Photoionization of Two Potential Biofuel Additives: γ-Valerolactone and Methyl Butyrate

2021 ◽  
Author(s):  
Andrea Giustini ◽  
Matthew Winfough ◽  
Joseph Czekner ◽  
Bálint Sztáray ◽  
Giovanni Meloni ◽  
...  
Keyword(s):  
Methyl Butyrate

scholarly journals The Leucine Catabolite and Dietary Supplement β-Hydroxy-β-Methyl Butyrate (HMB) as an Epigenetic Regulator in Muscle Progenitor Cells

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 512
Author(s):  
Virve Cavallucci ◽  
Giovambattista Pani
Keyword(s):  
Histone Acetylation ◽  
Dietary Supplement ◽  
Hdac Inhibitor ◽  
Muscle Wasting ◽  
C2c12 Cells ◽  
Myoblast Differentiation ◽  
Epigenetic Mark ◽  
Epigenetic Regulator ◽  
Methyl Butyrate

β-Hydroxy-β-Methyl Butyrate (HMB) is a natural catabolite of leucine deemed to play a role in amino acid signaling and the maintenance of lean muscle mass. Accordingly, HMB is used as a dietary supplement by sportsmen and has shown some clinical effectiveness in preventing muscle wasting in cancer and chronic lung disease, as well as in age-dependent sarcopenia. However, the molecular cascades underlying these beneficial effects are largely unknown. HMB bears a significant structural similarity with Butyrate and β-Hydroxybutyrate (βHB), two compounds recognized for important epigenetic and histone-marking activities in multiple cell types including muscle cells. We asked whether similar chromatin-modifying actions could be assigned to HMB as well. Exposure of murine C2C12 myoblasts to millimolar concentrations of HMB led to an increase in global histone acetylation, as monitored by anti-acetylated lysine immunoblotting, while preventing myotube differentiation. In these effects, HMB resembled, although with less potency, the histone deacetylase (HDAC) inhibitor Sodium Butyrate. However, initial studies did not confirm a direct inhibitory effect of HMB on HDACs in vitro. β-Hydroxybutyrate, a ketone body produced by the liver during starvation or intense exercise, has a modest effect on histone acetylation of C2C12 cells or in vitro HDAC inhibitor activities, and, unlike Butyrate and HMB, did not interfere with myotube formation in a myoblast differentiation assay. Instead, βHB dramatically increased lysine β-hydroxybutyrylation (Kbhb) of histone tails, an epigenetic mark associated with fasting responses and muscle catabolic states. However, when C2C12 cells were exposed to βHB in the presence of equimolar HMB this chromatin modification was drastically reduced, pointing to a role for HMB in attenuating ketosis-associated muscle wasting. In conclusion, while their mechanistic underpinnings remain to be clarified, these preliminary observations highlight novel and potentially important activities of HMB as an epigenetic regulator and βHB antagonist in muscle precursor cells, to be further explored in their biomedical implications.

The Flavor Property of Soft Cheese Fermented by Two Stains of Streptococcus thermophilus and Made of Reconstituted Milk

2011 ◽  
Vol 396-398 ◽  
pp. 1536-1540
Author(s):  
Yan Hua Li ◽  
Lan Wei Zhang ◽  
Wei Jun Wang ◽  
Li Li Zhang ◽  
Xue Han ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Butyl Acetate ◽  
Streptococcus Thermophilus ◽  
Acetate Methyl ◽  
Soft Cheese ◽  
Significant Difference ◽  
Cheese Volatiles ◽  
Methyl Butyrate ◽  
Reconstituted Milk ◽  
The Impact

The effect of reconstituted milk inoculation with Streptococcus thermophilus TM11 and Streptococcus thermophilus SP 1.1 on soft cheese volatiles was investigated. The impact flavors of 2,3-butanedione, 2,3-pentanedione, ethyl acetate, methyl butyrate, ethyl butyrate, butyl acetate and butyric acid were only detected in the fermented cheeses. Levels of diketones were higher in the cheeses fermented by mixed cultures than single culture, while levels of esters except ethyl acetate and butyl acetate showed an opposite tendency. There was significant difference in the levels of 2-hexenal and 2-nonenal among the cheeses. Other compounds originated from lipid oxidation, Strecker degradation, biosynthesis and forages were not significantly influenced by milk inoculation with Streptococcus thermophilus.

‘Gelozymes’ in organic synthesis. Part 2: Candida rugosa lipase mediated synthesis of enantiomerically pure (S)-cyano(3-phenoxyphenyl)methyl butyrate

2001 ◽  
Vol 12 (12) ◽  
pp. 1695-1699 ◽  
Author(s):  
Nitin W. Fadnavis ◽  
Ravi Luke Babu ◽  
Gurrala Sheelu ◽  
Ashlesha Deshpande
Keyword(s):  
Organic Synthesis ◽  
Candida Rugosa ◽  
Candida Rugosa Lipase ◽  
Enantiomerically Pure ◽  
Methyl Butyrate

Colostral milk fat percentage and pig performance are enhanced by feeding the leucine metabolite β-hydroxy-β-methyl butyrate to sows

1994 ◽  
Vol 72 (9) ◽  
pp. 2331-2337 ◽  
Author(s):  
Steven Nissen ◽  
Terry D. Faidley ◽  
Dean R. Zimmerman ◽  
Ryan Izard ◽  
Christian T. Fisher
Keyword(s):  
Milk Fat ◽  
Fat Percentage ◽  
Methyl Butyrate ◽  
Pig Performance ◽  
Leucine Metabolite

SUN-PO168: Modification in the Phase Angle and Body Composition in Malnourished Patients: Effect of Supplementation with Specific, Enriched in Β-Hydroxy Β-Methyl Butyrate Calcium

2019 ◽  
Vol 38 ◽  
pp. S121-S122
Author(s):  
J.M. Garcia-Almeida ◽  
I. Vegas-Aguilar ◽  
I. Cornejo-pareja ◽  
R. Rioja-Vázquez ◽  
I. Damas-Fuentes ◽  
...  
Keyword(s):  
Body Composition ◽  
Phase Angle ◽  
Methyl Butyrate

Methyl Butyrate

2011 ◽  
pp. 457-457
Author(s):  
Jan W. Gooch
Keyword(s):  
Methyl Butyrate

Beta-Hydroxy-Beta-Methyl-Butyrate, L-glutamine, and L-arginine Supplementation Improves Radiation-Induce Acute Intestinal Toxicity

2018 ◽  
Vol 16 (5) ◽  
pp. 576-591 ◽  
Author(s):  
Cagdas Yavas ◽  
Guler Yavas ◽  
Esin Celik ◽  
Ahmet Buyukyoruk ◽  
Cennet Buyukyoruk ◽  
...  
Keyword(s):  
Intestinal Toxicity ◽  
Methyl Butyrate ◽  
Arginine Supplementation

Synthesis of Methyl Butyrate Using Heterogeneous Catalyst: Kinetic Studies

2014 ◽  
Vol 144 (9) ◽  
pp. 1537-1546 ◽  
Author(s):  
P. N. Dange ◽  
A. Sharma ◽  
V. K. Rathod
Keyword(s):  
Heterogeneous Catalyst ◽  
Kinetic Studies ◽  
Methyl Butyrate
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