Structural Arrangement within a Peptide Fibril Derived from the Glaucoma-Associated Myocilin Olfactomedin Domain

Author(s):  
Yuan Gao ◽  
Emily G. Saccuzzo ◽  
Shannon E. Hill ◽  
Dustin J. E. Huard ◽  
Alicia S. Robang ◽  
...  
2020 ◽  
Vol 86 (1) ◽  
pp. 38-43
Author(s):  
Vladimir A. Kim ◽  
Valeriya V. Lysenko ◽  
Anna A. Afanaseva ◽  
Khasan I. Turkmenov

Structural degradation of the material upon long-term thermal and force impacts is a complex process which includes migration of the grain boundaries, diffusion of the active elements of the external and technological environment, hydrogen embrittlement, aging, grain boundary corrosion and other mechanisms. Application of the fractal and multifractal formalism to the description of microstructures opens up wide opportunities for quantitative assessment of the structural arrangement of the material, clarifies and reveals new aspects of the known mechanisms of structural transformations. Multifractal parameterization allows us to study the processes of structural degradation from the images of microstructures and identify structural changes that are hardly distinguishable visually. Any quantitative structural indicator can be used to calculate the multifractal spectra of the microstructure, but the most preferable is that provides the maximum range of variation in the numerical values of the multifractal components. The results of studying structural degradation of steel 15Kh5M upon continuous duty are presented. It is shown that structural degradation of steel during operation under high temperatures and stresses is accompanied by enlargement of the microstructural objects, broadening of the grain boundaries and allocation of the dispersed particles which are represented as point objects in the images. The processes of structural degradation lead to an increase in the range of changes in the components of the multifractal spectra. High values of complex indicators of structural arrangement indicate to an increase in heterogeneity and randomness at the micro-scale level, but at the same time, to manifestation of the ordered combinations of individual submicrostructures. Those structural transformations adapt the material to external impacts and provide the highest reliability and fracture resistance of the material.


1996 ◽  
Vol 37 (5) ◽  
pp. 786-790 ◽  
Author(s):  
S. A. Gromilov ◽  
S. A. Prokhorova ◽  
I. A. Baidina

Author(s):  
Sanya Ojo

Sieving through the avalanche of dissertations on the Pentecostal movements this chapter attempts to analyze the African Pentecostalism's structural arrangement to generate a deeper understanding of its operations and how the movement is re-inventing itself in contemporary epoch. This was done by appraising in-depth knowledge in concrete terms rather than in abstraction through the combination of notions of the market, entrepreneurship, diaspora, and development. Thus, the chapter develops a new sociological understanding of the differences and similarities between religion and the market in ethnic/diaspora entrepreneurship market space. It argues that the success of African Pentecostalism, both in Africa and the diaspora, is predicated on its ability to smoothly connect the past with the present. Whilst synthesis of African culture in the movement's liturgy is a proficient engagement with the past, inculcating the efficiency ethos of the market economy in its operations signifies a commitment to the present.


2020 ◽  
Vol 21 (14) ◽  
pp. 5161 ◽  
Author(s):  
Katarzyna Taylor ◽  
Krzysztof Sobczak

Alternative splicing is a highly sophisticated process, playing a significant role in posttranscriptional gene expression and underlying the diversity and complexity of organisms. Its regulation is multilayered, including an intrinsic role of RNA structural arrangement which undergoes time- and tissue-specific alterations. In this review, we describe the principles of RNA structural arrangement and briefly decipher its cis- and trans-acting cellular modulators which serve as crucial determinants of biological functionality of the RNA structure. Subsequently, we engage in a discussion about the RNA structure-mediated mechanisms of alternative splicing regulation. On one hand, the impairment of formation of optimal RNA structures may have critical consequences for the splicing outcome and further contribute to understanding the pathomechanism of severe disorders. On the other hand, the structural aspects of RNA became significant features taken into consideration in the endeavor of finding potential therapeutic treatments. Both aspects have been addressed by us emphasizing the importance of ongoing studies in both fields.


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