Bioengineered Boronic Ester Modified Dextran Polymer Nanoparticles as Reactive Oxygen Species Responsive Nanocarrier for Ischemic Stroke Treatment

ACS Nano ◽  
2018 ◽  
Vol 12 (6) ◽  
pp. 5417-5426 ◽  
Author(s):  
Wei Lv ◽  
Jianpei Xu ◽  
Xiaoqi Wang ◽  
Xinrui Li ◽  
Qunwei Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ischemic Stroke ◽  
Reactive Oxygen ◽  
Polymer Nanoparticles ◽  
Oxygen Species ◽  
Stroke Treatment ◽  
Boronic Ester

scholarly journals Conducting polymer nanoparticles for targeted cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (47) ◽  
pp. 37943-37956 ◽  
Author(s):  
Mona Doshi ◽  
Marissa Krienke ◽  
Saeid Khederzadeh ◽  
Henry Sanchez ◽  
Alicja Copik ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cancer Therapy ◽  
Conducting Polymer ◽  
Targeted Delivery ◽  
Reactive Oxygen ◽  
Polymer Nanoparticles ◽  
Oxygen Species ◽  
Targeted Cancer Therapy ◽  
Fluorescence Bioimaging

Functionalized conducting polymer nanoparticles allow for targeted delivery, tracking by fluorescence bioimaging, and therapeutics through formation of reactive oxygen species.

Neural Stem Cells Transfected with Reactive Oxygen Species-Responsive Polyplexes for Effective Treatment of Ischemic Stroke

2019 ◽  
Vol 31 (10) ◽  
pp. 1807591 ◽  
Author(s):  
Xin-Chi Jiang ◽  
Jia-Jia Xiang ◽  
Hong-Hui Wu ◽  
Tian-Yuan Zhang ◽  
Dan-Ping Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Ischemic Stroke ◽  
Neural Stem Cells ◽  
Effective Treatment ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications

Nanoscale ◽  
2016 ◽  
Vol 8 (13) ◽  
pp. 6958-6963 ◽  
Author(s):  
Eliézer Jäger ◽  
Anita Höcherl ◽  
Olga Janoušková ◽  
Alessandro Jäger ◽  
Martin Hrubý ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Delivery ◽  
Reactive Oxygen ◽  
Polymer Nanoparticles ◽  
Oxygen Species ◽  
Drug Delivery Applications

Reactive oxygen species plasmatic levels in ischemic stroke

2007 ◽  
Vol 303 (1-2) ◽  
pp. 19-25 ◽  
Author(s):  
Laura Nanetti ◽  
Ruja Taffi ◽  
Arianna Vignini ◽  
Cinzia Moroni ◽  
Francesca Raffaelli ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Ischemic Stroke ◽  
Reactive Oxygen ◽  
Oxygen Species

Improvement of a novel proposal for antioxidant treatment against brain damage occurring in ischemic stroke patients.

2020 ◽  
Vol 19 ◽  
Author(s):  
Sofía Orellana-Urzúa ◽  
Gonzalo Claps ◽  
Ramón Rodrigo
Keyword(s):  
Reactive Oxygen Species ◽  
Ischemic Stroke ◽  
Experimental Studies ◽  
Reactive Oxygen ◽  
Cerebral Injury ◽  
Therapeutic Window ◽  
Oxygen Species ◽  
Iron Release ◽  
Stroke Patients

: The underlying mechanism of cerebral injury occurring in patients with acute ischemic stroke involves a key pathophysiological role of oxidative stress. Thus, reactive oxygen species are related to the development of brain edema, calcium overload, mitochondrial dysfunction, excitotoxicity, iron release and inflammation. Nevertheless, although experimental studies have tested the use of antioxidants as an adjuvant therapy in this setting, clinical data and randomized trials are still lacking. Current approved pharmacological therapy is aimed at reperfusion strategies; however, the therapeutic window is limited and also challenged by the injury known to result from the reperfusion. We have recently defined a timecourse occurrence of pathological events triggered by reperfusion-dependent increased reactive oxygen species, thus suggesting the beneficial role of the pertinent use of antioxidants. The present study was aimed to support the hypothesis that an enhanced antioxidant neuroprotection could be achieved by the use of two or more antioxidants opportunely provided to ischemic stroke patients focused against the specific mechanism occurring throughout the pathophysiological process. From this paradigm,using an underexplored therapeutic principle, it could be suggested that antioxidant-based therapy is a novel, promising, safe, available and cost-effective strategy against the deleterious effects of ischemic stroke that needs to be further studied in clinical protocols.

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