A Hybrid Genipin-Cross-Linked Hydrogel/Nanostructured Lipid Carrier for Ocular Drug Delivery: Cellular, ex Vivo, and in Vivo Evaluation

2020 ◽  
Vol 6 (3) ◽  
pp. 1543-1552 ◽  
Author(s):  
Yibin Yu ◽  
Shuo Xu ◽  
Shihui Yu ◽  
Jinyu Li ◽  
Guoxin Tan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ex Vivo ◽  
Ocular Drug Delivery ◽  
Nanostructured Lipid Carrier ◽  
In Vivo Evaluation

Ocular Cubosome Drug Delivery System for Timolol Maleate: Preparation, Characterization, Cytotoxicity, Ex Vivo, and In Vivo Evaluation

2017 ◽  
Vol 18 (8) ◽  
pp. 2919-2926 ◽  
Author(s):  
Jiayuan Huang ◽  
Tingting Peng ◽  
Yanrong Li ◽  
Zhengwen Zhan ◽  
Youmei Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ex Vivo ◽  
Timolol Maleate ◽  
In Vivo Evaluation

scholarly journals Optimization of Novel Naproxen-Loaded Chitosan/Carrageenan Nanocarrier-Based Gel for Topical Delivery: Ex Vivo, Histopathological, and In Vivo Evaluation

2021 ◽  
Vol 14 (6) ◽  
pp. 557
Author(s):  
Sobia Noreen ◽  
Fahad Pervaiz ◽  
Akram Ashames ◽  
Manal Buabeid ◽  
Khairi Fahelelbom ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Ex Vivo ◽  
Skin Irritation ◽  
Control Group ◽  
Oral Toxicity ◽  
In Vivo Evaluation ◽  
Sustained Drug Delivery ◽  
Group A

Naproxen (NAP) is commonly used for pain, inflammation, and stiffness associated with arthritis. However, systemic administration is linked with several gastrointestinal tract (GIT) side effects. The present work aims to prepare and evaluate NAP nanoparticulate shells of chitosan (CS) and carrageenan (CRG) loaded into a Carbopol 940 (Ca-940) gel system with unique features of sustained drug delivery as well as improved permeation through a topical route. Moreover, this study aims to evaluate its ex vivo, histopathological, and in vivo anti-inflammatory activity in albino Wistar rats. The percentage of ex vivo drug permeation patterns in the optimized formulation (No) was higher (88.66%) than the control gel (36.195%). Oral toxicity studies of developed nanoparticles in albino rabbits showed that the NAP-loaded CS/CRG are non-toxic and, upon histopathological evaluation, no sign of incompatibility was observed compared to the control group. A In Vivo study showed that the optimized gel formulation (No) was more effective than the control gel (Nc) in treating arthritis-associated inflammation. The sustained permeation and the absence of skin irritation make this novel NAP nanoparticle-loaded gel based on CS/CRG a suitable drug delivery system for topical application and has the potential for improved patient compliance and reduced GIT-related side effects in arthritis.

Design of ocular drug delivery platforms and in vitro - in vivo evaluation of riboflavin to the cornea by non-interventional (epi-on) technique for keratoconus treatment

2020 ◽  
Vol 324 ◽  
pp. 238-249 ◽  
Author(s):  
Eren Aytekin ◽  
Naile Öztürk ◽  
İmran Vural ◽  
H. Kerem Polat ◽  
Hasan Basri Çakmak ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ocular Drug Delivery ◽  
In Vivo Evaluation
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