scholarly journals Retraction of “Branched Glycerol-Based Copolymer with Ultrahigh p65 siRNA Delivery Efficiency for Enhanced Cancer Therapy”

2021 ◽  
Author(s):  
Li Zhou ◽  
Xiaoyan Qu ◽  
Yi Guo ◽  
Min Wang ◽  
Bo Lei ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Sirna Delivery ◽  
Delivery Efficiency

Branched Glycerol-Based Copolymer with Ultrahigh p65 siRNA Delivery Efficiency for Enhanced Cancer Therapy

2018 ◽  
Vol 10 (5) ◽  
pp. 4471-4480 ◽  
Author(s):  
Li Zhou ◽  
Xiaoyan Qu ◽  
Yi Guo ◽  
Min Wang ◽  
Bo Lei ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Sirna Delivery ◽  
Delivery Efficiency

Cancer Fighting SiRNA-RRM2 Loaded Nanorobots

2020 ◽  
Vol 8 (2) ◽  
pp. 79-90
Author(s):  
Arjun Sharma ◽  
Pravir Kumar ◽  
Rashmi K. Ambasta
Keyword(s):  
Cancer Therapy ◽  
Dna Synthesis ◽  
Cancer Progression ◽  
Sirna Delivery ◽  
Predictive Marker ◽  
The Body ◽  
Tumor Site ◽  
Target Delivery ◽  
Target Effect

Background: Silencing of several genes is critical for cancer therapy. These genes may be apoptotic gene, cell proliferation gene, DNA synthesis gene, etc. The two subunits of Ribonucleotide Reductase (RR), RRM1 and RRM2, are critical for DNA synthesis. Hence, targeting the blockage of DNA synthesis at tumor site can be a smart mode of cancer therapy. Specific targeting of blockage of RRM2 is done effectively by SiRNA. The drawbacks of siRNA delivery in the body include the poor uptake by all kinds of cells, questionable stability under physiological condition, non-target effect and ability to trigger the immune response. These obstacles may be overcome by target delivery of siRNA at the tumor site. This review presents a holistic overview regarding the role of RRM2 in controlling cancer progression. The nanoparticles are more effective due to specific characteristics like cell membrane penetration capacity, less toxicity, etc. RRM2 have been found to be elevated in different types of cancer and identified as the prognostic and predictive marker of the disease. Reductase RRM1 and RRM2 regulate the protein and gene expression of E2F, which is critical for protein expression and progression of cell cycle and cancer. The knockdown of RRM2 leads to apoptosis via Bcl2 in cancer. Both Bcl2 and E2F are critical in the progression of cancer, hence a gene that can affect both in regulating DNA replication is essential for cancer therapy. Aim: The aim of the review is to identify the related gene whose silencing may inhibit cancer progression. Conclusion: In this review, we illuminate the critical link between RRM-E2F, RRM-Bcl2, RRM-HDAC for the therapy of cancer. Altogether, this review presents an overview of all types of SiRNA targeted for cancer therapy with special emphasis on RRM2 for controlling the tumor progression.

scholarly journals Mono-arginine Cholesterol-based Small Lipid Nanoparticles as a Systemic siRNA Delivery Platform for Effective Cancer Therapy

Theranostics ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 192-203 ◽  
Author(s):  
Jinju Lee ◽  
Phei Er Saw ◽  
Vipul Gujrati ◽  
Yonghyun Lee ◽  
Hyungjun Kim ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Sirna Delivery ◽  
Lipid Nanoparticles ◽  
Delivery Platform ◽  
Effective Cancer Therapy

Anti-Her2 single-chain antibody mediated DNMTs-siRNA delivery for targeted breast cancer therapy

2012 ◽  
Vol 161 (3) ◽  
pp. 875-883 ◽  
Author(s):  
Shuang Dou ◽  
Yan-Dan Yao ◽  
Xian-Zhu Yang ◽  
Tian-Meng Sun ◽  
Cheng-Qiong Mao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Sirna Delivery ◽  
Single Chain ◽  
Breast Cancer Therapy ◽  
Single Chain Antibody

Black phosphorus quantum dot based novel siRNA delivery systems in human pluripotent teratoma PA-1 cells

