Electrospun poly (lactic-co-glycolic acid)/ multiwalled carbon nanotubes composite scaffolds for guided bone tissue regeneration

Biocomposite scaffolds of poly (lactic-co-glycolic acid) (PLGA), multiwalled carbon nanotubes (MWNTs), and hydroxyapatite (HA) nanoparticles were fabricated by gas-foaming and particle-leaching technique. The structure, surface morphology, and some properties of these PLGA/MWNTs/HA composites were evaluated. MWNTs and HA were evenly scattered in the scaffolds. The porosity of scaffols were decreased when the content of MWNTs increased to 1wt%. The mechanical strength of scaffols can be strengthened by the the addition of 1wt% MWNTs. The PLGA/MWNTs/HA biocomposite scaffolds have the great potential application in bone tissue regeneration.

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Incorporation of carboxylation multiwalled carbon nanotubes into biodegradable poly(lactic-co-glycolic acid) for bone tissue engineering

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2010.12.011 ◽

2011 ◽

Vol 83 (2) ◽

pp. 367-375 ◽

Cited By ~ 64

Author(s):

Cuilin Lin ◽

Yifang Wang ◽

Youqun Lai ◽

Wei Yang ◽

Fei Jiao ◽

...

Keyword(s):

Carbon Nanotubes ◽

Tissue Engineering ◽

Bone Tissue Engineering ◽

Bone Tissue ◽

Multiwalled Carbon Nanotubes ◽

Glycolic Acid ◽

Multiwalled Carbon ◽

Biodegradable Poly

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Effect of Morphological Characteristics and Biomineralization of 3D-Printed Gelatin/Hyaluronic Acid/Hydroxyapatite Composite Scaffolds on Bone Tissue Regeneration

International Journal of Molecular Sciences ◽

10.3390/ijms22136794 ◽

2021 ◽

Vol 22 (13) ◽

pp. 6794

Author(s):

Jae-Woo Kim ◽

Yoon-Soo Han ◽

Hyun-Mee Lee ◽

Jin-Kyung Kim ◽

Young-Jin Kim

Keyword(s):

Hyaluronic Acid ◽

Bone Tissue ◽

Double Layer ◽

Tissue Regeneration ◽

Great Influence ◽

Morphological Characteristics ◽

Bone Tissue Regeneration ◽

Hierarchical Architecture ◽

Uniform Structure ◽

Composite Scaffolds

The use of porous three-dimensional (3D) composite scaffolds has attracted great attention in bone tissue engineering applications because they closely simulate the major features of the natural extracellular matrix (ECM) of bone. This study aimed to prepare biomimetic composite scaffolds via a simple 3D printing of gelatin/hyaluronic acid (HA)/hydroxyapatite (HAp) and subsequent biomineralization for improved bone tissue regeneration. The resulting scaffolds exhibited uniform structure and homogeneous pore distribution. In addition, the microstructures of the composite scaffolds showed an ECM-mimetic structure with a wrinkled internal surface and a porous hierarchical architecture. The results of bioactivity assays proved that the morphological characteristics and biomineralization of the composite scaffolds influenced cell proliferation and osteogenic differentiation. In particular, the biomineralized gelatin/HA/HAp composite scaffolds with double-layer staggered orthogonal (GEHA20-ZZS) and double-layer alternative structure (GEHA20-45S) showed higher bioactivity than other scaffolds. According to these results, biomineralization has a great influence on the biological activity of cells. Hence, the biomineralized composite scaffolds can be used as new bone scaffolds in bone regeneration.

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