Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones

2015 ◽  
Vol 17 (16) ◽  
pp. 3964-3967 ◽  
Author(s):  
Mariateresa Giustiniano ◽  
Valentina Mercalli ◽  
Jussara Amato ◽  
Ettore Novellino ◽  
Gian Cesare Tron
Keyword(s):  
Dual Role ◽  
One Pot ◽  
Nitrile Imines

ChemInform Abstract: Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones.

ChemInform ◽  
2016 ◽  
Vol 47 (1) ◽  
Author(s):  
Mariateresa Giustiniano ◽  
Valentina Mercalli ◽  
Jussara Amato ◽  
Ettore Novellino ◽  
Gian Cesare Tron
Keyword(s):  
Dual Role ◽  
One Pot ◽  
Nitrile Imines

Dual role of ethyl bromodifluoroacetate in the formation of fluorine-containing heteroaromatic compounds

2018 ◽  
Vol 54 (65) ◽  
pp. 8960-8963 ◽  
Author(s):  
Xingxing Ma ◽  
Shaoyu Mai ◽  
Yao Zhou ◽  
Gui-Juan Cheng ◽  
Qiuling Song
Keyword(s):  
Dual Role ◽  
Primary Amines ◽  
Cascade Process ◽  
One Pot ◽  
Heteroaromatic Compounds ◽  
First Time

An efficient one-pot cascade process via unprecedented quadruple cleavage of BrCF2COOEt with primary amines to afford valuable fluorine-containing heterocycles is described, in which BrCF2COOEt plays a dual role as a C1 synthon and a difluoroalkylating reagent for the first time.

scholarly journals One-pot synthesis of 1,3,5-triazine-2,4-dithione derivatives via three-component reactions

2020 ◽  
Vol 16 ◽  
pp. 1447-1455 ◽  
Author(s):  
Gui-Feng Kang ◽  
Gang Zhang
Keyword(s):  
Single Crystal ◽  
Dual Role ◽  
Spectroscopic Techniques ◽  
X Ray Diffraction ◽  
One Pot ◽  
Diverse Range ◽  
X Ray ◽  
One Pot Synthesis ◽  
Synthetic Strategy

A catalyst-free one-pot synthetic methodology was developed for the preparation of 1,3,5-triazine-2,4-dithione derivatives through three-component reactions of arylaldehydes, thiourea, and orthoformates. The procedure tolerated a diverse range of arylaldehydes and orthoformates and provided a rapid entry to a variety of 4-aryl-6-(alkylthio)-3,4-dihydro-1,3,5-triazine-2(1H)-thiones (29 examples). The synthetic strategy relies on the dual role of thiourea in the cyclization with the aldehydes and the alkylation via an intermediate imidate formation. The structures of 1,3,5-triazine-2,4-dithione derivatives were characterized by spectroscopic techniques as well as by single crystal X-ray diffraction.

Multicomponent cascade reaction: dual role of copper in the synthesis of 1,2,3-triazole tethered benzimidazo[1,2-a]quinoline and their photophysical studies

RSC Advances ◽  
2016 ◽  
Vol 6 (19) ◽  
pp. 15884-15894 ◽  
Author(s):  
Hunsur Nagendra Nagesh ◽  
Amaroju Suresh ◽  
Muthyala Nagarjuna Reddy ◽  
Narva Suresh ◽  
Jayanty Subbalakshmi ◽  
...  
Keyword(s):  
Cascade Reaction ◽  
Single Step ◽  
Dual Role ◽  
One Pot ◽  
One Pot Synthesis ◽  
Photophysical Studies

One-pot synthesis of 1,2,3-triazole tethered benzimidazo[1,2-a]quinolines through a multi-component reaction is demonstrated. Overall one C–C bond and three C–N bonds are formed in a single step.

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