Cell-Permeable, MMP-2 Activatable, Nickel Ferrite and His-Tagged Fusion Protein Self-Assembled Fluorescent Nanoprobe for Tumor Magnetic-Targeting and Imaging

2017 ◽  
Vol 9 (45) ◽  
pp. 39209-39222 ◽  
Author(s):  
Lu Sun ◽  
Shuping Xie ◽  
Jing Qi ◽  
Ergang Liu ◽  
Di Liu ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Nickel Ferrite ◽  
Magnetic Targeting ◽  
Fluorescent Nanoprobe ◽  
Self Assembled

scholarly journals Targeting I/R Injury: A Self-Assembled Fluorescent Nanoprobe for Imaging and Therapy of Cardiac Ischemia/Reperfusion Injury (Adv. Therap. 3/2019)

2019 ◽  
Vol 2 (3) ◽  
pp. 1970005
Author(s):  
Melanie Ziegler ◽  
Xiaoqiu Xu ◽  
May Lin Yap ◽  
Houyuan Hu ◽  
Jianxiang Zhang ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cardiac Ischemia ◽  
Fluorescent Nanoprobe ◽  
Self Assembled

Development of a Multifunctional Nanobiointerface Based on Self-Assembled Fusion-Protein rSbpA/ZZ for Blood Cell Enrichment and Phenotyping

2017 ◽  
Vol 9 (39) ◽  
pp. 34423-34434 ◽  
Author(s):  
Mario Rothbauer ◽  
Martin Frauenlob ◽  
Karoline Gutkas ◽  
Michael B. Fischer ◽  
Eva-Kathrin Sinner ◽  
...  
Keyword(s):  
Blood Cell ◽  
Fusion Protein ◽  
Cell Enrichment ◽  
Self Assembled

A self-assembled fluorescent nanoprobe for detection of GSH and dual-channel imaging

2018 ◽  
Vol 355 ◽  
pp. 311-317 ◽  
Author(s):  
Yang Liu ◽  
Li-Ya Niu ◽  
Yu-Zhe Chen ◽  
Qing-Zheng Yang
Keyword(s):  
Fluorescent Nanoprobe ◽  
Dual Channel ◽  
Self Assembled

Ultra-homogeneous NIR-II fluorescent self-assembled nanoprobe with AIE properties for photothermal therapy of prostate cancer

Nanoscale ◽  
2021 ◽  
Author(s):  
Shengsheng Cui ◽  
Shanshan Fan ◽  
Haisong Tan ◽  
Yi Lu ◽  
Yiqian Zha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Uniform Size ◽  
Imaging Technology ◽  
Non Invasive ◽  
Fluorescent Nanoprobe ◽  
Self Assembled

Near-infrared two-zone (NIR-II) fluorescence imaging has attracted attention as a non-invasive imaging technology that provides centimeter-level depth and micron-level resolution. However, producing a NIR-II fluorescent nanoprobe with uniform size, high...

scholarly journals Self-Assembled Amyloid-Like Oligomeric-Cohesin Scaffoldin for Augmented Protein Display on the Saccharomyces cerevisiae Cell Surface

2012 ◽  
Vol 78 (9) ◽  
pp. 3249-3255 ◽  
Author(s):  
Zhenlin Han ◽  
Bei Zhang ◽  
Yi E. Wang ◽  
Yi Y. Zuo ◽  
Wei Wen Su
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cell Surface ◽  
Fusion Protein ◽  
Fold Increase ◽  
Scaffolding Protein ◽  
Yeast Display ◽  
Protein Scaffold ◽  
Content Type ◽  
Self Assembled ◽  
Novel Protein

