Dual role of ethyl bromodifluoroacetate in the formation of fluorine-containing heteroaromatic compounds

2018 ◽  
Vol 54 (65) ◽  
pp. 8960-8963 ◽  
Author(s):  
Xingxing Ma ◽  
Shaoyu Mai ◽  
Yao Zhou ◽  
Gui-Juan Cheng ◽  
Qiuling Song
Keyword(s):  
Dual Role ◽  
Primary Amines ◽  
Cascade Process ◽  
One Pot ◽  
Heteroaromatic Compounds ◽  
First Time

An efficient one-pot cascade process via unprecedented quadruple cleavage of BrCF2COOEt with primary amines to afford valuable fluorine-containing heterocycles is described, in which BrCF2COOEt plays a dual role as a C1 synthon and a difluoroalkylating reagent for the first time.

ChemInform Abstract: Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones.

ChemInform ◽  
2016 ◽  
Vol 47 (1) ◽  
Author(s):  
Mariateresa Giustiniano ◽  
Valentina Mercalli ◽  
Jussara Amato ◽  
Ettore Novellino ◽  
Gian Cesare Tron
Keyword(s):  
Dual Role ◽  
One Pot ◽  
Nitrile Imines

scholarly journals Synthesis of Bis-2,3-dihydroquinazolin-4(1H)-ones and 2,3-Dihydroquinazolin-4(1H)-ones Derivatives with the Aid of Silica-Supported Preyssler Nanoparticles

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Ali Gharib ◽  
Bibi Robabeh Hashemipour Khorasani ◽  
Manouchehr Jahangir ◽  
Mina Roshani ◽  
Reza Safaee
Keyword(s):  
Primary Amine ◽  
Ammonium Carbonate ◽  
Aromatic Aldehydes ◽  
Product Yield ◽  
Primary Amines ◽  
Isatoic Anhydride ◽  
One Pot ◽  
High Yields ◽  
First Time

One-pot three-component condensation of isatoic anhydride with primary amines or ammonium carbonate and aromatic aldehydes in refluxing ethanol in the presence of catalytic amounts of silica-supported preyssler nanoparticles (SPNP) afforded the corresponding 2,3-dihydroquinazolin-4(1H)-ones in high yields, and bis-dihydroquinazolinones were synthesized for the first time by a novel pseudo-five-component condensation of isatoic anhydride, a primary amine, and a dialdehyde in water. The catalyst is reusable and can be applied several times without any decrease in product yield.

The amino side chains do matter: chemoselectivity in the one-pot three-component synthesis of 2-amino-4H-chromenes by supramolecular catalysis with amino-appended β-cyclodextrins (ACDs) in water

2016 ◽  
Vol 6 (12) ◽  
pp. 4283-4293 ◽  
Author(s):  
Yufeng Ren ◽  
Bo Yang ◽  
Xiali Liao
Keyword(s):  
Side Chains ◽  
One Pot ◽  
Supramolecular Catalysis ◽  
The One ◽  
First Time

The one-pot three-component synthesis of 2-amino-4H-chromenes was accomplished by supramolecular catalysis with well-designed amino-appended β-cyclodextrins (ACDs) in water, while the key role of amino side chains in chemoselectivity was determined for the first time.

First evidence of formation of stable DBU Zn-phthalocyanine complexes: synthesis and characterization

2005 ◽  
Vol 09 (07) ◽  
pp. 519-527 ◽  
Author(s):  
Roberta Del Sole ◽  
Agnese De Luca ◽  
Giuseppe Mele ◽  
Giuseppe Vasapollo
Keyword(s):  
Thermal Analysis ◽  
Axial Ligand ◽  
Synthesis And Characterization ◽  
One Pot ◽  
Strong Base ◽  
Pyridine Complex ◽  
The Stability ◽  
First Time ◽  
Complex Thermal Analysis

Novel Zn (II) phthalocyanine and naphthalocyanine DBU complexes have been prepared in a one-pot synthesis reacting phthalonitrile precursors with an excess of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). For the first time, it has been well evidenced that DBU played the role of coordinating axial ligand together with the well known role of strong base. Also, DBU complexes showed better solubility in organic solvents due to the coordination of the bulky axial DBU ligand, compared to the Zn (II) phthalocyanines and naphthalocyanines without coordinated DBU. The coordinating properties of DBU toward ZnPcs (DBU free) complexes have also been investigated along with the ZnPc (pyridine) complex. Thermal analysis results reflecting the stability of the synthesized complexes under air are also presented.

scholarly journals Hydrothermal Water Enabling One-Pot Transformation of Amines to Alcohols

2021 ◽  
Author(s):  
Lanxin Wu ◽  
Jiong Cheng ◽  
Xiaoguang Wang ◽  
Yang Yang
Keyword(s):  
Glutamic Acid ◽  
Nucleophilic Attack ◽  
Primary Amines ◽  
Primary Alcohols ◽  
Subsequent Reduction ◽  
One Pot ◽  
Selective Transformation ◽  
Catalytic Role ◽  
Hydrothermal Water

While the amination of primary alcohols to amines is quite normal, the reverse reaction, deamination of amines to alcohols is rare. Recent advances achieve the transformation by catalytic multistep processes. We report a one-pot method that enables water nucleophilic attack of amines through the unique catalytic role of hydrothermal water. By achieving dehydrogenation of amines or building targeting group, we fulfilled amines transformation by subsequent reduction or direct deamination, which could further link to the utilization of naturally abundant glutamic acid. The method avoids oxidants, catalysts or multistep, thus achieves simple, green and selective transformation of primary amines.

Benchmarking suppliers’ performance when some factors play the role of both inputs and outputs

2014 ◽  
Vol 21 (5) ◽  
pp. 792-813 ◽  
Author(s):  
Mahdi Mahdiloo ◽  
Abdollah Noorizadeh ◽  
Reza Farzipoor Saen
Keyword(s):  
Dual Role ◽  
Data Envelopment ◽  
Policy Makers ◽  
Content Type ◽  
Proposed Model ◽  
Complete Ranking ◽  
Evaluation Platform ◽  
First Time ◽  
Supplier Selection Problem

Purpose – The purpose of this paper is to develop a slack-based measure (SBM) model in the presence of dual-role factor. Then it is applied in supplier selection problem. Design/methodology/approach – The developed model in this paper is based on data envelopment analysis (DEA) technique. Findings – The proposed evaluation platform is capable of identifying ill-performing suppliers which seek to future improvement. The findings provide valuable insights for practitioners, as well as academicians, policy makers and also integrate selection criteria under the supply chain. Originality/value – This is the first time that a non-radial DEA model considers dual-role factors. The proposed model does not deal with dual-role factor as a non-discretionary factor. The proposed model considers dual-role factors on both the input and output sides in a similar manner. The proposed model can fully measure the inefficiency of suppliers. The proposed model can give a complete ranking of suppliers.

Exploiting the Electrophilic and Nucleophilic Dual Role of Nitrile Imines: One-Pot, Three-Component Synthesis of Furo[2,3-d]pyridazin-4(5H)-ones

2015 ◽  
Vol 17 (16) ◽  
pp. 3964-3967 ◽  
Author(s):  
Mariateresa Giustiniano ◽  
Valentina Mercalli ◽  
Jussara Amato ◽  
Ettore Novellino ◽  
Gian Cesare Tron
Keyword(s):  
Dual Role ◽  
One Pot ◽  
Nitrile Imines
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