Silica Nanoparticle as a Lymph Node Targeting Platform for Vaccine Delivery

2017 ◽  
Vol 9 (28) ◽  
pp. 23466-23475 ◽  
Author(s):  
Myunggi An ◽  
Meng Li ◽  
Jingchao Xi ◽  
Haipeng Liu
Keyword(s):  
Lymph Node ◽  
Vaccine Delivery ◽  
Silica Nanoparticle ◽  
Lymph Node Targeting

scholarly journals Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes

2021 ◽  
pp. 153537022110107
Author(s):  
Noah Trac ◽  
Eun Ji Chung
Keyword(s):  
Drug Delivery ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Metastasis ◽  
Subcutaneous Administration ◽  
Mononuclear Phagocyte ◽  
Intravenous Drug ◽  
Rapid Clearance ◽  
Nanoparticle Design ◽  
Lymph Node Targeting

The lymph nodes are major sites of cancer metastasis and immune activity, and thus represent important clinical targets. Although not as well-studied compared to subcutaneous administration, intravenous drug delivery is advantageous for lymph node delivery as it is commonly practiced in the clinic and has the potential to deliver therapeutics systemically to all lymph nodes. However, rapid clearance by the mononuclear phagocyte system, tight junctions of the blood vascular endothelium, and the collagenous matrix of the interstitium can limit the efficiency of lymph node drug delivery, which has prompted research into the design of nanoparticle-based drug delivery systems. In this mini review, we describe the physiological and biological barriers to lymph node targeting, how they inform nanoparticle design, and discuss the future outlook of lymph node targeting.

Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma

2005 ◽  
Vol 21 (8) ◽  
pp. 705-708 ◽  
Author(s):  
Vladimir Bobek ◽  
Katarina Kolostova ◽  
Daniela Pinterov ◽  
Michael Boubelik ◽  
Ping Jiang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Green Fluorescent Protein ◽  
Lung Carcinoma ◽  
Lewis Lung Carcinoma ◽  
Fluorescent Protein ◽  
Lewis Lung ◽  
Lymph Node Targeting ◽  
Green Fluorescent

Lymph Node — Targeting Delivery of Adriamycin by Liposomal Administration into Gastric Submucosa in Rabbits

1993 ◽  
pp. 360-362
Author(s):  
Yoshimi Akamo ◽  
Isamu Mizuno ◽  
Toshihisa Yotsuyanagi ◽  
Tatsuo Ichino ◽  
Noritaka Tanimoto ◽  
...  
Keyword(s):  
Lymph Node ◽  
Targeting Delivery ◽  
Lymph Node Targeting

pH-Responsive Biomimetic Polymeric Micelles as Lymph Node-Targeting Vaccines for Enhanced Antitumor Immune Responses

2020 ◽  
Vol 21 (7) ◽  
pp. 2818-2828 ◽  
Author(s):  
Xiqin Yang ◽  
Tong Yu ◽  
Yingping Zeng ◽  
Keke Lian ◽  
Xueqing Zhou ◽  
...  
Keyword(s):  
Lymph Node ◽  
Immune Responses ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
Lymph Node Targeting

Innovations in lymph node targeting nanocarriers

2021 ◽  
pp. 101534
Author(s):  
Jihoon Kim ◽  
Paul A. Archer ◽  
Susan N. Thomas
Keyword(s):  
Lymph Node ◽  
Lymph Node Targeting
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