Solubility Determination and Thermodynamic Modeling of Glutaric Anhydride in Diverse Solvent Systems Consisting of Acetic Acid, Ethanoic Anhydride, and Tetrachloromethane from T = (278.45 to 324.45) K

A library of some novel classes of pyrano[2,3-c]pyrazole-3-carboxylates was synthesized by employing uncatalyzed domino four-component reaction using diethyloxaloacetate, hydrazine hydrate, aldehydes and malononitrile in refluxing of ethanol-acetic acid solvent systems. Series of domino reactions involving of pyrazolone formation, Michael addition, and Thorpe-Ziegler cyclization reaction managed to produce the cyclized products from moderate to excellent yield. This protocol provides a reliable, general and salient procedure for the title compound using a one-pot approach. Preliminary biological screening unveiled limited potentials of this class of compounds for antimicrobial lead compound due to its limited solubility properties.

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A modified Solvay process with low‐temperature calcination of NaHCO 3 using monoethanolamine: Solubility determination and thermodynamic modeling

AIChE Journal ◽

10.1002/aic.16701 ◽

2019 ◽

Vol 65 (10) ◽

Cited By ~ 5

Author(s):

Qiaoxin Wang ◽

Zhibao Li

Keyword(s):

Low Temperature ◽

Thermodynamic Modeling ◽

Solvay Process ◽

Solubility Determination

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Solubility determination and thermodynamic modeling of solid−liquid equilibria in the LiBO2−Li2B4O7−H2O system at 298.15 K and 323.15 K

Fluid Phase Equilibria ◽

10.1016/j.fluid.2020.112783 ◽

2020 ◽

Vol 523 ◽

pp. 112783 ◽

Cited By ~ 1

Author(s):

Lan Yang ◽

Lele Chen ◽

Tao Zhang ◽

Dan Li ◽

Lingzong Meng ◽

...

Keyword(s):

Thermodynamic Modeling ◽

Solubility Determination ◽

Solid Liquid

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Liquid Chromatographic Determination of Phenolic Impurities in Technical MCPA Using Electrochemical Detection (Coulometric Mode)

Journal of AOAC INTERNATIONAL ◽

10.1093/jaoac/71.2.325 ◽

1988 ◽

Vol 71 (2) ◽

pp. 325-327

Author(s):

Yuk Y Wigfield ◽

Monique Lanouette

Keyword(s):

Acetic Acid ◽

Flow Rate ◽

Chromatographic Determination ◽

Gradient System ◽

Mobile Phases ◽

Liquid Chromatographic Determination ◽

Phase Liquid ◽

Solvent Systems ◽

Liquid Chromatographic

Abstract Fifteen samples of technical 4-chloro-2-methylphenoxy acetic acid (MCPA) from 6 manufacturers were analyzed for the presence of 13 different phenolic impurities. Reverse-phase liquid chromatography with an electrochemical (coulometric mode) detector was used for qualitative and quantitative determinations. The phenols were separated using a 40-70% methanol and 60-30% 0.02M KH2P04 (pH 4.0) 35 min gradient system on a Spheri-5-RP-18 column. Confirmation of the phenols present was done by retention time comparison with the corresponding standards, using 2 other isocratic mobile phases, methanol-0.2M acetic acid (60 + 40) at a flow rate of 1.3 mL/min and acetonitrile-0.02M KH2P04 (45 + 55) (pH 3.0) at a flow rate of 0.90 mL/min. The similarity of results on 3 different solvent systems demonstrates the absence of any interfering responses. 2-Methyl-4-chlorophenol (average 0.168%) and 2-methyl- 4,6-dichlorophenol (average 0.004%) were detected in all 15 samples. 3-Methylphenol (0.002%) and 2,6-dimethyl-4-chlorophenol (0.002%) were detected in one sample only. The minimum detectable amount ranged from 0.1 to 0.6 ng, depending on the phenol. This corresponds to less than 0.002% when expressed relative to the weight of sample. The coefficient of variation for multiple analyses of the same sample (n = 6) is 1% for 2-methyl-4-chlorophenol and 3% for 2-methy 1-4,6- dichlorophenol.

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