Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles

Pharmacokinetic Profiles ◽

Hiv 1

(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes.

Journal of Virology ◽

10.1128/jvi.70.6.3698-3705.1996 ◽

1996 ◽

Vol 70 (6) ◽

pp. 3698-3705 ◽

Cited By ~ 22

Author(s):

R A Olmsted ◽

D E Slade ◽

L A Kopta ◽

S M Poppe ◽

T J Poel ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Reverse Transcriptase ◽

Human Immunodeficiency Virus Type ◽

Broad Spectrum ◽

Drug Resistant ◽

Immunodeficiency Virus ◽

Hiv 1

Structure of HIV-1 nonnucleoside reverse transcriptase inhibitors derivatives of N-benzyl-benzimidazole with different substituents in position 4

10.1016/j.molstruc.2009.10.034 ◽

2010 ◽

Vol 963 (2-3) ◽

pp. 188-193 ◽

Cited By ~ 3

Author(s):

Natasza E. Ziółkowska ◽

Christopher J. Michejda ◽

Grzegorz D. Bujacz

Keyword(s):

Reverse Transcriptase ◽

Derivatives Of ◽

Hiv 1

Application of 3D-QSAR, Pharmacophore, and Molecular Docking in the Molecular Design of Diarylpyrimidine Derivatives as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors

International Journal of Molecular Sciences ◽

10.3390/ijms19051436 ◽

2018 ◽

Vol 19 (5) ◽

pp. 1436 ◽

Cited By ~ 12

Author(s):

Genyan Liu ◽

Wenjie Wang ◽

Youlan Wan ◽

Xiulian Ju ◽

Shuangxi Gu

Keyword(s):

Molecular Docking ◽

Reverse Transcriptase ◽

Molecular Design ◽

3D Qsar ◽

Hiv 1

Mechanisms of HIV-1 drug resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors

Molecular Biology ◽

10.1134/s0026893311010092 ◽

2011 ◽

Vol 45 (1) ◽

pp. 93-109 ◽

Cited By ~ 7

Author(s):

G. N. Nikolenko ◽

A. T. Kotelkin ◽

S. F. Oreshkova ◽

A. A. Ilyichev

Keyword(s):

Drug Resistance ◽

Reverse Transcriptase ◽

Hiv 1

Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.111874 ◽

2020 ◽

Vol 185 ◽

pp. 111874 ◽

Cited By ~ 3

Author(s):

Sheng Han ◽

Yali Sang ◽

Yan Wu ◽

Yuan Tao ◽

Christophe Pannecouque ◽

...

Keyword(s):

Reverse Transcriptase ◽

Hiv 1

Therapeutic Effects of Nonnucleoside Reverse Transcriptase Inhibitors on the Central Nervous System in HIV-1–Infected Patients

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/00042560-200204010-00006 ◽

2002 ◽

Vol 29 (4) ◽

pp. 363-367

Author(s):

Hans Jürgen von Giesen ◽

Hubertus Köller ◽

Albert Theisen ◽

Gabriele Arendt

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Reverse Transcriptase ◽

Therapeutic Effects ◽

The Central Nervous System ◽

Hiv 1

Crystal structures of HIV-1 nonnucleoside reverse transcriptase inhibitors: N-benzyl-4-methyl-benzimidazoles

10.1016/j.molstruc.2009.05.007 ◽

2009 ◽

Vol 930 (1-3) ◽

pp. 157-161 ◽

Cited By ~ 4

Author(s):

Natasza E. Ziółkowska ◽

Christopher J. Michejda ◽

Grzegorz D. Bujacz

Keyword(s):

Reverse Transcriptase ◽

Crystal Structures ◽

Hiv 1

HIV-1 Reverse Transcriptase Mutants Resistant to Nonnucleoside Reverse Transcriptase Inhibitors Do Not Adversely Affect DNA Synthesis

JAIDS Journal of Acquired Immune Deficiency Syndromes ◽

10.1097/01.qai.0000222288.90201.33 ◽

2006 ◽

Vol 42 (4) ◽

pp. 405-411 ◽

Cited By ~ 5

Author(s):

Robert A. Domaoal ◽

Robert A. Bambara ◽

Lisa M. Demeter

Keyword(s):

Reverse Transcriptase ◽

Dna Synthesis ◽

Hiv 1

Structural studies of series HIV-1 nonnucleoside reverse transcriptase inhibitors 1-(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazoles with different 4-substituents

10.1016/j.molstruc.2009.12.006 ◽

2010 ◽

Vol 966 (1-3) ◽

pp. 53-58

Author(s):

Natasza E. Ziółkowska ◽

Christopher J. Michejda ◽

Grzegorz D. Bujacz

Keyword(s):

Reverse Transcriptase ◽

Structural Studies ◽

Hiv 1

Structural investigation of HIV-1 nonnucleoside reverse transcriptase inhibitors: 2-Aryl-substituted benzimidazoles

10.1016/j.molstruc.2009.08.005 ◽

2009 ◽

Vol 937 (1-3) ◽

pp. 34-38 ◽

Cited By ~ 3

Author(s):

Natasza E. Ziółkowska ◽

Christopher J. Michejda ◽

Grzegorz D. Bujacz

Keyword(s):

Reverse Transcriptase ◽

Structural Investigation ◽

Hiv 1