Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2

2021 ◽  
Author(s):  
Michael G. Yang ◽  
Zili Xiao ◽  
Rulin Zhao ◽  
Andrew J. Tebben ◽  
Bei Wang ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 2 ◽  
Orally Bioavailable

Novel, Orally Bioavailable γ-Aminoamide CC Chemokine Receptor 2 (CCR2) Antagonists

2006 ◽  
Vol 49 (16) ◽  
pp. 4801-4804 ◽  
Author(s):  
Alexander Pasternak ◽  
Dominick Marino ◽  
Pasquale P. Vicario ◽  
Julia Marie Ayala ◽  
Margaret A. Cascierri ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 2 ◽  
Orally Bioavailable

Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone

2012 ◽  
Vol 22 (9) ◽  
pp. 3311-3316 ◽  
Author(s):  
Percy H. Carter ◽  
Gregory D. Brown ◽  
Sarah R. King ◽  
Matthew E. Voss ◽  
Andrew J. Tebben ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Cc Chemokine Receptor 2 ◽  
Orally Bioavailable

Monocyte chemotactic protein-1 and CC chemokine receptor 2 polymorphisms and prognosis of renal cell carcinoma

Tumor Biology ◽  
2013 ◽  
Vol 34 (5) ◽  
pp. 2741-2746 ◽  
Author(s):  
Guan-Xian Liu ◽  
Xin Zhang ◽  
Su Li ◽  
Richard D. Koiiche ◽  
Jerry H. Sindsceii ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Chemokine Receptor ◽  
Renal Cell ◽  
Cc Chemokine ◽  
Monocyte Chemotactic Protein ◽  
Chemotactic Protein ◽  
Cc Chemokine Receptor 2

Association of Monocyte Chemotactic Protein-1 and CC Chemokine Receptor 2 Gene Variants with Preeclampsia

2010 ◽  
Vol 30 (9) ◽  
pp. 673-676 ◽  
Author(s):  
Bedia Agachan ◽  
Rukset Attar ◽  
Elif Isbilen ◽  
Hulya Yilmaz Aydogan ◽  
Seyma Sozen ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Gene Variants ◽  
Cc Chemokine ◽  
Monocyte Chemotactic Protein ◽  
Chemotactic Protein ◽  
Cc Chemokine Receptor 2

scholarly journals Human Endotoxemia Induces Down-Regulation of Monocyte CC Chemokine Receptor 2

2006 ◽  
Vol 13 (1) ◽  
pp. 156-159 ◽  
Author(s):  
Michael Heesen ◽  
Rosemarijn Renckens ◽  
Alex F. de Vos ◽  
Dagmar Kunz ◽  
Tom van der Poll
Keyword(s):  
Chemokine Receptor ◽  
Peak Plasma ◽  
Plasma Concentrations ◽  
Necrosis Factor Alpha ◽  
Human Endotoxemia ◽  
Cc Chemokine ◽  
Chemotactic Protein ◽  
Human Volunteers ◽  
Cc Chemokine Receptor 2 ◽  
Factor Alpha

ABSTRACT Upon injection of Escherichia coli lipopolysaccharide into human volunteers, the monocyte density of CC chemokine receptor 2 (CCR2) decreased. Minimal CCR2 density was observed 4 h after injection. Peak plasma concentrations of the CCR2 ligand monocyte chemotactic protein 1 and of tumor necrosis factor alpha were reached after 4 h and 2 h, respectively.

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