Engineering 3D printed bioactive composite scaffolds based on the combination of aliphatic polyester and calcium phosphates for bone tissue regeneration

2021 ◽  
Vol 122 ◽  
pp. 111928
Author(s):  
Eduardo H. Backes ◽  
Emanuel M. Fernandes ◽  
Gabriela S. Diogo ◽  
Catarina F. Marques ◽  
Tiago H. Silva ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Calcium Phosphates ◽  
Bone Tissue Regeneration ◽  
Aliphatic Polyester ◽  
Composite Scaffolds ◽  
3D Printed

3D-printed PCL/bioglass (BGS-7) composite scaffolds with high toughness and cell-responses for bone tissue regeneration

2019 ◽  
Vol 79 ◽  
pp. 163-171 ◽  
Author(s):  
YongBok Kim ◽  
Jun Young Lim ◽  
Gi Hoon Yang ◽  
Jun-Hyuk Seo ◽  
Hyun-Seung Ryu ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Composite Scaffolds ◽  
Cell Responses ◽  
High Toughness ◽  
3D Printed

scholarly journals Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration

2021 ◽  
Vol 22 (13) ◽  
pp. 6794
Author(s):  
Jae-Woo Kim ◽  
Yoon-Soo Han ◽  
Hyun-Mee Lee ◽  
Jin-Kyung Kim ◽  
Young-Jin Kim
Keyword(s):  
Hyaluronic Acid ◽  
Bone Tissue ◽  
Double Layer ◽  
Tissue Regeneration ◽  
Great Influence ◽  
Morphological Characteristics ◽  
Bone Tissue Regeneration ◽  
Hierarchical Architecture ◽  
Uniform Structure ◽  
Composite Scaffolds

The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone. This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration. The resulting scaffolds exhibited uniform structure and homogeneous pore distribution. In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture. The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation. In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds. According to these results, biomineralization has a great influence on the biological activity of cells. Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.

Redefining architectural effects in 3D printed scaffolds through rational design for optimal bone tissue regeneration

2021 ◽  
Vol 25 ◽  
pp. 101168
Author(s):  
Mohammad Mirkhalaf ◽  
Xiao Wang ◽  
Ali Entezari ◽  
Colin R. Dunstan ◽  
Xinquan Jiang ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Rational Design ◽  
Bone Tissue Regeneration ◽  
3D Printed ◽  
Architectural Effects

Clinical relevance of sub-micron textured calcium phosphates for bone tissue regeneration

2018 ◽  
Vol 5 (7) ◽  
pp. 15501-15505 ◽  
Author(s):  
Florence Barrère-de Groot ◽  
Huipin Yuan ◽  
Joost D. de Bruijn
Keyword(s):  
Bone Tissue ◽  
Tissue Regeneration ◽  
Clinical Relevance ◽  
Calcium Phosphates ◽  
Bone Tissue Regeneration

Ornamenting 3D printed scaffolds with cell-laid extracellular matrix for bone tissue regeneration

Biomaterials ◽  
2015 ◽  
Vol 37 ◽  
pp. 230-241 ◽  
Author(s):  
Falguni Pati ◽  
Tae-Ha Song ◽  
Girdhari Rijal ◽  
Jinah Jang ◽  
Sung Won Kim ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
3D Printed
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