Parallel Screening Using the Chloroalkane Penetration Assay Reveals Structure-Penetration Relationships

2021 ◽  
Author(s):  
Kaley M. Mientkiewicz ◽  
Leila Peraro ◽  
Joshua A. Kritzer
Keyword(s):  
Parallel Screening

Rapid Parallel Screening for Strain Optimization

2012 ◽  
Author(s):  
Chuck Merryman
Keyword(s):  
Strain Optimization ◽  
Parallel Screening

scholarly journals Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

2021 ◽  
Vol 14 (3) ◽  
pp. 203 ◽  
Author(s):  
Shurong Hou ◽  
Juan Diez ◽  
Chao Wang ◽  
Christoph Becker-Pauly ◽  
Gregg B. Fields ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
De Novo ◽  
Selective Inhibitors ◽  
Preclinical Development ◽  
Starting Point ◽  
Good Starting Point ◽  
Parallel Screening ◽  
Low Cytotoxicity

Meprin α and β are zinc-dependent proteinases implicated in multiple diseases including cancers, fibrosis, and Alzheimer’s. However, until recently, only a few inhibitors of either meprin were reported and no inhibitors are in preclinical development. Moreover, inhibitors of other metzincins developed in previous years are not effective in inhibiting meprins suggesting the need for de novo discovery effort. To address the paucity of tractable meprin inhibitors we developed ultrahigh-throughput assays and conducted parallel screening of >650,000 compounds against each meprin. As a result of this effort, we identified five selective meprin α hits belonging to three different chemotypes (triazole-hydroxyacetamides, sulfonamide-hydroxypropanamides, and phenoxy-hydroxyacetamides). These hits demonstrated a nanomolar to micromolar inhibitory activity against meprin α with low cytotoxicity and >30-fold selectivity against meprin β and other related metzincincs. These selective inhibitors of meprin α provide a good starting point for further optimization.

scholarly journals Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
David J Taylor ◽  
Christine E Parsons ◽  
Haiyong Han ◽  
Arul Jayaraman ◽  
Kaushal Rege
Keyword(s):  
Cancer Cells ◽  
Antineoplastic Drugs ◽  
Parallel Screening ◽  
Induced Apoptosis ◽  
Apoptosis In Cancer Cells

scholarly journals Performance of parallel screening of Brazilian blood donors with two human immunodeficiency virus immunoassays: implications for sequential immunoassay testing algorithms in other countries

Transfusion ◽  
2011 ◽  
Vol 51 (1) ◽  
pp. 175-183 ◽  
Author(s):  
Ester C. Sabino ◽  
Nanci A. Salles ◽  
Cesar de Almeida-Neto ◽  
Angela M. Barreto ◽  
Fernando Basques ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Blood Donors ◽  
Immunodeficiency Virus ◽  
Testing Algorithms ◽  
Parallel Screening

Parallel screening for ALK, MET and ROS1 alterations in non-small cell lung cancer with implications for daily routine testing

Lung Cancer ◽  
2015 ◽  
Vol 87 (2) ◽  
pp. 122-129 ◽  
Author(s):  
Philipp Jurmeister ◽  
Dido Lenze ◽  
Erika Berg ◽  
Stefanie Mende ◽  
Frank Schäper ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Daily Routine ◽  
Small Cell Lung ◽  
Routine Testing ◽  
Parallel Screening

[29] Digital imaging spectroscopy for massively parallel screening of mutants

1995 ◽  
pp. 732-IN4 ◽  
Author(s):  
Douglas C. Youvan ◽  
Ellen Goldman ◽  
Simon Delagrave ◽  
Mary M. Yang
Keyword(s):  
Digital Imaging ◽  
Imaging Spectroscopy ◽  
Massively Parallel ◽  
Parallel Screening

scholarly journals Parallel Screening for Rapid Identification of Orthogonal Bioluminescent Tools

2017 ◽  
Vol 3 (12) ◽  
pp. 1254-1261 ◽  
Author(s):  
Colin M. Rathbun ◽  
William B. Porterfield ◽  
Krysten A. Jones ◽  
Marian J. Sagoe ◽  
Monique R. Reyes ◽  
...  
Keyword(s):  
Rapid Identification ◽  
Parallel Screening

Label-Free Parallel Screening of Combinatorial Triazine Libraries Using Reflectometric Interference Spectroscopy

2002 ◽  
Vol 74 (4) ◽  
pp. 834-840 ◽  
Author(s):  
Oliver Birkert ◽  
Rolf Tünnemann ◽  
Günther Jung ◽  
Günter Gauglitz
Keyword(s):  
Label Free ◽  
Reflectometric Interference Spectroscopy ◽  
Parallel Screening
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