Bioengineered Osteoinductive Broussonetia kazinoki/Silk Fibroin Composite Scaffolds for Bone Tissue Regeneration

2017 ◽  
Vol 9 (2) ◽  
pp. 1384-1394 ◽  
Author(s):  
Do Kyung Kim ◽  
Jeong In Kim ◽  
Tae In Hwang ◽  
Bo Ra Sim ◽  
Gilson Khang
Keyword(s):  
Bone Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Composite Scaffolds

scholarly journals Composite Scaffolds Containing Silk Fibroin, Gelatin, and Hydroxyapatite for Bone Tissue Regeneration and 3D Cell Culturing

Acta Naturae ◽  
2014 ◽  
Vol 6 (1) ◽  
pp. 96-101 ◽  
Author(s):  
M. M. Moisenovich ◽  
A. Yu. Arkhipova ◽  
A. A. Orlova ◽  
M. S. Drutskaya ◽  
S. V. Volkova ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Three Dimensional ◽  
Experimental Models ◽  
Bone Tissue Regeneration ◽  
Artificial Organ ◽  
Composite Scaffolds ◽  
Complex Processes ◽  
Healing Bone

Three-dimensional (3D) silk fibroin scaffolds were modified with one of the major bone tissue derivatives (nano-hydroxyapatite) and/or a collagen derivative (gelatin). Adhesion and proliferation of mouse embryonic fibroblasts (MEF) within the scaffold were increased after modification with either nano-hydroxyapatite or gelatin. However, a significant increase in MEF adhesion and proliferation was observed when both additives were introduced into the scaffold. Such modified composite scaffolds provide a new and better platform to study wound healing, bone and other tissue regeneration, as well as artificial organ bioengineering. This system can further be applied to establish experimental models to study cell-substrate interactions, cell migration and other complex processes, which may be difficult to address using the conventional two-dimensional culture systems.

scholarly journals Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration

2021 ◽  
Vol 22 (13) ◽  
pp. 6794
Author(s):  
Jae-Woo Kim ◽  
Yoon-Soo Han ◽  
Hyun-Mee Lee ◽  
Jin-Kyung Kim ◽  
Young-Jin Kim
Keyword(s):  
Hyaluronic Acid ◽  
Bone Tissue ◽  
Double Layer ◽  
Tissue Regeneration ◽  
Great Influence ◽  
Morphological Characteristics ◽  
Bone Tissue Regeneration ◽  
Hierarchical Architecture ◽  
Uniform Structure ◽  
Composite Scaffolds

The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone. This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration. The resulting scaffolds exhibited uniform structure and homogeneous pore distribution. In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture. The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation. In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds. According to these results, biomineralization has a great influence on the biological activity of cells. Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.

Engineering 3D printed bioactive composite scaffolds based on the combination of aliphatic polyester and calcium phosphates for bone tissue regeneration

2021 ◽  
Vol 122 ◽  
pp. 111928
Author(s):  
Eduardo H. Backes ◽  
Emanuel M. Fernandes ◽  
Gabriela S. Diogo ◽  
Catarina F. Marques ◽  
Tiago H. Silva ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Phosphates ◽  
Bone Tissue Regeneration ◽  
Aliphatic Polyester ◽  
Composite Scaffolds ◽  
3D Printed

Biocompatibility of plasma-treated poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofiber mats modified by silk fibroin for bone tissue regeneration

2016 ◽  
Vol 68 ◽  
pp. 842-850 ◽  
Author(s):  
Irem Unalan ◽  
Oylum Colpankan ◽  
Aylin Ziylan Albayrak ◽  
Cansu Gorgun ◽  
Aylin Sendemir Urkmez
Keyword(s):  
Bone Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Nanofiber Mats

Silk fibroin membrane used for guided bone tissue regeneration

2017 ◽  
Vol 70 ◽  
pp. 148-154 ◽  
Author(s):  
Yurong Cai ◽  
Junmao Guo ◽  
Cen Chen ◽  
Chenxue Yao ◽  
Sung-Min Chung ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Silk Fibroin ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration
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