ABSTRACTIn this study, a molecular self-assembly strategy to develop a novel protein scaffold for amplifying the extent and variety of proteins displayed on the surface ofSaccharomyces cerevisiaeis presented. The cellulosomal scaffolding protein cohesin and its upstream hydrophilic domain (HD) were genetically fused with the yeast Ure2p N-terminal fibrillogenic domain consisting of residues 1 to 80 (Ure2p1-80). The resulting Ure2p1-80-HD-cohesin fusion protein was successfully expressed inEscherichia colito produce self-assembled supramolecular nanofibrils that serve as a novel protein scaffold displaying multiple copies of functional cohesin domains. The amyloid-like property of the nanofibrils was confirmed via thioflavin T staining and atomic force microscopy. These cohesin nanofibrils attached themselves, via a green fluorescent protein (GFP)-dockerin fusion protein, to the cell surface ofS. cerevisiaeengineered to display a GFP-nanobody. The excess cohesin units on the nanofibrils provide ample sites for binding to dockerin fusion proteins, as exemplified using an mCherry-dockerin fusion protein as well as theClostridium cellulolyticumCelA endoglucanase. More than a 24-fold increase in mCherry fluorescence and an 8-fold increase in CelA activity were noted when the cohesin nanofibril scaffold-mediated yeast display was used, compared to using yeast display with GFP-cohesin that contains only a single copy of cohesin. Self-assembled supramolecular cohesin nanofibrils created by fusion with the yeast Ure2p fibrillogenic domain provide a versatile protein scaffold that expands the utility of yeast cell surface display.

A Self-Assembled Fluorescent Nanoprobe for Imaging and Therapy of Cardiac Ischemia/Reperfusion Injury

2019 ◽  
Vol 2 (3) ◽  
pp. 1800133 ◽  
Author(s):  
Melanie Ziegler ◽  
Xiaoqiu Xu ◽  
May Lin Yap ◽  
Houyuan Hu ◽  
Jianxiang Zhang ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cardiac Ischemia ◽  
Fluorescent Nanoprobe ◽  
Self Assembled

Self-Assembled Fluorescent Nanoprobe for the Detection of Fluoride Ions in Aqueous Solutions

2015 ◽  
Vol 88 (2) ◽  
pp. 327-329 ◽  
Author(s):  
Eiji Nakata ◽  
Yoshijiro Nazumi ◽  
Yoshihiro Yukimachi ◽  
Yoshihiro Uto ◽  
Hitoshi Hori ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Fluoride Ions ◽  
Fluorescent Nanoprobe ◽  
Self Assembled

Magnetic memory effect in self-assembled nickel ferrite nanoparticles having mesoscopic void spaces

RSC Advances ◽  
2016 ◽  
Vol 6 (51) ◽  
pp. 45701-45707 ◽  
Author(s):  
Vandana Kumari ◽  
Koushik Dey ◽  
Saurav Giri ◽  
Asim Bhaumik
Keyword(s):  
Memory Effect ◽  
Nickel Ferrite ◽  
Ferrite Nanoparticles ◽  
Interparticle Interaction ◽  
Magnetic Memory ◽  
Novel Approach ◽  
Nickel Ferrite Nanoparticles ◽  
Self Assembled

We report a novel approach for fabricating nanocrystalline and mesoporous nickel ferrite nanoparticles of ca. 5–9 nm size and it showed interesting memory effect as a consequence of interparticle interaction of self-assembled nanoparticles.

Self-assembled adhesive biomaterials formed by a genetically designed fusion protein

2018 ◽  
Vol 54 (89) ◽  
pp. 12642-12645 ◽  
Author(s):  
Pulakesh Aich ◽  
Jaeyeon An ◽  
Byeongseon Yang ◽  
Young Ho Ko ◽  
Junghyun Kim ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Adhesion Property ◽  
Underwater Adhesion ◽  
Genetic Fusion ◽  
Self Assembled ◽  
Mussel Foot Protein

A spider with mussel: a supramolecular fiber formed by a spider dragline protein was tuned to have underwater adhesion property by genetic fusion of a mussel foot protein.

scholarly journals Self-Assembled Fluorescent Nanoprobe Based on Forster Resonance Energy Transfer for Carbon Monoxide in Living Cells and Animals via Ligand Exchange

2018 ◽  
Vol 90 (12) ◽  
pp. 7117-7121 ◽  
Author(s):  
Ruizhen Jia ◽  
Pengfei Song ◽  
Jingjing Wang ◽  
Hengtang Mai ◽  
Sixian Li ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Energy Transfer ◽  
Ligand Exchange ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Living Cells ◽  
Förster Resonance Energy Transfer ◽  
Fluorescent Nanoprobe ◽  
Self Assembled ◽  
Förster Resonance
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