scholarly journals Poly(ethylene glycol)–Poly(beta-amino ester)-Based Nanoparticles for Suicide Gene Therapy Enhance Brain Penetration and Extend Survival in a Preclinical Human Glioblastoma Orthotopic Xenograft Model

2020 ◽  
Vol 6 (5) ◽  
pp. 2943-2955 ◽  
Author(s):  
Jayoung Kim ◽  
Sujan K. Mondal ◽  
Stephany Y. Tzeng ◽  
Yuan Rui ◽  
Rawan Al-kharboosh ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Ethylene Glycol ◽  
Xenograft Model ◽  
Suicide Gene ◽  
Suicide Gene Therapy ◽  
Amino Ester ◽  
Poly Ethylene Glycol ◽  
Brain Penetration ◽  
Orthotopic Xenograft Model ◽  
Poly Ethylene

Poly (amino ester) Composed of Poly (ethylene glycol) and Aminosilane Prepared by Combinatorial Chemistry as a Gene Carrier

2007 ◽  
Vol 25 (4) ◽  
pp. 875-885 ◽  
Author(s):  
Dhananjay Jere ◽  
Mi-Kyong Yoo ◽  
Rohidas Arote ◽  
Tae-Hee Kim ◽  
Myung-Haing Cho ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Combinatorial Chemistry ◽  
Gene Carrier ◽  
Amino Ester ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Copolymers of amine methacrylate with poly(ethylene glycol) as vectors for gene therapy

2001 ◽  
Vol 73 (2-3) ◽  
pp. 359-380 ◽  
Author(s):  
Uracha Rungsardthong ◽  
Mangesh Deshpande ◽  
Lindsey Bailey ◽  
M. Vamvakaki ◽  
Steven P. Armes ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Cleavable poly(ethylene glycol) branched chain-modified Antheraea pernyi silk fibroin as a gene delivery carrier

Nanomedicine ◽  
2021 ◽  
Author(s):  
Xueping Liu ◽  
Hong Luo ◽  
Longxing Niu ◽  
Yanfei Feng ◽  
Peng Pan ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Ethylene Glycol ◽  
Silk Fibroin ◽  
Plasma Proteins ◽  
Kidney Cells ◽  
Poly Ethylene Glycol ◽  
Normal Cells ◽  
Antheraea Pernyi ◽  
Poly Ethylene ◽  
Branched Chain

Aim: To obtain a gene carrier that can effectively deliver loaded therapeutic genes to tumor cells, avoid toxic effects on normal cells and reduce nonspecific adsorption of plasma proteins. Methods: The conjugate of poly(ethylene glycol) (PEG) and MMP2SSP (PEG-MMP2SSP) was covalently coupled to cationized Antheraea pernyi silk fibroin (CASF) through disulfide bond exchange reaction to obtain a PEG-MMP2SSP-modified CASF (CASFMP). Results: The PEG chains were effectively cleaved from the CASFMP by MMP2. CASFMP/pDNA complexes inhibited human fibrosarcoma cell proliferation, and its cytotoxicity to human normal embryonic kidney cells was significantly lower than that of poly(ethylenimine)/pDNA after coculturing with cells for 24 h. Conclusion: CASFMP is a promising compound for use in gene therapy.

Poly(ethylene glycol)-Grafted Polyethylenimine Modified with G250 Monoclonal Antibody for Tumor Gene Therapy

2010 ◽  
Vol 21 (2) ◽  
pp. 191-198 ◽  
Author(s):  
Yajun Duan ◽  
Cuihong Yang ◽  
Zhenfang Zhang ◽  
Jianfeng Liu ◽  
Junnian Zheng ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Monoclonal Antibody ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Tumor Gene Therapy ◽  
Poly Ethylene ◽  
Tumor Gene
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