scholarly journals Cholesteryl-Conjugated Ribonuclease A Exhibits Enzyme Activity in Aqueous Solution and Resistance to Dimethyl Sulfoxide

ACS Omega ◽  
2021 ◽  
Author(s):  
Shinji Katsura ◽  
Takayuki Furuishi ◽  
Haruhisa Ueda ◽  
Etsuo Yonemochi
Keyword(s):  
Aqueous Solution ◽  
Enzyme Activity ◽  
Dimethyl Sulfoxide ◽  
Ribonuclease A

Self-assembled nano-aggregates of fluorinases demonstrate enhanced enzymatic activity, thermostability and reusability

2020 ◽  
Vol 8 (2) ◽  
pp. 648-656
Author(s):  
Chunhao Tu ◽  
Jin Zhou ◽  
Lei Peng ◽  
Shuli Man ◽  
Long Ma
Keyword(s):  
Aqueous Solution ◽  
Enzyme Activity ◽  
Enzymatic Activity ◽  
Self Assembling ◽  
Self Assembled

Three SAP (self-assembling peptide)-tagged fluorinases (FLAs) are successfully prepared. All three SAP-tagged FLAs bear enzymatic activity and they form nano-sized particles in aqueous solution. One of them displays improved enzyme activity, thermostability and reusability.

Effect of Different Salt Concentrations on Dimethyl Sulfoxide (DMSO) Nanocluster Structures by Molecular Dynamics Simulations

2020 ◽  
Vol 20 (8) ◽  
pp. 4799-4806
Author(s):  
Peng Xie ◽  
Shubin Jin ◽  
Chenggang Sun ◽  
Yushu Xie
Keyword(s):  
Aqueous Solution ◽  
Dimethyl Sulfoxide ◽  
Water Cluster ◽  
Water Solution ◽  
Md Simulations ◽  
Water Molecules ◽  
Nacl Concentration ◽  
Dynamics Simulations ◽  
Simulation Systems ◽  
Decentralized Model

We performed MD simulations to examine dimethyl sulfoxide (DMSO) nanocluster structures in NaCl aqueous solution with different concentrations (0.45 g/100 mL, 0.9 g/100 mL, 1.8 g/100 mL, 2.7 g/100 mL, and 3.6 g/100 mL). Results showed that interaction between Na+ and DMSO at the first solvation shells was weakened due to acceleration rotational influence of ion driven by NaCl concentration. We investigated the tetrahedral order parameter and average H-B number of water molecules. These results indicated that NaCl influenced the solvation structure of water cluster, but that of DMSO was not affected by NaCl. We also found that Na+ was prior solvated by water solution in these mixture systems, and Cl− only existed in the water cluster in our simulation systems. Consequently, we herein proposed a decentralized model that depicts microphysical structure images of DMSO in NaCl aqueous solution systems.

Proton NMR assignments and regular backbone structure of bovine pancreatic ribonuclease A in aqueous solution

Biochemistry ◽  
1989 ◽  
Vol 28 (14) ◽  
pp. 5930-5938 ◽  
Author(s):  
Andrew D. Robertson ◽  
Enrico O. Purisima ◽  
Margaret A. Eastman ◽  
Harold A. Scheraga
Keyword(s):  
Aqueous Solution ◽  
Nmr Assignments ◽  
Proton Nmr ◽  
Ribonuclease A ◽  
Pancreatic Ribonuclease ◽  
Backbone Structure ◽  
Pancreatic Ribonuclease A
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