CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

Corena V. Grant; Shengxin Cai; April L. Risinger; Huiyun Liang; Barry R. O’Keefe; John G. Doench; Robert H. Cichewicz; Susan L. Mooberry

doi:10.1021/acs.jnatprod.0c00642

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

Journal of Natural Products ◽

10.1021/acs.jnatprod.0c00642 ◽

2020 ◽

Vol 83 (10) ◽

pp. 3080-3092

Author(s):

Corena V. Grant ◽

Shengxin Cai ◽

April L. Risinger ◽

Huiyun Liang ◽

Barry R. O’Keefe ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Genome Wide ◽

Selective Activity

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A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells

Cancer Cell ◽

10.1016/j.ccr.2013.07.008 ◽

2013 ◽

Vol 24 (2) ◽

pp. 182-196 ◽

Cited By ~ 99

Author(s):

Fabio Petrocca ◽

Gabriel Altschuler ◽

Shen Mynn Tan ◽

Marc L. Mendillo ◽

Haoheng Yan ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Sirna Screen ◽

Genome Wide ◽

A Genome

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Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Journal of Cellular Physiology ◽

10.1002/jcp.26634 ◽

2018 ◽

Vol 233 (10) ◽

pp. 7113-7127 ◽

Cited By ~ 15

Author(s):

Varun Maturi ◽

Stefan Enroth ◽

Carl-Henrik Heldin ◽

Aristidis Moustakas

Keyword(s):

Breast Cancer ◽

Transcription Factor ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Genome Wide

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Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant

PLoS ONE ◽

10.1371/journal.pone.0172832 ◽

2017 ◽

Vol 12 (2) ◽

pp. e0172832 ◽

Cited By ~ 13

Author(s):

Marisa Simon ◽

Fahmi Mesmar ◽

Luisa Helguero ◽

Cecilia Williams

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Genome Wide ◽

Context Dependent

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Faculty Opinions recommendation of Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737060005.793568589 ◽

2019 ◽

Author(s):

Junjie Chen

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative

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MiRNAs-181a/b as Predictive biomarkers for olaparib sensitivity in triple-negative breast cancer cells.

Biochemistry Letters ◽

10.21608/blj.2017.47612 ◽

2017 ◽

Vol 12 (1) ◽

pp. 221-229

Author(s):

Abeer M. Ashmawy ◽

Mona A. Sheta ◽

Faten Zahran ◽

Abdel Hady A. Abdel Wahab

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Predictive Biomarkers

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microRNA-506-3p suppresses the proliferation of triple negative breast cancer cells via targeting SNAI2

Molecular & Cellular Toxicology ◽

10.1007/s13273-021-00160-7 ◽

2021 ◽

Vol 17 (4) ◽

pp. 513-522

Author(s):

Xuye Zhao ◽

Xiangdong Bai ◽

Weina Li ◽

Xuezhen Gao ◽

Xiaoli Wang ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative

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Fluorouracil uptake in triple‐negative breast cancer cells: Negligible contribution of equilibrative nucleoside transporters 1 and 2

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2261 ◽

2021 ◽

Author(s):

Saki Noguchi ◽

Akinori Takagi ◽

Takahiro Tanaka ◽

Yu Takahashi ◽

Xiaole Pan ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Nucleoside Transporters ◽

Equilibrative Nucleoside Transporters ◽

Negligible Contribution

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Combinatorial targeting of microRNA-26b and microRNA-101 exerts a synergistic inhibition on cyclooxygenase-2 in brain metastatic triple-negative breast cancer cells

Breast Cancer Research and Treatment ◽

10.1007/s10549-021-06255-y ◽

2021 ◽

Author(s):

Rania Harati ◽

Aloïse Mabondzo ◽

Abdelaziz Tlili ◽

Ghalia Khoder ◽

Mona Mahfood ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Cyclooxygenase 2 ◽

Synergistic Inhibition

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Preferential uptake of antibody targeted calcium phosphosilicate nanoparticles by metastatic triple negative breast cancer cells in co-cultures of human metastatic breast cancer cells plus bone osteoblasts

Nanomedicine Nanotechnology Biology and Medicine ◽

10.1016/j.nano.2021.102383 ◽

2021 ◽

Vol 34 ◽

pp. 102383

Author(s):

Karen M. Bussard ◽

Christopher M. Gigliotti ◽

Bernadette M. Adair ◽

Jenna M. Snyder ◽

Nicholas T. Gigliotti ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Metastatic Breast ◽

Calcium Phosphosilicate ◽

Preferential Uptake

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MicroRNA-543 inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of triple-negative breast cancer cells via down-regulation of ACTL6A gene

Clinical & Translational Oncology ◽

10.1007/s12094-021-02672-z ◽

2021 ◽

Author(s):

Y. L. Wang ◽

R. H. Liang ◽

C. Y. Wang ◽

R. P. Zhang ◽

S. Y. Wu ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Triple Negative Breast Cancer ◽

Breast Cancer Cells ◽

Triple Negative ◽

Epithelial Mesenchymal Transition ◽

Down Regulation ◽

Mesenchymal Transition

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