Carbon Monoxide Inhibits Cytochrome P450 Enzymes CYP3A4/2C8 in Human Breast Cancer Cells, Increasing Sensitivity to Paclitaxel

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00404 ◽

2021 ◽

Author(s):

Brian Kawahara ◽

Kym F. Faull ◽

Carla Janzen ◽

Pradip K. Mascharak

Keyword(s):

Breast Cancer ◽

Carbon Monoxide ◽

Cytochrome P450 ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Cytochrome P450 Enzymes

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Overcoming chemotherapeutic resistance; inhibition of cytochrome P450-mediated metabolism of paclitaxel in human breast cancer cells in situ with carbon monoxide

10.1021/scimeetings.0c00313 ◽

2020 ◽

Author(s):

Pradip Mascharak ◽

Brian Kawahara

Keyword(s):

Breast Cancer ◽

Carbon Monoxide ◽

Cytochrome P450 ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Chemotherapeutic Resistance

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ACTIVATION OF THIO-TEPA CYTOTOXICITY TOWARD HUMAN BREAST-CANCER CELLS BY HEPATIC CYTOCHROME-P450

International Journal of Oncology ◽

10.3892/ijo.2.5.731 ◽

1993 ◽

Author(s):

SF NG ◽

DJ WAXMAN

Keyword(s):

Breast Cancer ◽

Cytochrome P450 ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Hepatic Cytochrome

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Highly specific cytochrome P450-like enzymes for all-trans-retinoic acid in T47D human breast cancer cells

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.81.6.2069 ◽

1996 ◽

Vol 81 (6) ◽

pp. 2069-2075 ◽

Author(s):

I. S. Han

Keyword(s):

Breast Cancer ◽

Cytochrome P450 ◽

Retinoic Acid ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Trans Retinoic Acid ◽

All Trans Retinoic Acid

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Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non-ortho-substituted polychlorinated biphenyls

Toxicology in Vitro ◽

10.1016/s0887-2333(02)00091-7 ◽

2002 ◽

Vol 16 (6) ◽

pp. 695-704 ◽

Author(s):

B.C Spink ◽

S Pang ◽

B.T Pentecost ◽

D.C Spink

Keyword(s):

Breast Cancer ◽

Cytochrome P450 ◽

Polychlorinated Biphenyls ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Cytochrome P450 1B1

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Highly specific cytochrome P450-like enzymes for all-trans-retinoic acid in T47D human breast cancer cells.

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.81.6.8964830 ◽

1996 ◽

Vol 81 (6) ◽

pp. 2069-2075

Author(s):

I S Han ◽

J H Choi

Keyword(s):

Breast Cancer ◽

Cytochrome P450 ◽

Retinoic Acid ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Trans Retinoic Acid ◽

All Trans Retinoic Acid

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Attenuation of Antioxidant Capacity in Human Breast Cancer Cells by Carbon Monoxide through Inhibition of Cystathionine β-Synthase Activity: Implications in Chemotherapeutic Drug Sensitivity

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00476 ◽

2017 ◽

Vol 60 (19) ◽

pp. 8000-8010 ◽

Author(s):

Brian Kawahara ◽

Travis Moller ◽

Kayla Hu-Moore ◽

Samantha Carrington ◽

Kym F. Faull ◽

...

Keyword(s):

Breast Cancer ◽

Carbon Monoxide ◽

Antioxidant Capacity ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Drug Sensitivity ◽

Chemotherapeutic Drug ◽

Human Breast Cancer Cells ◽

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Antiproliferative and apoptotic activities of extracts from carob tree (Ceratonia siliqua L.) in MDA-MB-231 human breast cancer cells

Planta Medica ◽

10.1055/s-0028-1084046 ◽

2008 ◽

Vol 74 (09) ◽

Author(s):

L Custódio ◽

E Fernandes ◽

AL Escapa ◽

S López-Avilés ◽

A Fajardo ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Ceratonia Siliqua ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Ceratonia Siliqua L

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Combination Treatment of Human Breast Cancer Cells with Possible RNAi Enhancer and siRNA Targeting Polo-Like Kinase 1

10.26226/morressier.57d6b2b8d462b8028d88d8f0 ◽

2016 ◽

Author(s):

Masahiro Hashimoto

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Combination Treatment ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

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Targeting Human Breast Cancer Cells that Overexpress HER-2/neu mRNA by an Antisense Iron Responsive Element

10.21236/ada390720 ◽

2000 ◽

Author(s):

Duen-Hwa Yan

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Iron Responsive Element ◽

Her 2 ◽

Responsive Element

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Targeting Human Breast Cancer Cells that Overexpress HER-2/neu mRNA by an Antisense Iron Responsive Element

10.21236/ada395672 ◽

2001 ◽

Author(s):

Duen-Hwa Yan

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Iron Responsive Element ◽

Her 2 ◽

Responsive Element

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