Bcl-2-Homology-Only Proapoptotic Peptides Modulate β-Amyloid Aggregation and Toxicity

2021 ◽  
Author(s):  
Shani Ben-Zichri ◽  
Ravit Malishev ◽  
Ofek Oren ◽  
Daniel N. Bloch ◽  
Ran Taube ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Proapoptotic Peptides ◽  
Β Amyloid

Аnticholinesterase and antioxidant activity of new binary conjugates of (с)-carbolines

2019 ◽  
Vol 484 (1) ◽  
pp. 104-108
Author(s):  
G. F. Makhaeva ◽  
E. F. Shevtsova ◽  
N. P. Boltneva ◽  
N. V. Kovaleva ◽  
E. V. Rudakova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antioxidant Activity ◽  
Anticholinesterase Activity ◽  
Amyloid Aggregation ◽  
Varying Length ◽  
Β Amyloid ◽  
New Compounds

This study presents the synthesis of binary tetrohydro-γ-carbolines with ditriazol spacers of varying length, which exhibit anticholinesterase and antioxidant activity, as compared to the original Dimebon prototype. Anticholinesterase activity suggests the potential ability of the new compounds to block β-amyloid aggregation induced by anticholinesterase, making them promising candidates for further research preparations for the treatment of Alzheimer's disease. Particular attention should be paid to the conjugate with an intertriazol hexamethylene spacer, which can be regarded as the leading compound in this series.

Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines

2012 ◽  
Vol 33 (3) ◽  
pp. 482-490 ◽  
Author(s):  
Shao-wei Wang ◽  
Yu-Jiong Wang ◽  
Ya-jing Su ◽  
Wei-wei Zhou ◽  
Shi-gao Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Proinflammatory Cytokines ◽  
Amyloid Aggregation ◽  
Β Amyloid

Role of Acetylcholinesterase in β-Amyloid Aggregation Studied by Accelerated Molecular Dynamics

2016 ◽  
Vol 7 (2) ◽  
pp. 396-402 ◽  
Author(s):  
Sofya V. Lushchekina ◽  
Ekaterina D. Kots ◽  
Dana A. Novichkova ◽  
Konstantin A. Petrov ◽  
Patrick Masson
Keyword(s):  
Molecular Dynamics ◽  
Amyloid Aggregation ◽  
Accelerated Molecular Dynamics ◽  
Β Amyloid

β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies

2003 ◽  
Vol 65 (3) ◽  
pp. 407-416 ◽  
Author(s):  
Manuela Bartolini ◽  
Carlo Bertucci ◽  
Vanni Cavrini ◽  
Vincenza Andrisano
Keyword(s):  
Acetylcholinesterase Inhibition ◽  
Amyloid Aggregation ◽  
Β Amyloid ◽  
Inhibition Studies

Design and Synthesis of 2-Substitutedphenyl Benzo[D]Thiazole Derivatives and Their β-Amyloid Aggregation and Cholinesterase Inhibitory Activities

2019 ◽  
Vol 53 (4) ◽  
pp. 322-328 ◽  
Author(s):  
Merve Zengin ◽  
Oya Unsal-Tan ◽  
Tuba Tüylü Küçükkılınç ◽  
Beyza Ayazgok ◽  
Ayla Balkan
Keyword(s):  
Amyloid Aggregation ◽  
Thiazole Derivatives ◽  
Design And Synthesis ◽  
Β Amyloid ◽  
Inhibitory Activities

Lipophilic ferulic acid derivatives protect PC12 cells against oxidative damage via modulating β-amyloid aggregation and activating Nrf2 enzymes

2020 ◽  
Vol 11 (5) ◽  
pp. 4707-4718 ◽  
Author(s):  
Yu Wu ◽  
Yu-gang Shi ◽  
Xiao-liang Zheng ◽  
Ya-li Dang ◽  
Chen-min Zhu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oxidative Damage ◽  
Ferulic Acid ◽  
Pc12 Cells ◽  
Amyloid Beta ◽  
Neuroprotective Effect ◽  
Amyloid Aggregation ◽  
Β Amyloid

Ferulic acid (FA) has been shown to have a neuroprotective effect on Alzheimer's disease induced by amyloid-beta (Aβ) neurotoxicity.

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