Synthase

scholarly journals DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Congrong Wang ◽  
Michelle Plusquin ◽  
Akram Ghantous ◽  
Zdenko Herceg ◽  
Rossella Alfano ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Particulate Matter ◽  
Growth Factor ◽  
Cord Blood ◽  
Gene Cluster ◽  
Methylation Level ◽  
Fine Particulate Matter ◽  
Methylation Status ◽  
Insulin Like Growth Factor ◽  
Fine Particulate

Abstract Background The IGF2 (insulin-like growth factor 2) and H19 gene cluster plays an important role during pregnancy as it promotes both foetal and placental growth. We investigated the association between cord blood DNA methylation status of the IGF2/H19 gene cluster and maternal fine particulate matter exposure during fetal life. To the best of our knowledge, this is the first study investigating the association between prenatal PM2.5 exposure and newborn DNA methylation of the IGF2/H19. Methods Cord blood DNA methylation status of IGF2/H19 cluster was measured in 189 mother-newborn pairs from the ENVIRONAGE birth cohort (Flanders, Belgium). We assessed the sex-specific association between residential PM2.5 exposure during pregnancy and the methylation level of CpG loci mapping to the IGF2/H19 cluster, and identified prenatal vulnerability by investigating susceptible time windows of exposure. We also addressed the biological functionality of DNA methylation level in the gene cluster. Results Prenatal PM2.5 exposure was found to have genetic region-specific significant association with IGF2 and H19 during specific gestational weeks. The association was found to be sex-specific in both gene regions. Functionality of the DNA methylation was annotated by the association to fetal growth and cellular pathways. Conclusions The results of our study provided evidence that prenatal PM2.5 exposure is associated with DNA methylation in newborns’ IGF2/H19. The consequences within the context of fetal development of future phenotyping should be addressed.

scholarly journals Long-term ambient fine particulate matter and DNA methylation in inflammation pathways: results from the Sister Study

Epigenetics ◽  
2019 ◽  
Vol 15 (5) ◽  
pp. 524-535
Author(s):  
Cuicui Wang ◽  
Katie M. O’Brien ◽  
Zongli Xu ◽  
Dale P. Sandler ◽  
Jack A. Taylor ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate
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