Poly(ethylene glycol)-Grafted Polyethylenimine Modified with G250 Monoclonal Antibody for Tumor Gene Therapy

2010 ◽  
Vol 21 (2) ◽  
pp. 191-198 ◽  
Author(s):  
Yajun Duan ◽  
Cuihong Yang ◽  
Zhenfang Zhang ◽  
Jianfeng Liu ◽  
Junnian Zheng ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Monoclonal Antibody ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Tumor Gene Therapy ◽  
Poly Ethylene ◽  
Tumor Gene

Efficient Clearance of Poly(ethylene glycol)-Modified Immunoenzyme with Anti-PEG Monoclonal Antibody for Prodrug Cancer Therapy

2000 ◽  
Vol 11 (2) ◽  
pp. 258-266 ◽  
Author(s):  
Tian-Lu Cheng ◽  
Bing-Mae Chen ◽  
Ji-Wang Chern ◽  
Ming-Fang Wu ◽  
Steve R. Roffler
Keyword(s):  
Monoclonal Antibody ◽  
Cancer Therapy ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Copolymers of amine methacrylate with poly(ethylene glycol) as vectors for gene therapy

2001 ◽  
Vol 73 (2-3) ◽  
pp. 359-380 ◽  
Author(s):  
Uracha Rungsardthong ◽  
Mangesh Deshpande ◽  
Lindsey Bailey ◽  
M. Vamvakaki ◽  
Steven P. Armes ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Cleavable poly(ethylene glycol) branched chain-modified Antheraea pernyi silk fibroin as a gene delivery carrier

Nanomedicine ◽  
2021 ◽  
Author(s):  
Xueping Liu ◽  
Hong Luo ◽  
Longxing Niu ◽  
Yanfei Feng ◽  
Peng Pan ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Ethylene Glycol ◽  
Silk Fibroin ◽  
Plasma Proteins ◽  
Kidney Cells ◽  
Poly Ethylene Glycol ◽  
Normal Cells ◽  
Antheraea Pernyi ◽  
Poly Ethylene ◽  
Branched Chain

Aim: To obtain a gene carrier that can effectively deliver loaded therapeutic genes to tumor cells, avoid toxic effects on normal cells and reduce nonspecific adsorption of plasma proteins. Methods: The conjugate of poly(ethylene glycol) (PEG) and MMP2SSP (PEG-MMP2SSP) was covalently coupled to cationized Antheraea pernyi silk fibroin (CASF) through disulfide bond exchange reaction to obtain a PEG-MMP2SSP-modified CASF (CASFMP). Results: The PEG chains were effectively cleaved from the CASFMP by MMP2. CASFMP/pDNA complexes inhibited human fibrosarcoma cell proliferation, and its cytotoxicity to human normal embryonic kidney cells was significantly lower than that of poly(ethylenimine)/pDNA after coculturing with cells for 24 h. Conclusion: CASFMP is a promising compound for use in gene therapy.

Hyaluronic Acid/Chitosan-g-Poly(ethylene glycol) Nanoparticles for Gene Therapy: An Application for pDNA and siRNA Delivery

2010 ◽  
Vol 27 (12) ◽  
pp. 2544-2555 ◽  
Author(s):  
Manuela Raviña ◽  
Eva Cubillo ◽  
David Olmeda ◽  
Ramón Novoa-Carballal ◽  
Eduardo Fernandez-Megia ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Hyaluronic Acid ◽  
Ethylene Glycol ◽  
Sirna Delivery ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Monoclonal Antibody-Based Quantitation of Poly(ethylene glycol)-Derivatized Proteins, Liposomes, and Nanoparticles

2005 ◽  
Vol 16 (5) ◽  
pp. 1225-1231 ◽  
Author(s):  
Tian-Lu Cheng ◽  
Chiu-Min Cheng ◽  
Bing-Mae Chen ◽  
Der-An Tsao ◽  
Kuo-Hsiang Chuang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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