Effects of Personal Short-Term Exposure to Ambient Ozone on Blood Pressure and Vascular Endothelial Function: A Mechanistic Study Based on DNA Methylation and Metabolomics

2018 ◽  
Vol 52 (21) ◽  
pp. 12774-12782 ◽  
Author(s):  
Yongjie Xia ◽  
Yue Niu ◽  
Jing Cai ◽  
Zhijing Lin ◽  
Cong Liu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dna Methylation ◽  
Endothelial Function ◽  
Mechanistic Study ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Short Term ◽  
Ambient Ozone ◽  
Short Term Exposure

scholarly journals Effect of Strawberry Intake for 4 Weeks on Vascular Endothelial Function and Blood Pressure in Adults with Moderate Hypercholesterolemia (P06-128-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Di Xiao ◽  
Leailin Huang Huang ◽  
Indika Edirisinghe ◽  
Britt Burton-Freeman
Keyword(s):  
Blood Pressure ◽  
Endothelial Function ◽  
Vascular Function ◽  
Daily Intake ◽  
Random Order ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Freeze Dried ◽  
Pressure Independent ◽  
Hs Crp

Abstract Objectives The aim of this study is to investigate the effect of chronic strawberry intake on cardiovascular risk factors including fasting lipids concentrations, vascular endothelial function and blood pressure in middle-age overweight or obese individuals with moderate hypercholesterolemia. We hypothesized that 4-week strawberry intake would improve the lipids profile and concomitantly improve measures of vascular function. Methods In this randomized, double-blinded, controlled, crossover trial, thirty-four subjects (age 53 ± 1 years, BMI 31 ± 1 kg m-2, mean ± SD) consumed a strawberry beverage containing 25 gram freeze-dried strawberry powder or energy-matched control beverage in random order twice a day for 4 weeks. Treatment periods were separated by 4-week washout period. Fasting lipids, glucose, insulin, high sensitive c-reactive protein (hs-CRP), and postprandial flow-mediated dilation (FMD) and blood pressure, were measured at weeks 0, 4, 8 and 12. Results Fasting lipids, glucose, insulin, and hs-CRP did not differ between strawberry and control beverage interventions. In contrast, vascular function as measured by change in %FMD was significantly increased after strawberry compared to control after 4 weeks supplementation (4.3 ± 0.3% versus 3.6 ± 0.3%, respectively, p = 0.0096). In addition, %FMD was acutely increased from 0 to 1 hour after consuming strawberry beverage (p < 0.0001), which was consistent with reduced meal-induced increases in systolic blood pressure (SBP) postmeal (mean 2 hour changes in SBP after strawberry compared to control beverage, 2.3 ± 0.4 versus 3.4 ± 0.4 mmHg, p = 0.048). Conclusions Daily intake of strawberries may improve endothelial function and acute changes in blood pressure, independent of other metabolic changes, and may be considered a specific food/fruit to include in a heart-healthy diet in overweight or obese subjects with moderate hypercholesterolemia. Funding Sources California Strawberry Commission, Watsonville, CA, USA. Supporting Tables, Images and/or Graphs

scholarly journals Short‐term AMPK activation improves vascular endothelial function in old mice by a different mechanism than habitual aerobic exercise

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Brooke R Lawson ◽  
Douglas R Seals ◽  
Katherine A Magerko ◽  
Jessica R Durrant ◽  
Melanie L Zigler ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Aerobic Exercise ◽  
Vascular Endothelial ◽  
Ampk Activation ◽  
Vascular Endothelial Function ◽  
Short Term ◽  
Old Mice

scholarly journals Vascular Endothelial Function and Blood Pressure Homeostasis in Mice Overexpressing IGF Binding Protein-1

Diabetes ◽  
2003 ◽  
Vol 52 (8) ◽  
pp. 2075-2082 ◽  
Author(s):  
S. B. Wheatcroft ◽  
M. T. Kearney ◽  
A. M. Shah ◽  
D. J. Grieve ◽  
I. L. Williams ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Function ◽  
Binding Protein ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Blood Pressure Homeostasis ◽  
Igf Binding ◽  
Igf Binding Protein

Evaluation of the Associations between Vascular Endothelial Function and Coronary Artery Stenosis in Patients with Elevated Blood Pressure during Coronary Angiography

2014 ◽  
Vol 17 (3) ◽  
pp. 150 ◽  
Author(s):  
Ruijin Yang ◽  
Jun Yu
Keyword(s):  
Blood Pressure ◽  
Coronary Artery ◽  
Endothelial Function ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Elevated Blood Pressure ◽  
Control Group ◽  
Vascular Endothelial ◽  
Elevated Blood ◽  
Vascular Endothelial Function

<p><b>Objectives:</b> The aim of the present study is to explore the correlation between vascular endothelial function and coronary artery stenosis in non-hypertensive patients with elevated blood pressure under stress.</p><p><b>Methods:</b> This study included 1141 patients suspected of having coronary artery disease (CAD) without hypertension. Coronary arteriography and ultrasonic detection were used to measure the flow-mediated dilatation (FMD) function in the brachial artery. Patients were divided into 2 groups according to coronary angiography: experiment group, patients with blood pressure ? 140/90 mm Hg; control group, patients with blood pressure <140/90 mm Hg. The correlation between vascular endothelial function and coronary artery stenosis was observed.</p><p><b>Results:</b> The majority of the patients in the control group were found to have either normal coronary arteries or stenosis <50%. Patients in the experiment group (those with invasive blood pressure [IBP] >140/90) were more likely to have some degree of coronary artery stenosis. Specifically, there were significantly more patients with >50% stenosis in the experiment when compared with the control group (<i>P</i> < .05). The FMD in the experiment group was significantly lower than that in the control group (<i>P</i> < .05).</p><p><b>Conclusion:</b> The non-hypertensive patients with elevated blood pressure under stress had coronary artery stenosis, which was associated with vascular endothelial dysfunction.</p>

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