fluorescent nanoprobe
Recently Published Documents


TOTAL DOCUMENTS

187
(FIVE YEARS 108)

H-INDEX

27
(FIVE YEARS 9)

2022 ◽  
Vol 189 (2) ◽  
Author(s):  
Yanling Lv ◽  
Peihua Li ◽  
Chao Liu ◽  
Lian Xia ◽  
Fengli Qu ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Meijuan Chen ◽  
Zhousheng Lin ◽  
Guangyu Yao ◽  
Xi Hong ◽  
Xiaolei Xue ◽  
...  

TTRE, a photosensitizer molecule, has excellent biofluorescence imaging performance and effective antitumor properties for breast cancer. However, its application in breast cancer treatment is limited due to poor tumor selectivity and lack of targeting ability. In this study, TTRE and trastuzumab were combined to synthesize Tra-TTR-A, a novel near-infrared fluorescent nanoprobe for HER2 positive breast cancer. The targeting and antitumor abilities of Tra-TTR-A in breast cancer were also investigated. Like TTRE, Tra-TTR-A has a stable structure with remarkable optical properties and in vivo imaging capacity. However, Tra-TTR-A not only inhibits tumor growth by generating reactive oxygen species but also kills tumor cells by trastuzumab. In this study, Tra-TTR-A, a new type of near-infrared fluorescent nanoprobe that targets HER2-positive breast cancer, was successfully synthesized. Tra-TTR-A could be used in in vivo imaging, targeted photodynamic therapy, and diagnosis and treatment for breast cancer.


2021 ◽  
Vol 426 ◽  
pp. 131836
Author(s):  
Xiaodan Cheng ◽  
Shuai Zheng ◽  
Wenqi Wang ◽  
Han Han ◽  
Xingsheng Yang ◽  
...  

2021 ◽  
Vol 11 (11) ◽  
pp. 1781-1785
Author(s):  
Huizhu Zhang ◽  
Liang Ming ◽  
Tao Zhang ◽  
Baohui Guo ◽  
Yuguang Lv

Quinolones are widely used, but there are few reports on the application of fluorescent probe analysis. In this paper, we synthesized a tricyano-dihydrofuran (DCDHF-2-V) electron acceptor, and a (DCDHF-2-V)-quinolone fluorescent nanoprobe was designed. Its structure was characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR) and ultraviolet (UV). A novel tricyano-dihydrofuran-ofloxacin fluorescent nanoprobe was established for the first time by fluorescence spectrophotometry. A novel fluorescent nanoprobe was obtained and used in the determination of ofloxacin in vitro. The results showed that tricyano-dihydrofuran can form stable charge transfer complex with ofloxacin, and it can be used for the determination of ofloxacin in drugs as a fluorescent probe. While important experimental steps are for the first time achieved in this study for future Quinolone fluorescent nanoprobe implementations, this method is simple and sensitive.


Sign in / Sign up

Export Citation Format

Share Document