2017 ◽  
Vol 5 (27) ◽  
pp. 5433-5440 ◽  
Author(s):  
Feng Yin ◽  
Kuan Hu ◽  
Si Chen ◽  
Dongyuan Wang ◽  
Jianing Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Quantum Dot ◽  
Transfection Efficiency ◽  
Sirna Delivery ◽  
Delivery Systems ◽  
Black Phosphorus ◽  
Semiconducting Materials ◽  
Photothermal Effects ◽  
Low Cytotoxicity

As a novel semiconducting materials, BP-QDs possess superior transfection efficiency, excellent biocompatibility and low cytotoxicity, which shows promising potential for siRNA delivery and photothermal effects in cancer therapy.

scholarly journals Evaluation of dendrimer type bio-reducible polymer as a siRNA delivery carrier for cancer therapy

2015 ◽  
Vol 209 ◽  
pp. 179-185 ◽  
Author(s):  
Joung-Pyo Nam ◽  
Kihoon Nam ◽  
Simhyun Jung ◽  
Jae-Woon Nah ◽  
Sung Wan Kim
Keyword(s):  
Cancer Therapy ◽  
Sirna Delivery

scholarly journals Efficient in vivo siRNA delivery by stabilized d-peptide-based lipid nanoparticles

RSC Advances ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 8823-8831 ◽  
Author(s):  
Tsogzolmaa Ganbold ◽  
Gerile Gerile ◽  
Hai Xiao ◽  
Huricha Baigude
Keyword(s):  
Sirna Delivery ◽  
Lipid Nanoparticles ◽  
Tissue Targeting ◽  
Delivery Efficiency

A lipid functionalized d-dipeptide has shown remarkable biocompatibility and tissue targeting as well as excellent RNAi delivery efficiency in vivo.

Structural exploration of hydrophobic core in polycationic micelles for improving siRNA delivery efficiency and cell viability

2019 ◽  
Vol 7 (6) ◽  
pp. 965-973 ◽  
Author(s):  
Wenjun Huang ◽  
Xiaoxia Wang ◽  
Changrong Wang ◽  
Lili Du ◽  
Jianhua Zhang ◽  
...  
Keyword(s):  
Cell Viability ◽  
Sirna Delivery ◽  
Hydrophobic Core ◽  
Delivery Efficiency

Improving siRNA delivery efficiency often encounters a dilemma with poor or decreased biocompatibility for polycationic micelles.

Redox-responsive polyprodrug nanoparticles for targeted siRNA delivery and synergistic liver cancer therapy

Biomaterials ◽  
2020 ◽  
Vol 234 ◽  
pp. 119760 ◽  
Author(s):  
Senlin Li ◽  
Phei Er Saw ◽  
Chunhao Lin ◽  
Yan Nie ◽  
Wei Tao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Sirna Delivery ◽  
Redox Responsive

Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?

Nanomedicine ◽  
2019 ◽  
Vol 14 (15) ◽  
pp. 2083-2100 ◽  
Author(s):  
Shahin Aghamiri ◽  
Keyvan Fallah Mehrjardi ◽  
Sasan Shabani ◽  
Mahsa Keshavarz-Fathi ◽  
Saeed Kargar ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Multidrug Resistance ◽  
Cancer Therapy ◽  
Sirna Delivery ◽  
Common Causes ◽  
The World ◽  
Causes Of Mortality ◽  
Delivery Strategies ◽  
Potential Strategy ◽  
Specific Ligand

Ovarian cancer is one of the most common causes of mortality throughout the world. Unfortunately, chemotherapy has failed to cure advanced cancers developing multidrug resistance (MDR). Moreover, it has critical side effects because of nonspecific toxicity. Thanks to specific silencing of oncogenes and MDR-associated genes, nano-siRNA drugs can be a great help address the limitations of chemotherapy. Here, we review the current advances in nanoparticle-mediated siRNA delivery strategies such as polymeric- and lipid-based systems, rigid nanoparticles and nanoparticles coupled to specific ligand systems. Nanoparticle-based codelivery of anticancer drugs and siRNA targeting various mechanisms of MDR is a cutting-edge strategy for ovarian cancer therapy, which is completely discussed in this review.

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