Subphthalocyanines as Efficient Photosensitizers with Nanomolar Photodynamic Activity against Cancer Cells

2021 ◽  
Author(s):  
Jiri Demuth ◽  
Lucia Gallego ◽  
Magdalena Kozlikova ◽  
Miloslav Machacek ◽  
Radim Kucera ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photodynamic Activity

Diazepinoporphyrazines Containing Peripheral Styryl Substituents and Their Promising Nanomolar Photodynamic Activity against Oral Cancer Cells in Liposomal Formulations

ChemMedChem ◽  
2014 ◽  
pp. n/a-n/a
Author(s):  
Jaroslaw Piskorz ◽  
Krystyna Konopka ◽  
Nejat Düzgüneş ◽  
Zofia Gdaniec ◽  
Jadwiga Mielcarek ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Liposomal Formulations ◽  
Photodynamic Activity ◽  
Oral Cancer Cells

scholarly journals Hypericin photodynamic activity in DPPC liposomes – part II: stability and application in melanoma B16-F10 cancer cells

2020 ◽  
Vol 19 (5) ◽  
pp. 620-630 ◽  
Author(s):  
Flávia Amanda Pedroso de Morais ◽  
Renato Sonchini Gonçalves ◽  
Bruno Henrique Vilsinski ◽  
Danielle Lazarin-Bidóia ◽  
Rodolfo Bento Balbinot ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photodynamic Effect ◽  
Melanoma B16 ◽  
Photodynamic Activity

The Hyp/DPPC formulation photodynamic effect in melanoma B16-F10 cells pointed out its potentiality for PDT against cancer cells.

Nanoassembly of an amphiphilic cyclodextrin and Zn(ii)-phthalocyanine with the potential for photodynamic therapy of cancer

RSC Advances ◽  
2014 ◽  
Vol 4 (83) ◽  
pp. 43903-43911 ◽  
Author(s):  
Claudia Conte ◽  
Angela Scala ◽  
Gabriel Siracusano ◽  
Nancy Leone ◽  
Salvatore Patanè ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Photodynamic Therapy Of Cancer ◽  
Photodynamic Activity ◽  
Highly Hydrophobic ◽  
Amphiphilic Cyclodextrin

A photosensitising nanoassembly from non-ionic amphiphilic cyclodextrin and highly hydrophobic Zn-pthalocyanine with the capability to sustain the release of photosensitiser and showing photodynamic activity in cancer cells.

Synthesis and photodynamic activities of a new metronidazole-appended porphyrin and its Zn(II) complex

2015 ◽  
Vol 19 (10) ◽  
pp. 1107-1113 ◽  
Author(s):  
Qiong Yu ◽  
Wei-Xia Xu ◽  
Ya-Hong Yao ◽  
Zeng-Qi Zhang ◽  
Shu Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Crystal Structure ◽  
Oxygen Atom ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Porphyrin Ring ◽  
H Nmr ◽  
Pyramidal Geometry ◽  
Photodynamic Activity ◽  
Square Pyramidal Geometry

One novel porphyrin 5,10,15-tris(phenyl)-20-[4-(2-(2-methyl-5-nitro-imidazolyl)ethoxyl)phenyl] porphyrin and its zinc(II) metalloporphyrin were synthesized and characterized by IR, UV-vis, 1H NMR, MS and elemental analysis. The single crystal structure of zinc(II) porphyrin shows that the Zn(II) ion is coordinated with four nitrogen atoms of porphyrin ring and one oxygen atom of ethanol from axial, forming a five-coordinated square pyramidal geometry. Their cytotoxicity and photodynamic activity against breast cancer cells were studied. The results indicate that both of the porphyrins display high phototoxicity to the breast cancer cells with the negligible dark toxicity. In addition, the photodynamic activity of zinc(II) porphyrin was obviously higher than that of the free porphyrin.

scholarly journals Efficient Synthesis and Photodynamic Activity of Porphyrin-Saccharide Conjugates:  Targeting and Incapacitating Cancer Cells†

Biochemistry ◽  
2004 ◽  
Vol 43 (34) ◽  
pp. 10918-10929 ◽  
Author(s):  
Xin Chen ◽  
Li Hui ◽  
David A. Foster ◽  
Charles Michael Drain
Keyword(s):  
Cancer Cells ◽  
Efficient Synthesis ◽  
Photodynamic Activity

Sulfanyl porphyrazines: Molecular barrel-like self-assembly in crystals, optical properties and in vitro photodynamic activity towards cancer cells

2017 ◽  
Vol 136 ◽  
pp. 898-908 ◽  
Author(s):  
Jaroslaw Piskorz ◽  
Sebastian Lijewski ◽  
Mateusz Gierszewski ◽  
Karolina Gorniak ◽  
Lukasz Sobotta ◽  
...  
Keyword(s):  
Optical Properties ◽  
Cancer Cells ◽  
Self Assembly ◽  
Photodynamic Activity

scholarly journals Photodynamic activity of Sn(IV) meso-tetraacenaphthylporphyrin and its methyl-β-cyclodextrin inclusion complexes on MCF-7 breast cancer cells

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1486-1494
Author(s):  
Nthabeleng Molupe ◽  
Balaji Babu ◽  
Earl Prinsloo ◽  
Abdessamad Y. A. Kaassis ◽  
Katharina Edkins ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Water Solubility ◽  
Therapeutic Window ◽  
Cyclodextrin Inclusion Complexes ◽  
Cyclodextrin Inclusion ◽  
Yield Value ◽  
Photodynamic Activity ◽  
Mcf 7

A novel Sn(IV) meso-tetraacenaphthylporphyrin (SnTAcP) has been synthesized and characterized. SnTAcP was complexed with methyl-[Formula: see text]-cyclodextrin (m[Formula: see text]-CD), a nanocarrier that enhances water solubility, and the complexes were evaluated as PDT agents using MCF-7 breast cancer cells. A relatively low singlet oxygen quantum yield value of 0.36 was obtained in DMF, and the lowest energy Q band lies at 608 nm on the edge of the therapeutic window. SnTAcP was found to be non-toxic in the dark and phototoxic towards MCF-7 breast cancer cells with a half-maximal inhibitory concentration (IC[Formula: see text] value of 11 ± 1.1 [Formula: see text]g · mL[Formula: see text] after 30 min of irradiation with a 625 nm Thorlabs LED that provides a dose of 432 J · cm[Formula: see text]. A higher IC[Formula: see text] value of 21 ± 1.1 [Formula: see text]g · mL-1 was obtained for the m[Formula: see text]-CD inclusion complex of SnTAcP.

Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis

2010 ◽  
Vol 648 (1-3) ◽  
pp. 50-58 ◽  
Author(s):  
Hong-Zin Lee ◽  
Wen-Hui Yang ◽  
Mann-Jen Hour ◽  
Chi-Yu Wu ◽  
Wen-Huang Peng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Photodynamic Activity ◽  
Aloe Emodin

Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(iii) complexes

2017 ◽  
Vol 53 (12) ◽  
pp. 2052-2055 ◽  
Author(s):  
Jiangping Liu ◽  
Chengzhi Jin ◽  
Bo Yuan ◽  
Xingguo Liu ◽  
Yu Chen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Multicellular Tumor Spheroids ◽  
Tumor Spheroids ◽  
Photon Irradiation ◽  
Two Photon ◽  
Photodynamic Activity

Three AIE-active Ir(iii) complexes that preferentially accumulate in the mitochondria of cancer cells through endocytosis were manifested in a lit up photodynamic activity in mitochondria with efficient lethality towards cancer cells and multicellular tumor spheroids under two-photon irradiation.

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