scholarly journals Short‐term AMPK activation improves vascular endothelial function in old mice by a different mechanism than habitual aerobic exercise

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Brooke R Lawson ◽  
Douglas R Seals ◽  
Katherine A Magerko ◽  
Jessica R Durrant ◽  
Melanie L Zigler ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Aerobic Exercise ◽  
Vascular Endothelial ◽  
Ampk Activation ◽  
Vascular Endothelial Function ◽  
Short Term ◽  
Old Mice

scholarly journals Sodium nitrite treatment restores vascular endothelial function in old mice with CKD

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Amy L Sindler ◽  
Melanie C Zigler ◽  
Mutsuko Yoshizawa ◽  
Chris Baylis ◽  
Douglas R Seals
Keyword(s):  
Endothelial Function ◽  
Sodium Nitrite ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Old Mice

scholarly journals Three Months Of Aerobic Exercise Training Improves Vascular Endothelial Function In Overweight/obese Older Adults

2020 ◽  
Vol 52 (7S) ◽  
pp. 739-739
Author(s):  
Kevin D. Ballard ◽  
Gabrielle Volk ◽  
Alexandra Hopun ◽  
Olivia Henderson ◽  
Kyle L. Timmerman
Keyword(s):  
Older Adults ◽  
Exercise Training ◽  
Endothelial Function ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function

Aerobic exercise offsets endothelial dysfunction induced by repetitive consumption of sugar-sweetened beverages in young healthy men

2020 ◽  
Vol 319 (1) ◽  
pp. R11-R18
Author(s):  
Joshua M. Bock ◽  
Erika Iwamoto ◽  
Jeffrey G. Horak ◽  
Andrew J. Feider ◽  
Satoshi Hanada ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Aerobic Exercise ◽  
Fasting Glucose ◽  
Area Under The Curve ◽  
Moderate Intensity ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Sugar Sweetened Beverage ◽  
Beneficial Effects

Consumption of a single, sugar-sweetened beverage (SSB) impairs vascular endothelial function. Regular aerobic exercise improves endothelium-dependent vasodilation; however, it is unknown whether these beneficial effects persist with frequent SSB consumption. Therefore, the purpose of this study was twofold; we studied the effects of repetitive SSB consumption (75 g d-glucose, 3 times/day) for 1 wk (Glu, n = 13, 23 ± 4 yr, 23.5 ± 3.4 kg/m2) on endothelium-dependent vasodilation (FMD). Then, in a separate cohort, we investigated whether 45 min of moderate-intensity aerobic exercise on five separate days offset the hypothesized decrease in FMD during the Glu protocol (Glu+Ex, n = 11, 21 ± 3 yr, 23.8 ± 2.4 kg/m2). Baseline, fasting [glucose] ( P = 0.15), [insulin] ( P = 0.25), %FMD ( P = 0.48), absolute FMD ( P = 0.66), and shear rate area under the curve (SRAUC; P = 0.82) were similar between groups. Following the interventions, fasting [glucose] (Glu: 94 ± 6 to 92 ± 6 mg/dL, Glu+Ex: 89 ± 8 to 87 ± 6 mg/dL, P = 0.74) and [insulin] (Glu: 11.3 ± 6.2 to 11.8 ± 8.9 μU/mL, Glu+Ex: 8.7 ± 2.9 to 9.4 ± 3.2 μU/mL, P = 0.89) were unchanged. %FMD was reduced in Glu (6.1 ± 2.2 to 5.1 ± 1.3%) and increased in Glu+Ex (6.6 ± 2.2 to 7.8 ± 2.4%, P < 0.05 for both). SRAUC increased similarly in both Glu [17,715 ± 8,275 to 22,922 ± 4,808 arbitrary units (A.U.)] and Glu+Ex (18,216 ± 4,516 to 21,666 ± 5,392 A.U., main effect of time P < 0.05). When %FMD was adjusted for SRAUC, attenuation was observed in Glu (0.41 ± 0.18 to 0.23 ± 0.08%/s × 103, P < 0.05) but not Glu+Ex (0.38 ± 0.14 to 0.38 ± 0.13%/s × 103, P = 0.88). Despite unchanged fasting [glucose] and [insulin], repeated consumption of SSBs impaired conduit artery vascular endothelial function. Additionally, subjects who engaged in regular moderate-intensity aerobic exercise did not demonstrate the same SSB-induced endothelial dysfunction. Collectively, these data suggest aerobic exercise may offset the deleterious effects of repetitive SSB consumption.

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