On-Demand Drug Release from Dual-Targeting Small Nanoparticles Triggered by High-Intensity Focused Ultrasound Enhanced Glioblastoma-Targeting Therapy

2017 ◽  
Vol 9 (37) ◽  
pp. 31612-31625 ◽  
Author(s):  
Zimiao Luo ◽  
Kai Jin ◽  
Qiang Pang ◽  
Shun Shen ◽  
Zhiqiang Yan ◽  
...  
Keyword(s):  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Targeting Therapy ◽  
On Demand ◽  
Dual Targeting ◽  
Small Nanoparticles

scholarly journals Investigation of the Inertial Cavitation Activity of Sonosensitive and Biocompatible Nanoparticles for Drug Delivery Applications Employing High Intensity Focused Ultrasound

2019 ◽  
Vol 5 (1) ◽  
pp. 585-588
Author(s):  
Benedikt George ◽  
Michael Fink ◽  
Helmut Ermert ◽  
Stefan J. Rupitsch ◽  
Pia T. Hiltl ◽  
...  
Keyword(s):  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Active Drug ◽  
Drug Carriers ◽  
High Intensity Focused Ultrasound ◽  
Activity Level ◽  
Inertial Cavitation ◽  
Cavitation Effect ◽  
Cavitation Activity

AbstractAn approach to improve chemotherapy, while minimizing side effects, is a local drug release close to the tumorous tissue. For this purpose, the active drug component is often bound to nanoparticles employed as drug carriers. In the present study, we investigate sonosensitive, biocompatible poly-(L)-lactic acid (PLA) nanoparticles, which shall be used as drug carriers. For drug release, High Intensity Focused Ultrasound (HIFU) will be employed to introduce inertial cavitation, which separates the active drug component from the drug carrier. The cavitation effect generates an acoustic noise signal, which characterizes the cavitation activity and is expected to serve simultaneously as an indicator for the release of the active drug component. Depending on the ultrasound frequency, different acoustic levels of the inertial cavitation activity were measured. Investigations using a setup for passive cavitation detection (PCD) deliver quantitative results regarding the frequency dependence of the cavitation activity level of nanoparticles and reference media.

scholarly journals Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound

Nanoscale ◽  
2017 ◽  
Vol 9 (21) ◽  
pp. 7063-7070 ◽  
Author(s):  
Meiyu Gai ◽  
Johannes Frueh ◽  
Tianyi Tao ◽  
Arseniy V. Petrov ◽  
Vladimir V. Petrov ◽  
...  
Keyword(s):  
Drug Release ◽  
Polylactic Acid ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound

Small hydrophilic molecules can be encapsulated in polylactic acid microchambers and released by HIFU.

Magnetic resonance imaging of high-intensity focused ultrasound-stimulated drug release from a self-reporting core@shell nanoparticle platform

2020 ◽  
Vol 56 (71) ◽  
pp. 10297-10300
Author(s):  
Chi-An Cheng ◽  
Wei Chen ◽  
Le Zhang ◽  
Holden H. Wu ◽  
Jeffrey I. Zink
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Core Shell ◽  
Resonance Imaging

A self-reporting theranostic approach that controls and “images” drug release from nanoparticles using magnetic resonance imaging-guided high-intensity focused ultrasound is presented.

Superhydrophobic Materials: Triggered Drug Release from Superhydrophobic Meshes using High-Intensity Focused Ultrasound (Adv. Healthcare Mater. 9/2013)

2013 ◽  
Vol 2 (9) ◽  
pp. 1182-1182
Author(s):  
Stefan T. Yohe ◽  
Jonathan A. Kopechek ◽  
Tyrone M. Porter ◽  
Yolonda L. Colson ◽  
Mark W. Grinstaff
Keyword(s):  
Drug Release ◽  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Triggered Drug Release
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