Lincolnenins A–D: Isomeric Bactericidal Bianthracenes from Streptomyces lincolnensis

2020 ◽  
Author(s):  
Osama G. Mohamed ◽  
Zeinab G. Khalil ◽  
Angela A. Salim ◽  
Hui Cui ◽  
Antje Blumenthal ◽  
...  
Keyword(s):  
Streptomyces Lincolnensis

scholarly journals TRANS-3-(METHYLTHIO)- ACRYLIC ACID, A NEW METABOLIC PRODUCT FROM STREPTOMYCES LINCOLNENSIS

1969 ◽  
Vol 22 (10) ◽  
pp. 510-510 ◽  
Author(s):  
J. VISSER ◽  
H. F. MEYER
Keyword(s):  
Acrylic Acid ◽  
Metabolic Product ◽  
Streptomyces Lincolnensis

scholarly journals LmbU directly regulates SLINC_RS02575, SLINC_RS05540 and SLINC_RS42780, which are located outside the lmb cluster and inhibit lincomycin biosynthesis in Streptomyces lincolnensis

2021 ◽  
Author(s):  
Bingbing Hou ◽  
Xianyan Zhang ◽  
Yue Mao ◽  
Ruida Wang ◽  
Jiang Ye ◽  
...  
Keyword(s):  
Binding Sites ◽  
Biosynthetic Gene Cluster ◽  
Regulatory Mechanisms ◽  
Whole Genome ◽  
Biosynthetic Gene ◽  
Qrt Pcr ◽  
Dna Binding Sites ◽  
Reporter Assays ◽  
Streptomyces Lincolnensis

The productions of antibiotics are usually regulated by cluster-situated regulators (CSRs), which can directly regulate the genes within the corresponding biosynthetic gene cluster (BGC). However, few studies have looked into the regulation of CSRs on the targets outside the BGC. Here, we screened the targets of LmbU in the whole genome of S. lincolnensis, and found 14 candidate targets, among of which, 8 targets can bind to LmbU by EMSAs. Reporter assays in vivo revealed that LmbU repressed transcription of SLINC_RS02575 and SLINC_RS05540, while activated transcription of SLINC_RS42780. In addition, disruptions of SLINC_RS02575, SLINC_RS05540 and SLINC_RS42780 promoted the production of lincomycin, and qRT-PCR showed that SLINC_RS02575, SLINC_RS05540 and SLINC_RS42780 inhibited transcription of the lmb genes, indicating that all the three regulators can negatively regulate lincomycin biosynthesis. What's more, the homologues of LmbU and its targets SLINC_RS02575, SLINC_RS05540 and SLINC_RS42780 are widely found in actinomycetes, while the distributions of DNA-binding sites (DBS) of LmbU are diverse, indicating the regulatory mechanisms of LmbU homologues in various strains are different and complicated.

Antitumor and antioxidant activity of protocatechualdehyde produced from Streptomyces lincolnensis M-20

2008 ◽  
Vol 31 (12) ◽  
pp. 1572-1577 ◽  
Author(s):  
Kyoung-Ja Kim ◽  
Mi-Ae Kim ◽  
Jee-Hyung Jung
Keyword(s):  
Antioxidant Activity ◽  
Streptomyces Lincolnensis

Lincomycin

1964 ◽  
Vol 2 (25) ◽  
pp. 99-99
Keyword(s):  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Streptomyces Lincolnensis

Lincomycin (Lincocin - Upjohn; Mycivin - Boots) is a new antibiotic with activity against Gram-positive bacteria. It was isolated by Upjohn in 1955 from Streptomyces lincolnensis. It is supplied as the hydrochloride, which is soluble in water.

Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11

1995 ◽  
Vol 16 (6) ◽  
pp. 1137-1156 ◽  
Author(s):  
Ursula Peschke ◽  
Heike Schmidt ◽  
Hui-Zhan Zhang ◽  
Wolfgang Piepersberg
Keyword(s):  
Gene Cluster ◽  
Molecular Characterization ◽  
Streptomyces Lincolnensis

scholarly journals AdpAlin, a Pleiotropic Transcriptional Regulator, Is Involved in the Cascade Regulation of Lincomycin Biosynthesis in Streptomyces lincolnensis

2019 ◽  
Vol 10 ◽  
Author(s):  
Yajing Kang ◽  
Yingying Wang ◽  
Bingbing Hou ◽  
Ruida Wang ◽  
Jiang Ye ◽  
...  
Keyword(s):  
Transcriptional Regulator ◽  
Streptomyces Lincolnensis

scholarly journals Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis

2015 ◽  
Vol 119 (4) ◽  
pp. 1064-1074 ◽  
Author(s):  
A.-P. Pang ◽  
L. Du ◽  
C.-Y. Lin ◽  
J. Qiao ◽  
G.-R. Zhao
Keyword(s):  
Industrial Strain ◽  
Streptomyces Lincolnensis

scholarly journals Effect of Interaction between Protocatechualdehyde Produced from Streptomyces lincolnensis M-20 and Copper Ions on Antioxidant and Pro-oxidant Activities

2014 ◽  
Vol 50 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Kyoung-Ja Kim ◽  
Jae-Hun Lee ◽  
Yong-Joon Yang
Keyword(s):  
Copper Ions ◽  
Streptomyces Lincolnensis

Isolation, Structure Elucidation, and Biosynthesis of a Cysteate-Containing Nonribosomal Peptide in Streptomyces lincolnensis

2018 ◽  
Vol 83 (13) ◽  
pp. 7102-7108 ◽  
Author(s):  
Min Wang ◽  
Dandan Chen ◽  
Qunfei Zhao ◽  
Wen Liu
Keyword(s):  
Structure Elucidation ◽  
Nonribosomal Peptide ◽  
Streptomyces Lincolnensis

scholarly journals Degradation Properties of Melamine Wastewater with Streptomyces lincolnensis

2014 ◽  
Vol 26 (16) ◽  
pp. 5203-5206
Author(s):  
Yong Xie ◽  
Bao-Zhong Zhou ◽  
Xing-Hui Rao ◽  
Yun-Sheng ◽  
Hong-Yan Wang
Keyword(s):  
Streptomyces Lincolnensis ◽  
Degradation Properties
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