scholarly journals Liposome-Mediated Chemotherapeutic Delivery Is Synergistically Enhanced by Ternary Lipid Compositions and Cationic Lipids

Langmuir ◽  
2019 ◽  
Vol 35 (38) ◽  
pp. 12532-12542
Author(s):  
Andrea N. Trementozzi ◽  
Zachary I. Imam ◽  
Morgan Mendicino ◽  
Carl C. Hayden ◽  
Jeanne C. Stachowiak
Author(s):  
Dmitri Simberg ◽  
Sarah Weisman ◽  
Yeshayahu Talmon ◽  
Yechezkel Barenholz
Keyword(s):  

2020 ◽  
Vol 27 (8) ◽  
pp. 698-710
Author(s):  
Roya Cheraghi ◽  
Mahboobeh Nazari ◽  
Mohsen Alipour ◽  
Saman Hosseinkhani

Gene-based therapy largely relies on the vector type that allows a selective and efficient transfection into the target cells with maximum efficacy and minimal toxicity. Although, genes delivered utilizing modified viruses transfect efficiently and precisely, these vectors can cause severe immunological responses and are potentially carcinogenic. A promising method of overcoming this limitation is the use of non-viral vectors, including cationic lipids, polymers, dendrimers, and peptides, which offer potential routes for compacting DNA for targeted delivery. Although non-viral vectors exhibit reduced transfection efficiency compared to their viral counterpart, their superior biocompatibility, non-immunogenicity and potential for large-scale production make them increasingly attractive for modern therapy. There has been a great deal of interest in the development of biomimetic chimeric peptides. Biomimetic chimeric peptides contain different motifs for gene translocation into the nucleus of the desired cells. They have motifs for gene targeting into the desired cell, condense DNA into nanosize particles, translocate the gene into the nucleus and enhance the release of the particle into the cytoplasm. These carriers were developed in recent years. This review highlights the stepwise development of the biomimetic chimeric peptides currently being used in gene delivery.


RSC Advances ◽  
2020 ◽  
Vol 10 (56) ◽  
pp. 34247-34253
Author(s):  
Daichi Sawada ◽  
Ayana Hirono ◽  
Kouichi Asakura ◽  
Taisuke Banno

Giant vesicles composed of cationic lipids having an imine linkage and oleic acid were stable at strong acidic conditions.


ChemInform ◽  
2003 ◽  
Vol 34 (7) ◽  
Author(s):  
Man-Zhou Zhu ◽  
Qi-Hua Wu ◽  
Guisheng Zhang ◽  
Tan Ren ◽  
Dexi Liu ◽  
...  

2002 ◽  
Vol 70 (7) ◽  
pp. 3681-3688 ◽  
Author(s):  
S. D'Souza ◽  
V. Rosseels ◽  
O. Denis ◽  
A. Tanghe ◽  
N. De Smet ◽  
...  

ABSTRACT Mice were vaccinated with plasmid DNA (pDNA) encoding antigen 85A (Ag85A), Ag85B, or PstS-3 from Mycobacterium tuberculosis either in saline or formulated for intramuscular injections in VC1052:DPyPE (aminopropyl-dimethyl-myristoleyloxy-propanaminium bromide-diphytanoylphosphatidyl-ethanolamine) (Vaxfectin; Vical, Inc., San Diego, Calif.) or for intranasal instillations in GAP-DLRIE:DOPE (aminopropyl-dimethyl-bis-dodecyloxy-propanaminium bromide-dioleoylphosphatidyl-ethanolamine). These two novel cationic and neutral colipid formulations were previously reported to be effective adjuvants for pDNA-induced antibody responses. The levels of Ag85-specific total immunoglobulin G (IgG) and IgG isotypes were all increased 3- to 10-fold by formulation of pDNA in Vaxfectin. The level of production of splenic T-cell-derived Th1-type cytokines (interleukin-2 and gamma interferon) in response to purified Ag85 and to synthetic peptides spanning the entire Ag85A protein was also significantly higher in animals vaccinated with pDNA formulated in Vaxfectin. Cytolytic T-lymphocyte responses generated by pDNA encoding phosphate-binding protein PstS-3 in Vaxfectin were better sustained over time than were those generated by PstS-3 DNA in saline. Intranasal immunization with Ag85A DNA in saline was completely ineffective, whereas administration in GAP-DLRIE:DOPE induced a positive Th1-type cytokine response; however, the extent of the latter response was clearly lower than that obtained following intramuscular immunization with the same DNA dose. Combined intramuscular and intranasal administrations in cationic lipids resulted in stronger immune responses in the spleen and, more importantly, in the lungs as well. Finally, formulation in Vaxfectin increased the protective efficacy of the Ag85B DNA vaccine, as measured by reduced relative light unit counts and CFU counts in the spleen and lungs from mice challenged with bioluminescent M. tuberculosis H37Rv. These results may be of importance for future clinical use of DNA vaccines in humans.


2014 ◽  
Vol 12 (21) ◽  
pp. 3484-3492 ◽  
Author(s):  
Bao-Quan Liu ◽  
Wen-Jing Yi ◽  
Ji Zhang ◽  
Qiang Liu ◽  
Yan-Hong Liu ◽  
...  

Novel cyclen-based cationic lipids with asymmetric acyl-cholesteryl hydrophobic tails were synthesized and applied as non-viral gene vectors.


2005 ◽  
Vol 2 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Armandodoriano Bianco ◽  
Francesco Bonadies ◽  
Raffaella Napolitano ◽  
Giancarlo Ortaggi

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