Self-Healing Metallacycle-Cored Supramolecular Polymers Based on a Metal–Salen Complex Constructed by Orthogonal Metal Coordination and Host–Guest Interaction with Amino Acid Sensing

2021 ◽  
pp. 873-879
Author(s):  
Qian Zhang ◽  
Feng Chen ◽  
Xi Shen ◽  
Tian He ◽  
Huayu Qiu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Metal Coordination ◽  
Supramolecular Polymers ◽  
Self Healing ◽  
Salen Complex ◽  
Amino Acid Sensing ◽  
Metal Salen Complex

Implications of amino acid sensing and dietary protein to the aging process

2019 ◽  
Vol 115 ◽  
pp. 69-78 ◽  
Author(s):  
Oleh Lushchak ◽  
Olha M. Strilbytska ◽  
Ihor Yurkevych ◽  
Alexander M. Vaiserman ◽  
Kenneth B. Storey
Keyword(s):  
Amino Acid ◽  
Dietary Protein ◽  
Aging Process ◽  
Amino Acid Sensing

scholarly journals Activation of the SPS Amino Acid-Sensing Pathway in Saccharomyces cerevisiae Correlates with the Phosphorylation State of a Sensor Component, Ptr3

2007 ◽  
Vol 28 (2) ◽  
pp. 551-563 ◽  
Author(s):  
Zhengchang Liu ◽  
Janet Thornton ◽  
Mário Spírek ◽  
Ronald A. Butow
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Amino Acids ◽  
Amino Acid ◽  
Nuclear Translocation ◽  
Proteolytic Processing ◽  
Casein Kinase I ◽  
Positive Regulators ◽  
Amino Acid Permeases ◽  
Amino Acid Sensing ◽  
Amino Acid Sensor

ABSTRACT Cells of the budding yeast Saccharomyces cerevisiae sense extracellular amino acids and activate expression of amino acid permeases through the SPS-sensing pathway, which consists of Ssy1, an amino acid sensor on the plasma membrane, and two downstream factors, Ptr3 and Ssy5. Upon activation of SPS signaling, two transcription factors, Stp1 and Stp2, undergo Ssy5-dependent proteolytic processing that enables their nuclear translocation. Here we show that Ptr3 is a phosphoprotein whose hyperphosphorylation is increased by external amino acids and is dependent on Ssy1 but not on Ssy5. A deletion mutation in GRR1, encoding a component of the SCFGrr1 E3 ubiquitin ligase, blocks amino acid-induced hyperphosphorylation of Ptr3. We found that two casein kinase I (CKI) proteins, Yck1 and Yck2, previously identified as positive regulators of SPS signaling, are required for hyperphosphorylation of Ptr3. Loss- and gain-of-function mutations in PTR3 result in decreased and increased Ptr3 hyperphosporylation, respectively. We found that a defect in PP2A phosphatase activity leads to the hyperphosphorylation of Ptr3 and constitutive activation of SPS signaling. Two-hybrid analysis revealed interactions between the N-terminal signal transduction domain of Ssy1 with Ptr3 and Yck1. Our findings reveal that CKI and PP2A phosphatase play antagonistic roles in SPS sensing by regulating Ptr3 phosphorylation.

Self-healing metallo-supramolecular polymers from a ligand macromolecule synthesized via copper-catalyzed azide–alkyne cycloaddition and thiol–ene double “click” reactions

2014 ◽  
Vol 5 (6) ◽  
pp. 1945-1953 ◽  
Author(s):  
Bo Yang ◽  
Huan Zhang ◽  
Huiying Peng ◽  
Yuanze Xu ◽  
Bowei Wu ◽  
...  
Keyword(s):  
Supramolecular Polymers ◽  
Self Healing ◽  
Click Reactions

scholarly journals 3D Printing of Solvent-Free Supramolecular Polymers

2021 ◽  
Vol 9 ◽  
Author(s):  
Harald Rupp ◽  
Wolfgang H. Binder
Keyword(s):  
3D Printing ◽  
Dynamic Properties ◽  
Polymeric Materials ◽  
Fundamental Principle ◽  
Supramolecular Polymers ◽  
Fused Deposition Modelling ◽  
Self Healing ◽  
Polymer Science ◽  
Fused Deposition ◽  
Molecular Ordering

Additive manufacturing has significantly changed polymer science and technology by engineering complex material shapes and compositions. With the advent of dynamic properties in polymeric materials as a fundamental principle to achieve, e.g., self-healing properties, the use of supramolecular chemistry as a tool for molecular ordering has become important. By adjusting molecular nanoscopic (supramolecular) bonds in polymers, rheological properties, immanent for 3D printing, can be adjusted, resulting in shape persistence and improved printing. We here review recent progress in the 3D printing of supramolecular polymers, with a focus on fused deposition modelling (FDM) to overcome some of its limitations still being present up to date and open perspectives for their application.

S1609 Amino Acid Sensing Mechanisms in Enteroendocrine STC-1 Cells

2009 ◽  
Vol 136 (5) ◽  
pp. A-234
Author(s):  
Steven H. Young ◽  
Osvaldo Rey ◽  
Enrique Rozengurt
Keyword(s):  
Amino Acid ◽  
Amino Acid Sensing

Two 3D Supramolecular Polymers Constructed from an Amino Acid and a High-Nuclear Ln6Cu24 Cluster Node

2004 ◽  
Vol 10 (16) ◽  
pp. 3963-3969 ◽  
Author(s):  
Jian-Jun Zhang ◽  
Tian-Lu Sheng ◽  
Sheng-Min Hu ◽  
Sheng-Qing Xia ◽  
Guido Leibeling ◽  
...  
Keyword(s):  
Amino Acid ◽  
Supramolecular Polymers
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