Experimental Mixture Design as a Tool for the Synthesis of Antimicrobial Selective Molecularly Imprinted Monodisperse Microbeads

2015 ◽  
Vol 7 (20) ◽  
pp. 10966-10976 ◽  
Author(s):  
Elena Benito-Peña ◽  
Fernando Navarro-Villoslada ◽  
Sergio Carrasco ◽  
Steffen Jockusch ◽  
M. Francesca Ottaviani ◽  
...  
Keyword(s):  
Mixture Design ◽  
Molecularly Imprinted ◽  
Experimental Mixture

Experimental mixture design as a tool to evaluate coumarin (1,2-benzopyrone) extraction from Dipteryx odorata seeds

2022 ◽  
pp. 114586
Author(s):  
Maria Lourdes Leite Moraes ◽  
Sabrina Aparecida Silva ◽  
Heron Dominguez Torres Silva
Keyword(s):  
Mixture Design ◽  
Experimental Mixture ◽  
Dipteryx Odorata

Optimization of β-Casein Stabilized Nanoemulsions Using Experimental Mixture Design

2011 ◽  
Vol 76 (8) ◽  
pp. C1108-C1117 ◽  
Author(s):  
Patrick G. Maher ◽  
Mark A. Fenelon ◽  
Yankun Zhou ◽  
Md. Kamrul Haque ◽  
Yrjö H. Roos
Keyword(s):  
Mixture Design ◽  
Experimental Mixture

Experimental mixture design solvent effects on pigment extraction and antioxidant activity from Coffea arabica L. leaves

2019 ◽  
Vol 146 ◽  
pp. 713-721 ◽  
Author(s):  
Gustavo G. Marcheafave ◽  
Cláudia D. Tormena ◽  
Elis Daiane Pauli ◽  
Miroslava Rakocevic ◽  
Roy E. Bruns ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Solvent Effects ◽  
Coffea Arabica ◽  
Mixture Design ◽  
Experimental Mixture ◽  
Pigment Extraction ◽  
Coffea Arabica L

scholarly journals Experimental mixture design as a tool to optimize the growth of variousGanodermaspecies cultivated on media with different sugars

2016 ◽  
Vol 7 (1) ◽  
pp. 36-44
Author(s):  
Yit Kheng Goh ◽  
Nurul Fadhilah Marzuki ◽  
Suet Yee Tan ◽  
Swee Sian Tan ◽  
Hun Jiat Tung ◽  
...  
Keyword(s):  
Mixture Design ◽  
Experimental Mixture

Optimisation of synergistic biomass-degrading enzyme systems for efficient rice straw hydrolysis using an experimental mixture design

2012 ◽  
Vol 119 ◽  
pp. 252-261 ◽  
Author(s):  
Surisa Suwannarangsee ◽  
Benjarat Bunterngsook ◽  
Jantima Arnthong ◽  
Atchara Paemanee ◽  
Arinthip Thamchaipenet ◽  
...  
Keyword(s):  
Rice Straw ◽  
Mixture Design ◽  
Degrading Enzyme ◽  
Experimental Mixture ◽  
Enzyme Systems

Experimental mixture design as a tool to enhance glycosyl hydrolases production by a new Trichoderma harzianum P49P11 strain cultivated under controlled bioreactor submerged fermentation

2013 ◽  
Vol 132 ◽  
pp. 401-405 ◽  
Author(s):  
Priscila da Silva Delabona ◽  
Cristiane Sanchez Farinas ◽  
Deise Juliana da Silva Lima ◽  
José Geraldo da Cruz Pradella
Keyword(s):  
Trichoderma Harzianum ◽  
Submerged Fermentation ◽  
Mixture Design ◽  
Glycosyl Hydrolases ◽  
Experimental Mixture

Screening and cocktail optimization using experimental mixture design: enzymatic saccharification as a biological pretreatment strategy

2021 ◽  
Author(s):  
Vanessa Elisa Pinheiro ◽  
Ilona Sárvári Horváth ◽  
Magnus Lundin ◽  
Maria de Lourdes Teixeira de Moraes Polizeli
Keyword(s):  
Enzymatic Saccharification ◽  
Mixture Design ◽  
Biological Pretreatment ◽  
Experimental Mixture

scholarly journals Solid dispersions with carbamazepine: Optimization of formulation, characterization and examination of long-term stability

2018 ◽  
Vol 72 (4) ◽  
pp. 191-204 ◽  
Author(s):  
Marko Krstic ◽  
Igor Lukic ◽  
Alma Busatlic ◽  
Nenad Lazarevic ◽  
Dragana Vasiljevic
Keyword(s):  
Solid State ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Mixture Design ◽  
Active Pharmaceutical Ingredients ◽  
Ambient Conditions ◽  
Experimental Mixture ◽  
Pharmaceutical Ingredients ◽  
Pharmacologically Active

Solid dispersions are defined as dispersions of one or more active pharmaceutical ingredients in inert solid-state carriers. They are made with the aim to increase solubility and the dissolution rate of low solubility active pharmaceutical ingredients, with the subsequent increase in their bioavailability. The aim of this study was the development and optimization of solid dispersion formulations with carbamazepine, using D-optimal experimental design, in order to increase the dissolution rate of the selected model drug. By using the method of experimental mixture design, solid dispersions were formulated by varying the ratio of carbamazepine (30-50 %), Gelucire? 44/14 (20-40 %) and Soluplus? polymer (30-50 %) (input parameters). Sixteen formulations were made and used for in vitro testing of the carbamazepine dissolution rate. The observed output parameters were the percentages of carbamazepine released after 10, 20, 30, 45, and 60 minutes. After the data analysis, three test formulations were chosen from different parts of the optimization area. They were prepared and the carbamazepine dissolution rate was determined, followed by stability assessment for 24 months under ambient conditions (25?C, 40 % RH). The highest dissolution rate of carbamazepine from solid dispersions (more than 80 % in 30 minutes) was achieved at the carbamazepine mass fraction of about 40 %, Soluplus? of about 45 % and Gelucire? 44/14 of about 25 %. Comparing the predicted and the experimental obtained release rate profiles of carbamazepine from the three prepared optimized formulations, a significant compliance of the results was observed (f1<15; f2>50). The application of the PAMPA (Parallel Artificial-Membrane Permeability Assay) test has shown that carbamazepine premeability was maintained and mildly increased in two out of the three tested optimzed solid state formulations. Raman spectroscopy, FT-IR and DSC analyes showed that in the three optimized solid dispersions, after preparation and 24 months of storage, interactions between carbamazepine and the excipients were not present and that carbamazepine remained in the single pharmacologically active crystal polymorph form III. Proper selection of solid dispersion proportions of carbamazepine, Gelucire? 44/14 and Soluplus? may significantly increase the dissolution rate of the active substance, and the method of experimental mixture design can be successfully used for optimization of these formulations.

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