scholarly journals Diketopiperazines as Cross-Communication Quorum-Sensing Signals between Cronobacter sakazakii and Bacillus cereus

ACS Omega ◽  
2017 ◽  
Vol 2 (3) ◽  
pp. 1003-1008 ◽  
Author(s):  
Matheus R. Bofinger ◽  
Lucas S. de Sousa ◽  
José E. N. Fontes ◽  
Anita J. Marsaioli
Keyword(s):  
Quorum Sensing ◽  
Bacillus Cereus ◽  
Cronobacter Sakazakii ◽  
Quorum Sensing Signals

The architecture of a mixed fungal–bacterial biofilm is modulated by quorum‐sensing signals

2021 ◽  
Author(s):  
Alberto Ruiz ◽  
Marta Herráez ◽  
Stefanie B. Costa‐Gutierrez ◽  
María Antonia Molina‐Henares ◽  
María Jesús Martínez ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Bacterial Biofilm ◽  
Quorum Sensing Signals

scholarly journals Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets

2014 ◽  
Vol 19 (5) ◽  
pp. 405-418 ◽  
Author(s):  
Tomohiro Shimada ◽  
Kaori Shimada ◽  
Makoto Matsui ◽  
Yuichi Kitai ◽  
Jun Igarashi ◽  
...  
Keyword(s):  
Cell Division ◽  
Quorum Sensing ◽  
Transcription Regulation ◽  
Control Factor ◽  
Quorum Sensing Signals ◽  
Cell Division Control

scholarly journals Bacillus cereus Induces Permeability of an In Vitro Blood-Retina Barrier

2008 ◽  
Vol 76 (4) ◽  
pp. 1358-1367 ◽  
Author(s):  
A. L. Moyer ◽  
R. T. Ramadan ◽  
J. Thurman ◽  
A. Burroughs ◽  
M. C. Callegan
Keyword(s):  
Quorum Sensing ◽  
Bacillus Cereus ◽  
Barrier Function ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Toxin Production ◽  
Global Regulator ◽  
Barrier Permeability ◽  
Cell Monolayers

ABSTRACT Most Bacillus cereus toxin production is controlled by the quorum-sensing-dependent, pleiotropic global regulator plcR, which contributes to the organism's virulence in the eye. The purpose of this study was to analyze the effects of B. cereus infection and plcR-regulated toxins on the barrier function of retinal pigment epithelium (RPE) cells, the primary cells of the blood-retina barrier. Human ARPE-19 cells were apically inoculated with wild-type or quorum-sensing-deficient B. cereus, and cytotoxicity was analyzed. plcR-regulated toxins were not required for B. cereus-induced RPE cytotoxicity, but these toxins did increase the rate of cell death, primarily by necrosis. B. cereus infection of polarized RPE cell monolayers resulted in increased barrier permeability, independent of plcR-regulated toxins. Loss of both occludin and ZO-1 expression occurred by 8 h postinfection, but alterations in tight junctions appeared to precede cytotoxicity. Of the several proinflammatory cytokines analyzed, only interleukin-6 was produced in response to B. cereus infection. These results demonstrate the deleterious effects of B. cereus infection on RPE barrier function and suggest that plcR-regulated toxins may not contribute significantly to RPE barrier permeability during infection.

scholarly journals Host modification of a bacterial quorum-sensing signal induces a phenotypic switch in bacterial symbionts

2017 ◽  
Vol 114 (40) ◽  
pp. E8488-E8497 ◽  
Author(s):  
Cleo Pietschke ◽  
Christian Treitz ◽  
Sylvain Forêt ◽  
Annika Schultze ◽  
Sven Künzel ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Bacterial Communities ◽  
Homoserine Lactone ◽  
Innate Immune ◽  
Expression Data ◽  
Phenotypic Switch ◽  
Host Colonization ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Quorum Sensing Signals

Bacterial communities colonize epithelial surfaces of most animals. Several factors, including the innate immune system, mucus composition, and diet, have been identified as determinants of host-associated bacterial communities. Here we show that the early branching metazoan Hydra is able to modify bacterial quorum-sensing signals. We identified a eukaryotic mechanism that enables Hydra to specifically modify long-chain 3-oxo-homoserine lactones into their 3-hydroxy-HSL counterparts. Expression data revealed that Hydra’s main bacterial colonizer, Curvibacter sp., responds differentially to N-(3-hydroxydodecanoyl)-l-homoserine lactone (3OHC12-HSL) and N-(3-oxododecanoyl)-l-homoserine lactone (3OC12-HSL). Investigating the impacts of the different N-acyl-HSLs on host colonization elucidated that 3OHC12-HSL allows and 3OC12-HSL represses host colonization of Curvibacter sp. These results show that an animal manipulates bacterial quorum-sensing signals and that this modification leads to a phenotypic switch in the bacterial colonizers. This mechanism may enable the host to manipulate the gene expression and thereby the behavior of its bacterial colonizers.

The Role of Regulators in the Expression of Quorum-Sensing Signals in Pseudomonas aeruginosa

2003 ◽  
Vol 6 (2) ◽  
pp. 88-100 ◽  
Author(s):  
Magnus G. Fagerlind ◽  
Scott A. Rice ◽  
Patric Nilsson ◽  
Mikael Harlén ◽  
Sally James ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Quorum Sensing ◽  
Quorum Sensing Signals
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