scholarly journals Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway

2017 ◽  
Vol 51 (19) ◽  
pp. 11423-11430 ◽  
Author(s):  
Lin-Ying Cao ◽  
Xiao-Min Ren ◽  
Chuan-Hai Li ◽  
Jing Zhang ◽  
Wei-Ping Qin ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
G Protein ◽  
Estrogenic Effects ◽  
Estrogen Receptor Pathway ◽  
G Protein Coupled ◽  
Bisphenol Af

scholarly journals Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating PKA and PKG via a Membrane G-Protein–Coupled Estrogen Receptor

2009 ◽  
Vol 117 (7) ◽  
pp. 1053-1058 ◽  
Author(s):  
Adil Bouskine ◽  
Marielle Nebout ◽  
Françoise Brücker-Davis ◽  
Mohamed Benahmed ◽  
Patrick Fenichel
Keyword(s):  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Bisphenol A ◽  
G Protein ◽  
Low Doses ◽  
G Protein Coupled

Tricresyl phosphate isomers exert estrogenic effects via G protein-coupled estrogen receptor-mediated pathways

2020 ◽  
Vol 264 ◽  
pp. 114747
Author(s):  
Xiaoya Ji ◽  
Na Li ◽  
Mei Ma ◽  
Kaifeng Rao ◽  
Rong Yang ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Tricresyl Phosphate ◽  
Estrogenic Effects ◽  
G Protein Coupled

Known and emerging factors modulating estrogenic effects of endocrine-disrupting chemicals

2014 ◽  
Vol 22 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Wanglong Zhang ◽  
Yu Luo ◽  
Li Zhang ◽  
Qian Cai ◽  
Xuejun Pan
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Posttranslational Modification ◽  
Splice Variants ◽  
Physiological Responses ◽  
Endocrine Disrupting Chemicals ◽  
Estrogenic Effects ◽  
Endocrine Disrupting ◽  
G Protein Coupled ◽  
Estrogen Receptor 1

A variety of endocrine-disrupting chemicals (EDCs) have estrogenic effects and are termed xenoestrogens (XEs). The genomic pathway mediated by estrogen receptors (ERs) has been considered the major explanation for the estrogenic effects elicited by XEs. Presently, nongenomic pathways have achieved considerably more attention because the genomic pathways cannot fully elucidate many biological and physiological responses. Genomic and nongenomic pathways act either separately or cooperatively. XEs activate a variety of signaling pathways and downstream kinases, which in turn alter the posttranslational modification and activation of ERs. Classical ERs and their splice variants reside at the membrane and mediate rapid effects cooperatively with G protein-coupled estrogen receptor 1 (GPER), G protein, and many other signaling molecules. GPER seems more effective in mediating the synthetic chemical-induced effects. There are also feedback and feedforward mechanisms between both pathways. Numerous factors may affect both pathways. Recently, some new layers of regulation on the estrogenic effects were identified. In this review, we summarize these multiple regulation layers and discuss the newly identified factors.

scholarly journals Hydroxylated Polybrominated Biphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein–Coupled Estrogen Receptor Mediated Pathways

2018 ◽  
Vol 126 (5) ◽  
pp. 057005 ◽  
Author(s):  
Lin-Ying Cao ◽  
Xiao-Min Ren ◽  
Yu Yang ◽  
Bin Wan ◽  
Liang-Hong Guo ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Estrogenic Effects ◽  
Polybrominated Biphenyl ◽  
G Protein Coupled
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