Gold Nanorods Indirectly Promote Migration of Metastatic Human Breast Cancer Cells in Three-Dimensional Cultures

ACS Nano ◽  
2015 ◽  
Vol 9 (7) ◽  
pp. 6801-6816 ◽  
Author(s):  
Elissa M. Grzincic ◽  
Catherine J. Murphy
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Three Dimensional ◽  
Human Breast Cancer Cells ◽  
Human Breast

Study the Effect of Anticancer Drugs on Human Breast Cancer Cells Using Three Dimensional Silicon Microstructures

2008 ◽  
Author(s):  
Mehdi Nikkhah ◽  
Jeannine S. Strobl ◽  
Masoud Agah
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Trichostatin A ◽  
Three Dimensional ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Adhesion Properties

In this paper we report development of three dimensional silicon microenvironments in order to test the morphological changes and adhesion properties of human breast cancer cells after treatment with different anticancer drugs such as Trichostatin A (TSA), suberoylanilide hydroxamic acid (SAHA) and Scriptaid. Our results indicate that the cancer cells reorganize their cytoskeleton structure after treatment with TSA and Scriptaid. However, SAHA does not change the behavior of the cells inside the three dimensional microstructures while TSA and Scriptaid evoked striking changes in the cells morphology. TSA and Scriptaid drugs cause the cells to stretch inside the isotropic microchambers to avoid contact with curved sidewalls in contrast to their originally rounded shape. The proposed microstructures can be used to evaluate mechanical properties and the pathological grade of various cancer cell lines after different conditions i.e. drug exposure.

Cytotoxic response of platinum-coated gold nanorods in human breast cancer cells at very low exposure levels

2015 ◽  
Vol 31 (11) ◽  
pp. 1344-1356 ◽  
Author(s):  
Maqusood Ahamed ◽  
Mohd Javed Akhtar ◽  
M. A. Majeed Khan ◽  
Hisham A. Alhadlaq ◽  
Salman A. Alrokayan
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Gold Nanorods ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cytotoxic Response ◽  
Exposure Levels ◽  
Low Exposure
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