scholarly journals Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis

2015 ◽  
Vol 119 (4) ◽  
pp. 1064-1074 ◽  
Author(s):  
A.-P. Pang ◽  
L. Du ◽  
C.-Y. Lin ◽  
J. Qiao ◽  
G.-R. Zhao
Keyword(s):  
Industrial Strain ◽  
Streptomyces Lincolnensis

scholarly journals TRANS-3-(METHYLTHIO)- ACRYLIC ACID, A NEW METABOLIC PRODUCT FROM STREPTOMYCES LINCOLNENSIS

1969 ◽  
Vol 22 (10) ◽  
pp. 510-510 ◽  
Author(s):  
J. VISSER ◽  
H. F. MEYER
Keyword(s):  
Acrylic Acid ◽  
Metabolic Product ◽  
Streptomyces Lincolnensis

scholarly journals Complete Genome Sequence of Brevibacterium linens SMQ-1335

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Alessandra G. de Melo ◽  
Simon J. Labrie ◽  
Jeannot Dumaresq ◽  
Richard J. Roberts ◽  
Denise M. Tremblay ◽  
...  
Keyword(s):  
Complete Genome Sequence ◽  
Open Reading Frames ◽  
Type I ◽  
Industrial Strain ◽  
Modification System ◽  
Brevibacterium Linens ◽  
Restriction Modification System ◽  
New Type ◽  
Restriction Modification ◽  
Reading Frames

Brevibacterium linens is one of the main bacteria found in the smear of surface-ripened cheeses. The genome of the industrial strain SMQ-1335 was sequenced using PacBio. It has 4,209,935 bp, a 62.6% G+C content, 3,848 open reading frames, and 61 structural RNAs. A new type I restriction-modification system was identified.

Reconstruction and analysis of the industrial strain Bacillus megaterium WSH002 genome-scale in silico metabolic model

2013 ◽  
Vol 164 (4) ◽  
pp. 503-509 ◽  
Author(s):  
Wei Zou ◽  
Maoda Zhou ◽  
Liming Liu ◽  
Jian Chen
Keyword(s):  
Bacillus Megaterium ◽  
In Silico ◽  
Metabolic Model ◽  
Industrial Strain ◽  
Genome Scale

scholarly journals Draft Genome Sequence of Saccharomyces cerevisiae Strain Awamori Number 101, Commonly Used to Make Awamori, a Traditional Spirit, in Okinawa, Japan

2021 ◽  
Vol 10 (25) ◽  
Author(s):  
Masatoshi Tsukahara ◽  
Kotaro Ise ◽  
Maiko Nezuo ◽  
Haruna Azuma ◽  
Takeshi Akao ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Next Generation Sequencing ◽  
Genome Sequence ◽  
Draft Genome ◽  
Draft Genome Sequence ◽  
Next Generation ◽  
Industrial Strain ◽  
Content Type ◽  
Short Reads ◽  
Generation Sequencing

We report here the draft genome sequence for Saccharomyces cerevisiae strain Awamori number 101, an industrial strain used for producing awamori, a distilled alcohol beverage. It was constructed by assembling the short reads obtained by next-generation sequencing. The 315 contigs constitute an 11.5-Mbp genome sequence coding 6,185 predicted proteins.

scholarly journals LmbU directly regulates SLINC_RS02575, SLINC_RS05540 and SLINC_RS42780, which are located outside the lmb cluster and inhibit lincomycin biosynthesis in Streptomyces lincolnensis

2021 ◽  
Author(s):  
Bingbing Hou ◽  
Xianyan Zhang ◽  
Yue Mao ◽  
Ruida Wang ◽  
Jiang Ye ◽  
...  
Keyword(s):  
Binding Sites ◽  
Biosynthetic Gene Cluster ◽  
Regulatory Mechanisms ◽  
Whole Genome ◽  
Biosynthetic Gene ◽  
Qrt Pcr ◽  
Dna Binding Sites ◽  
Reporter Assays ◽  
Streptomyces Lincolnensis

The productions of antibiotics are usually regulated by cluster-situated regulators (CSRs), which can directly regulate the genes within the corresponding biosynthetic gene cluster (BGC). However, few studies have looked into the regulation of CSRs on the targets outside the BGC. Here, we screened the targets of LmbU in the whole genome of S. lincolnensis, and found 14 candidate targets, among of which, 8 targets can bind to LmbU by EMSAs. Reporter assays in vivo revealed that LmbU repressed transcription of SLINC_RS02575 and SLINC_RS05540, while activated transcription of SLINC_RS42780. In addition, disruptions of SLINC_RS02575, SLINC_RS05540 and SLINC_RS42780 promoted the production of lincomycin, and qRT-PCR showed that SLINC_RS02575, SLINC_RS05540 and SLINC_RS42780 inhibited transcription of the lmb genes, indicating that all the three regulators can negatively regulate lincomycin biosynthesis. What's more, the homologues of LmbU and its targets SLINC_RS02575, SLINC_RS05540 and SLINC_RS42780 are widely found in actinomycetes, while the distributions of DNA-binding sites (DBS) of LmbU are diverse, indicating the regulatory mechanisms of LmbU homologues in various strains are different and complicated.

Antitumor and antioxidant activity of protocatechualdehyde produced from Streptomyces lincolnensis M-20

2008 ◽  
Vol 31 (12) ◽  
pp. 1572-1577 ◽  
Author(s):  
Kyoung-Ja Kim ◽  
Mi-Ae Kim ◽  
Jee-Hyung Jung
Keyword(s):  
Antioxidant Activity ◽  
Streptomyces Lincolnensis

Lincomycin

1964 ◽  
Vol 2 (25) ◽  
pp. 99-99
Keyword(s):  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Streptomyces Lincolnensis

Lincomycin (Lincocin - Upjohn; Mycivin - Boots) is a new antibiotic with activity against Gram-positive bacteria. It was isolated by Upjohn in 1955 from Streptomyces lincolnensis. It is supplied as the hydrochloride, which is soluble in water.

Sign in / Sign up

Export Citation Format

Share Document