scholarly journals Picomolar Fingerprinting of Nucleic Acid Nanoparticles Using Solid-State Nanopores

ACS Nano ◽  
2017 ◽  
Vol 11 (10) ◽  
pp. 9701-9710 ◽  
Author(s):  
Mohammad Amin Alibakhshi ◽  
Justin R. Halman ◽  
James Wilson ◽  
Aleksei Aksimentiev ◽  
Kirill A. Afonin ◽  
...  
Keyword(s):  
Solid State ◽  
Nucleic Acid

scholarly journals Direct Detection of Conserved Viral Sequences and Other Nucleic Acid Motifs with Solid-State Nanopores

ACS Nano ◽  
2021 ◽  
Author(s):  
Komal Sethi ◽  
Gabrielle P. Dailey ◽  
Osama K. Zahid ◽  
Ethan W. Taylor ◽  
Jan A. Ruzicka ◽  
...  
Keyword(s):  
Solid State ◽  
Nucleic Acid ◽  
Direct Detection ◽  
Viral Sequences

scholarly journals Exploration of solid-state nanopores in characterizing reaction mixtures generated from a catalytic DNA assembly circuit

2019 ◽  
Vol 10 (7) ◽  
pp. 1953-1961 ◽  
Author(s):  
Zhentong Zhu ◽  
Ruiping Wu ◽  
Bingling Li
Keyword(s):  
Solid State ◽  
Nucleic Acid ◽  
Base Pair ◽  
Quantitative Method ◽  
Dna Assembly ◽  
Characterization Methods ◽  
Catalytic Dna ◽  
Acid Amplifier

We adapt a solid-state nanopore for analyzing DNA assembly mixtures, which is usually a tougher task for either traditional characterization methods or nanopores themselves. A trigger induced nucleic acid amplifier, SP-CHA, is designed as a model. We propose an electrophoresis-gel like, but homogeneous, quantitative method that can comprehensively profile the “base-pair distribution” of SP-CHA concatemer mixtures.

Distinguishing Single- and Double-Stranded Nucleic Acid Molecules Using Solid-State Nanopores

Nano Letters ◽  
2009 ◽  
Vol 9 (8) ◽  
pp. 2953-2960 ◽  
Author(s):  
Gary M. Skinner ◽  
Michiel van den Hout ◽  
Onno Broekmans ◽  
Cees Dekker ◽  
Nynke H. Dekker
Keyword(s):  
Solid State ◽  
Nucleic Acid

ChemInform Abstract: Solid-State NMR Studies of Nucleic Acid Components

ChemInform ◽  
2015 ◽  
Vol 46 (16) ◽  
pp. no-no
Author(s):  
Martin Dracinsk� ◽  
Paul Hodgkinson
Keyword(s):  
Solid State ◽  
Nucleic Acid ◽  
Solid State Nmr ◽  
Nmr Studies

scholarly journals Synthetic heparan sulfate standards and machine learning facilitate the development of solid-state nanopore analysis

2021 ◽  
Vol 118 (11) ◽  
pp. e2022806118
Author(s):  
Ke Xia ◽  
James T. Hagan ◽  
Li Fu ◽  
Brian S. Sheetz ◽  
Somdatta Bhattacharya ◽  
...  
Keyword(s):  
Machine Learning ◽  
Solid State ◽  
Nucleic Acid ◽  
Heparan Sulfate ◽  
Image Recognition ◽  
Single Molecule ◽  
Monosaccharide Composition ◽  
Minimal Representation ◽  
Recognition Algorithms ◽  
Potential Use

The application of solid-state (SS) nanopore devices to single-molecule nucleic acid sequencing has been challenging. Thus, the early successes in applying SS nanopore devices to the more difficult class of biopolymer, glycosaminoglycans (GAGs), have been surprising, motivating us to examine the potential use of an SS nanopore to analyze synthetic heparan sulfate GAG chains of controlled composition and sequence prepared through a promising, recently developed chemoenzymatic route. A minimal representation of the nanopore data, using only signal magnitude and duration, revealed, by eye and image recognition algorithms, clear differences between the signals generated by four synthetic GAGs. By subsequent machine learning, it was possible to determine disaccharide and even monosaccharide composition of these four synthetic GAGs using as few as 500 events, corresponding to a zeptomole of sample. These data suggest that ultrasensitive GAG analysis may be possible using SS nanopore detection and well-characterized molecular training sets.

Carcinogenic alkylation of nucleic acid bases. Structure and conformation of O4-ethyl-2'-deoxythymidine in the solid state and in solution

1986 ◽  
Vol 108 (7) ◽  
pp. 1671-1675 ◽  
Author(s):  
George I. Birnbaum ◽  
Krishan L. Sadana ◽  
Wayne J. P. Blonski ◽  
Frank E. Hruska
Keyword(s):  
Solid State ◽  
Nucleic Acid ◽  
Nucleic Acid Bases
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